Publication

Losartan in patients with renal insufficiency

De Zeeuw, D., Gansevoort, R. T. & De Jong, P. E., Aug-1995, In : Canadian Journal of Cardiology. 11, p. F41-F44 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

A choice of many antihypertensive strategies is not offered for the treatment of the hypertensive patient with renal insufficiency. Angiotensin-converting enzyme (ACE) inhibitors appear to be the drugs of choice since they not only lower blood pressure but also reduce some important risk factors that may cause progressive loss of renal function, such as intraglomerular hypertension, angiotensin II (ANG II)-induced glomerular growth, proteinuria and hypertension, angiotensin II (ANG II)-induced glomerular growth, proteinuria and hyperlipidemia. Indeed, several clinical studies now show that ACE inhibitors offer renal protection beyond the lowering of systemic blood pressure. The new class of Ang II receptor antagonists and its first representative losartan has not yet been tested antagonists and its first representative losartan has not yet been tested clinically for its renal protective efficacy. The first signs, however, look promising, since losartan appears to induce changes in several identified risk factors to the same extent as ACE inhibitors, such as renal vasodilation, and a fall in proteinuria and serum lipids. The challenge will be to discover the differences between ACE inhibitors and Ang II receptor antagonists and to use them to the future advantage of the renal patient.

Original languageEnglish
Pages (from-to)F41-F44
Number of pages4
JournalCanadian Journal of Cardiology
Volume11
Publication statusPublished - Aug-1995
EventSatellite Symposium on Angiotensin II Receptors - A New Target for Clinical Intervention in Hypertension, of the Annual Meeting of the Societe-Quebecoise-d-Hypertension-Arterielle - , Canada
Duration: 14-Jan-1995 → …

Event

Satellite Symposium on Angiotensin II Receptors - A New Target for Clinical Intervention in Hypertension, of the Annual Meeting of the Societe-Quebecoise-d-Hypertension-Arterielle

14/01/1995 → …

Canada

Event: Other

    Keywords

  • ANGIOTENSIN II, ANGIOTENSIN II RECEPTOR ANTAGONISM, ANGIOTENSIN-CONVERTING ENZYME INHIBITION, KIDNEY, PROTEINURIA, RENAL FUNCTION

ID: 6436560