Long-Term Outcome after Joint Bleeds in Von Willebrand Disease Compared to Haemophilia A: A Post Hoc AnalysisWiN Studygrp, Oct-2018, In : Thrombosis and Haemostasis. 118, 10, p. 1690-1700 11 p.
Research output: Contribution to journal › Article › Academic › peer-review
Long-term outcome after joint bleeds in vonWillebrand disease (VWD) (vonWillebrand factor activity 5/joint) less often thanmoderate and severe HA patients (52% vs. 77% vs. 98%). HJHS and PS in VWD were similar to moderate HA (median HJHS 5 vs. 6, RR 0.9 [0.5-1.4] and PS > 3 of >= 1 joint OR 0.3 [0.1-1.4]), but better than in severe HA patients (median HJHS 5 vs. 9, RR 1.8 [1.1-2.9]; PS > 3 in any joint OR 0.1 [0.0-0.3]). Self-reported limitations in activities were comparable across VWD, moderate HA (HAL score <95: 67% vs. 49%; OR 1.4 [0.53.6]) and young adults with severe HA (67% vs. 48%; OR 1.7 [0.7-4.4]). Despite fewer joint bleeds, joint outcome after joint bleeds was similar in VWD and moderate HA patients. Type 3 VWD patients had worst joint outcome, comparable to younger intensively treated severe HA patients. Limitations in activities occurred as often in VWD as in both moderate and severe HA.
|Number of pages||11|
|Journal||Thrombosis and Haemostasis|
|Publication status||Published - Oct-2018|
- von Willebrand disease, joint bleed, arthropathy, haemophilia A, HJHS, Pettersson, HAL, QUALITY-OF-LIFE, ACTIVITIES LIST, HEALTH SCORE, PROPHYLAXIS NETWORK, MODERATE HEMOPHILIA, ADULT PATIENTS, ARTHROPATHY, RELIABILITY, MANAGEMENT, ASSOCIATION