Low HLA-DR expression on monocytes as a prognostic marker for bacterial sepsis after liver transplantation

VandenBerk, JMM., Oldenbruger, RHJ., VandenBerg, AP., Klompmaker, IJ., Mesander, G., VanSon, WJ., VanderBij, W., Slooff, MJH. & The, TH., 27-Jun-1997, In : Transplantation. 63, 12, p. 1846-1848 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

Background. Low HLA-DR expression on monocytes is associated with an increased risk of infection after surgery or trauma. We determined the value of this parameter as a marker for sepsis after liver transplantation.

Methods. The percentage of monocytes expressing HLA-DR was determined by flow cytometry before and after liver transplantation in nine patients. Five lung and 20 kidney transplant recipients served as controls.

Results. Bacterial sepsis occurred in 5 of 9 liver transplant patients and 0 of 24 control patients. Monocyte HLA-DR expression decreased 50% in the four liver transplant patients without sepsis. Only 1 of 25 control patients had persistently low monocyte HLA-DR expression.

Conclusions. Monitoring of monocyte HLA-DR expression may be helpful in identifying liver transplant patients who have an increased risk of imminent bacterial sepsis.

Original languageEnglish
Pages (from-to)1846-1848
Number of pages3
Issue number12
Publication statusPublished - 27-Jun-1997

ID: 6517579