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Long-Term beta-galacto-oligosaccharides Supplementation Decreases the Development of Obesity and Insulin Resistance in Mice Fed a Western-Type Diet

Mistry, R. H., Liu, F., Borewicz, K., Lohuis, M. A. M., Smidt, H., Verkade, H. J. & Tietge, U. J. F., 25-May-2020, In : Molecular Nutrition & Food Research. 11 p., 1900922.

Research output: Contribution to journalArticleAcademicpeer-review

Scope The gut microbiota might critically modify metabolic disease development. Dietary fibers such as galacto-oligosaccharides (GOS) presumably stimulate bacteria beneficial for metabolic health. This study assesses the impact of GOS on obesity, glucose, and lipid metabolism.

Methods and results Following Western-type diet feeding (C57BL/6 mice) with or without beta-GOS (7% w/w, 15 weeks), body composition, glucose and insulin tolerance, lipid profiles, fat kinetics and microbiota composition are analyzed. GOS reduces body weight gain (p <0.01), accumulation of epididymal (p <0.05), perirenal (p <0.01) fat, and insulin resistance (p <0.01). GOS-fed mice have lower plasma cholesterol (p <0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p <0.01), more fecal neutral sterol excretion (p <0.05) and higher intestinal GLP-1 expression (p <0.01). Fecal bile acid excretion is lower (p <0.01) in GOS-fed mice with significant compositional differences, namely decreased cholic, alpha-muricholic, and deoxycholic acid excretion, whereas hyodeoxycholic acid increased. Substantial changes in microbiota composition, conceivably beneficial for metabolic health, occurred upon GOS feeding.

Conclusion GOS supplementation to a Western-type diet improves body weight gain, dyslipidemia, and insulin sensitivity, supporting a therapeutic potential of GOS for individuals at risk of developing metabolic syndrome.

Original languageEnglish
Article number1900922
Number of pages11
JournalMolecular Nutrition & Food Research
Early online date2020
Publication statusPublished - 25-May-2020

    Keywords

  • adipose tissue, galactooligosaccharides, lipid absorption, microbiota, prebiotics, GLUCAGON-LIKE PEPTIDE-1, CHAIN FATTY-ACIDS, GUT MICROBIOTA, FECAL MICROBIOTA, IMMUNE FUNCTION, CHOLESTEROL, BIFIDOBACTERIA, METABOLISM, SECRETION, INCREASES

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