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Long telomeres: Too much of a good thing

Chang, M., 2012, In : BioMolecular Concepts. 3, p. 387-393 7 p.

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DOI

Telomeres, the physical ends of linear eukaryotic chromosomes, protect chromosome ends from end fusions and degradation. Telomere length is tightly regulated to ensure that telomeres are neither too short nor too long. Short telomeres are preferentially elongated by the enzyme telomerase. In the absence of telomerase, telomeres progressively shorten with each round of cell division. Critically shortened telomeres lose their ability to protect chromosome ends, inducing cell cycle arrest and senescence. While the consequences and cellular response to short telomeres are frequently explored, long telomeres also pose problems and cells have evolved mechanisms to shorten over-elongated telomeres. These aspects of long telomeres are discussed in this short concep- tual overview.
Original languageEnglish
Pages (from-to)387-393
Number of pages7
JournalBioMolecular Concepts
Volume3
Publication statusPublished - 2012

    Keywords

  • telomerase, telomere length regulation, telomere rapid deletion, telomeres

ID: 14317391