Publication

Long-term Air Pollution Exposure, Genome-wide DNA Methylation and Lung Function in the LifeLines Cohort Study

de F C Lichtenfels, A. J., van der Plaat, D. A., de Jong, K., van Diemen, C. C., Postma, D. S., Nedeljkovic, I., van Duijn, C. M., Amin, N., la Bastide-van Gemert, S., de Vries, M., Ward-Caviness, C. K., Wolf, K., Waldenberger, M., Peters, A., Stolk, R. P., Brunekreef, B., Boezen, H. M. & Vonk, J. M., 6-Feb-2018, In : Environmental Health Perspectives. 126, 2, 8 p., 027004.

Research output: Contribution to journalArticleAcademicpeer-review

APA

de F C Lichtenfels, A. J., van der Plaat, D. A., de Jong, K., van Diemen, C. C., Postma, D. S., Nedeljkovic, I., ... Vonk, J. M. (2018). Long-term Air Pollution Exposure, Genome-wide DNA Methylation and Lung Function in the LifeLines Cohort Study. Environmental Health Perspectives, 126(2), [027004]. https://doi.org/10.1289/EHP2045

Author

de F C Lichtenfels, Ana Julia ; van der Plaat, Diana A ; de Jong, Kim ; van Diemen, Cleo C ; Postma, Dirkje S ; Nedeljkovic, Ivana ; van Duijn, Cornelia M ; Amin, Najaf ; la Bastide-van Gemert, Sacha ; de Vries, Maaike ; Ward-Caviness, Cavin K ; Wolf, Kathrin ; Waldenberger, Melanie ; Peters, Annette ; Stolk, Ronald P ; Brunekreef, Bert ; Boezen, H Marike ; Vonk, Judith M. / Long-term Air Pollution Exposure, Genome-wide DNA Methylation and Lung Function in the LifeLines Cohort Study. In: Environmental Health Perspectives. 2018 ; Vol. 126, No. 2.

Harvard

de F C Lichtenfels, AJ, van der Plaat, DA, de Jong, K, van Diemen, CC, Postma, DS, Nedeljkovic, I, van Duijn, CM, Amin, N, la Bastide-van Gemert, S, de Vries, M, Ward-Caviness, CK, Wolf, K, Waldenberger, M, Peters, A, Stolk, RP, Brunekreef, B, Boezen, HM & Vonk, JM 2018, 'Long-term Air Pollution Exposure, Genome-wide DNA Methylation and Lung Function in the LifeLines Cohort Study' Environmental Health Perspectives, vol. 126, no. 2, 027004. https://doi.org/10.1289/EHP2045

Standard

Long-term Air Pollution Exposure, Genome-wide DNA Methylation and Lung Function in the LifeLines Cohort Study. / de F C Lichtenfels, Ana Julia; van der Plaat, Diana A; de Jong, Kim; van Diemen, Cleo C; Postma, Dirkje S; Nedeljkovic, Ivana; van Duijn, Cornelia M; Amin, Najaf; la Bastide-van Gemert, Sacha; de Vries, Maaike; Ward-Caviness, Cavin K; Wolf, Kathrin; Waldenberger, Melanie; Peters, Annette; Stolk, Ronald P; Brunekreef, Bert; Boezen, H Marike; Vonk, Judith M.

In: Environmental Health Perspectives, Vol. 126, No. 2, 027004, 06.02.2018.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

de F C Lichtenfels AJ, van der Plaat DA, de Jong K, van Diemen CC, Postma DS, Nedeljkovic I et al. Long-term Air Pollution Exposure, Genome-wide DNA Methylation and Lung Function in the LifeLines Cohort Study. Environmental Health Perspectives. 2018 Feb 6;126(2). 027004. https://doi.org/10.1289/EHP2045


