Publication

Long telomeres are preferentially extended during recombination-mediated telomere maintenance

Chang, M., Dittmar, J. C. & Rothstein, R., Apr-2011, In : Nature Structural & Molecular Biology. 18, 4, p. 451-456 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Chang, M., Dittmar, J. C., & Rothstein, R. (2011). Long telomeres are preferentially extended during recombination-mediated telomere maintenance. Nature Structural & Molecular Biology, 18(4), 451-456. https://doi.org/10.1038/nsmb.2034

Author

Chang, Michael ; Dittmar, John C. ; Rothstein, Rodney. / Long telomeres are preferentially extended during recombination-mediated telomere maintenance. In: Nature Structural & Molecular Biology. 2011 ; Vol. 18, No. 4. pp. 451-456.

Harvard

Chang, M, Dittmar, JC & Rothstein, R 2011, 'Long telomeres are preferentially extended during recombination-mediated telomere maintenance' Nature Structural & Molecular Biology, vol. 18, no. 4, pp. 451-456. https://doi.org/10.1038/nsmb.2034

Standard

Long telomeres are preferentially extended during recombination-mediated telomere maintenance. / Chang, Michael; Dittmar, John C.; Rothstein, Rodney.

In: Nature Structural & Molecular Biology, Vol. 18, No. 4, 04.2011, p. 451-456.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Chang M, Dittmar JC, Rothstein R. Long telomeres are preferentially extended during recombination-mediated telomere maintenance. Nature Structural & Molecular Biology. 2011 Apr;18(4):451-456. https://doi.org/10.1038/nsmb.2034


BibTeX

@article{cd3cfa003842452f8a6b1d1877052718,
title = "Long telomeres are preferentially extended during recombination-mediated telomere maintenance",
abstract = "Most human somatic cells do not express telomerase. Consequently, with each cell division their telomeres progressively shorten until replicative senescence is induced. Around 15{\%} of human cancers maintain their telomeres using telomerase-independent, recombination-based mechanisms that are collectively termed 'alternative lengthening of telomeres' (ALT). In the yeast Saccharomyces cerevisiae, ALT cells are referred to as 'survivors'. One type of survivor (type II) resembles human ALT cells in that both are defined by the amplification of telomeric repeats. We analyzed recombination-mediated telomere extension events at individual telomeres in telomerase-negative yeast during the formation of type II survivors and found that long telomeres were preferentially extended. Furthermore, senescent cells with long telomeres were more efficient at bypassing senescence by the type II pathway. We speculate that telomere length may be important in determining whether cancer cells use telomerase or ALT to bypass replicative senescence.",
keywords = "SACCHAROMYCES-CEREVISIAE TELOMERES, BREAK-INDUCED REPLICATION, HOMOLOGOUS RECOMBINATION, ESCHERICHIA-COLI, SUBSTRATE LENGTH, MAMMALIAN-CELLS, YEAST TELOMERES, ABSENCE, ELONGATION, SENESCENCE",
author = "Michael Chang and Dittmar, {John C.} and Rodney Rothstein",
year = "2011",
month = "4",
doi = "10.1038/nsmb.2034",
language = "English",
volume = "18",
pages = "451--456",
journal = "Nature Structural & Molecular Biology",
issn = "1545-9985",
publisher = "Nature Publishing Group",
number = "4",

}

RIS

TY - JOUR

T1 - Long telomeres are preferentially extended during recombination-mediated telomere maintenance

AU - Chang, Michael

AU - Dittmar, John C.

AU - Rothstein, Rodney

PY - 2011/4

Y1 - 2011/4

N2 - Most human somatic cells do not express telomerase. Consequently, with each cell division their telomeres progressively shorten until replicative senescence is induced. Around 15% of human cancers maintain their telomeres using telomerase-independent, recombination-based mechanisms that are collectively termed 'alternative lengthening of telomeres' (ALT). In the yeast Saccharomyces cerevisiae, ALT cells are referred to as 'survivors'. One type of survivor (type II) resembles human ALT cells in that both are defined by the amplification of telomeric repeats. We analyzed recombination-mediated telomere extension events at individual telomeres in telomerase-negative yeast during the formation of type II survivors and found that long telomeres were preferentially extended. Furthermore, senescent cells with long telomeres were more efficient at bypassing senescence by the type II pathway. We speculate that telomere length may be important in determining whether cancer cells use telomerase or ALT to bypass replicative senescence.

AB - Most human somatic cells do not express telomerase. Consequently, with each cell division their telomeres progressively shorten until replicative senescence is induced. Around 15% of human cancers maintain their telomeres using telomerase-independent, recombination-based mechanisms that are collectively termed 'alternative lengthening of telomeres' (ALT). In the yeast Saccharomyces cerevisiae, ALT cells are referred to as 'survivors'. One type of survivor (type II) resembles human ALT cells in that both are defined by the amplification of telomeric repeats. We analyzed recombination-mediated telomere extension events at individual telomeres in telomerase-negative yeast during the formation of type II survivors and found that long telomeres were preferentially extended. Furthermore, senescent cells with long telomeres were more efficient at bypassing senescence by the type II pathway. We speculate that telomere length may be important in determining whether cancer cells use telomerase or ALT to bypass replicative senescence.

KW - SACCHAROMYCES-CEREVISIAE TELOMERES

KW - BREAK-INDUCED REPLICATION

KW - HOMOLOGOUS RECOMBINATION

KW - ESCHERICHIA-COLI

KW - SUBSTRATE LENGTH

KW - MAMMALIAN-CELLS

KW - YEAST TELOMERES

KW - ABSENCE

KW - ELONGATION

KW - SENESCENCE

U2 - 10.1038/nsmb.2034

DO - 10.1038/nsmb.2034

M3 - Article

VL - 18

SP - 451

EP - 456

JO - Nature Structural & Molecular Biology

JF - Nature Structural & Molecular Biology

SN - 1545-9985

IS - 4

ER -

ID: 14316733