Long-term Air Pollution Exposure, Genome-wide DNA Methylation and Lung Function in the LifeLines Cohort Studyde F C Lichtenfels, A. J., van der Plaat, D. A., de Jong, K., van Diemen, C. C., Postma, D. S., Nedeljkovic, I., van Duijn, C. M., Amin, N., la Bastide-van Gemert, S., de Vries, M., Ward-Caviness, C. K., Wolf, K., Waldenberger, M., Peters, A., Stolk, R. P., Brunekreef, B., Boezen, H. M. & Vonk, J. M., 6-Feb-2018, In : Environmental Health Perspectives. 126, 2, 8 p., 027004.
Research output: Contribution to journal › Article › Academic › peer-review
BACKGROUND: Long-term air pollution exposure is negatively associated with lung function, yet the mechanisms underlying this association not fully clear. Differential DNA methylation may explain this association.
OBJECTIVES: Our main aim was to study the association between long-term air pollution exposure and DNA methylation.
METHODS: We performed a genome-wide methylation study using robust linear regression models in 1,017 subjects from the LifeLines cohort study to analyze the association between exposure to nitrogen dioxide (NO2) and particulate matter (PM2.5, fine particulate matter with aerodynamic diameter
RESULTS: Depending on the p-value threshold used, we found significant associations between NO2 exposure and DNA methylation for seven CpG sites (Bonferroni corrected threshold p <1.19 x 10(-7)) or for 4,980 CpG sites (False Discovery Rate
CONCLUSIONS: Long-term NO2 exposure was genome-wide significantly associated with DNA methylation in the identification cohort but not in the replication cohort. Future studies arc needed to further elucidate the potential mechanisms underlying NO2-exposure related respiratory disease.
|Number of pages||8|
|Journal||Environmental Health Perspectives|
|Publication status||Published - 6-Feb-2018|
- OBSTRUCTIVE PULMONARY-DISEASE, ARTERY ENDOTHELIAL-CELLS, FINE PARTICULATE MATTER, USE REGRESSION-MODELS, ESCAPE PROJECT, EPIGENETIC MEDIATION, NITROGEN-DIOXIDE, PHOSPHOLIPASE-D, BLOOD-PRESSURE, ASSOCIATIONS
Bakker, S. (Creator), Dotinga, A. (Creator), Vonk, J. (Creator), Smidt, N. (Creator), Scholtens, S. (Creator), Swertz, M. (Creator), Wijmenga, C. (Creator), Wolffenbuttel, B. (Creator), Stolk, R. (Creator), Zon, van, S. (Creator), Rosmalen, J. (Creator), Postma, D. S. (Creator), Boer, de, R. (Creator), Navis, G. (Creator), Slaets, J. (Creator), Ormel, J. (Creator), Dijk, van, F. (Creator), Lifelines, 2006