BibTeX

@article{dfc18376666147ed8a6f88efeb39cfba,
title = "Long-term Air Pollution Exposure, Genome-wide DNA Methylation and Lung Function in the LifeLines Cohort Study",
abstract = "BACKGROUND: Long-term air pollution exposure is negatively associated with lung function, yet the mechanisms underlying this association not fully clear. Differential DNA methylation may explain this association.OBJECTIVES: Our main aim was to study the association between long-term air pollution exposure and DNA methylation.METHODS: We performed a genome-wide methylation study using robust linear regression models in 1,017 subjects from the LifeLines cohort study to analyze the association between exposure to nitrogen dioxide (NO2) and particulate matter (PM2.5, fine particulate matter with aerodynamic diameterRESULTS: Depending on the p-value threshold used, we found significant associations between NO2 exposure and DNA methylation for seven CpG sites (Bonferroni corrected threshold p <1.19 x 10(-7)) or for 4,980 CpG sites (False Discovery RateCONCLUSIONS: Long-term NO2 exposure was genome-wide significantly associated with DNA methylation in the identification cohort but not in the replication cohort. Future studies arc needed to further elucidate the potential mechanisms underlying NO2-exposure related respiratory disease.",
keywords = "OBSTRUCTIVE PULMONARY-DISEASE, ARTERY ENDOTHELIAL-CELLS, FINE PARTICULATE MATTER, USE REGRESSION-MODELS, ESCAPE PROJECT, EPIGENETIC MEDIATION, NITROGEN-DIOXIDE, PHOSPHOLIPASE-D, BLOOD-PRESSURE, ASSOCIATIONS",
author = "{de F C Lichtenfels}, {Ana Julia} and {van der Plaat}, {Diana A} and {de Jong}, Kim and {van Diemen}, {Cleo C} and Postma, {Dirkje S} and Ivana Nedeljkovic and {van Duijn}, {Cornelia M} and Najaf Amin and {la Bastide-van Gemert}, Sacha and {de Vries}, Maaike and Ward-Caviness, {Cavin K} and Kathrin Wolf and Melanie Waldenberger and Annette Peters and Stolk, {Ronald P} and Bert Brunekreef and Boezen, {H Marike} and Vonk, {Judith M}",
year = "2018",
month = "2",
day = "6",
doi = "10.1289/EHP2045",
language = "English",
volume = "126",
journal = "Environmental Health Perspectives",
issn = "0091-6765",
publisher = "US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE",
number = "2",

}

RIS

TY - JOUR

T1 - Long-term Air Pollution Exposure, Genome-wide DNA Methylation and Lung Function in the LifeLines Cohort Study

AU - de F C Lichtenfels, Ana Julia

AU - van der Plaat, Diana A

AU - de Jong, Kim

AU - van Diemen, Cleo C

AU - Postma, Dirkje S

AU - Nedeljkovic, Ivana

AU - van Duijn, Cornelia M

AU - Amin, Najaf

AU - la Bastide-van Gemert, Sacha

AU - de Vries, Maaike

AU - Ward-Caviness, Cavin K

AU - Wolf, Kathrin

AU - Waldenberger, Melanie

AU - Peters, Annette

AU - Stolk, Ronald P

AU - Brunekreef, Bert

AU - Boezen, H Marike

AU - Vonk, Judith M

PY - 2018/2/6

Y1 - 2018/2/6

N2 - BACKGROUND: Long-term air pollution exposure is negatively associated with lung function, yet the mechanisms underlying this association not fully clear. Differential DNA methylation may explain this association.OBJECTIVES: Our main aim was to study the association between long-term air pollution exposure and DNA methylation.METHODS: We performed a genome-wide methylation study using robust linear regression models in 1,017 subjects from the LifeLines cohort study to analyze the association between exposure to nitrogen dioxide (NO2) and particulate matter (PM2.5, fine particulate matter with aerodynamic diameterRESULTS: Depending on the p-value threshold used, we found significant associations between NO2 exposure and DNA methylation for seven CpG sites (Bonferroni corrected threshold p <1.19 x 10(-7)) or for 4,980 CpG sites (False Discovery RateCONCLUSIONS: Long-term NO2 exposure was genome-wide significantly associated with DNA methylation in the identification cohort but not in the replication cohort. Future studies arc needed to further elucidate the potential mechanisms underlying NO2-exposure related respiratory disease.

AB - BACKGROUND: Long-term air pollution exposure is negatively associated with lung function, yet the mechanisms underlying this association not fully clear. Differential DNA methylation may explain this association.OBJECTIVES: Our main aim was to study the association between long-term air pollution exposure and DNA methylation.METHODS: We performed a genome-wide methylation study using robust linear regression models in 1,017 subjects from the LifeLines cohort study to analyze the association between exposure to nitrogen dioxide (NO2) and particulate matter (PM2.5, fine particulate matter with aerodynamic diameterRESULTS: Depending on the p-value threshold used, we found significant associations between NO2 exposure and DNA methylation for seven CpG sites (Bonferroni corrected threshold p <1.19 x 10(-7)) or for 4,980 CpG sites (False Discovery RateCONCLUSIONS: Long-term NO2 exposure was genome-wide significantly associated with DNA methylation in the identification cohort but not in the replication cohort. Future studies arc needed to further elucidate the potential mechanisms underlying NO2-exposure related respiratory disease.

KW - OBSTRUCTIVE PULMONARY-DISEASE

KW - ARTERY ENDOTHELIAL-CELLS

KW - FINE PARTICULATE MATTER

KW - USE REGRESSION-MODELS

KW - ESCAPE PROJECT

KW - EPIGENETIC MEDIATION

KW - NITROGEN-DIOXIDE

KW - PHOSPHOLIPASE-D

KW - BLOOD-PRESSURE

KW - ASSOCIATIONS

U2 - 10.1289/EHP2045

DO - 10.1289/EHP2045

M3 - Article

VL - 126

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

SN - 0091-6765

IS - 2

M1 - 027004

ER -

ID: 54108299