Publication

Long Noncoding RNA Expression Profiling in Normal B-Cell Subsets and Hodgkin Lymphoma Reveals Hodgkin and Reed-Sternberg Cell Specific Long Noncoding RNAs

Tayari, M. M., Winkle, M., Kortman, G., Sietzema, J., de Jong, D., Terpstra, M., Mestdagh, P., Kroese, F. G. M., Visser, L., Diepstra, A., Kok, K., van den Berg, A. & Kluiver, J., Sep-2016, In : The American Journal of Pathology. 186, 9, p. 2462-2472 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Tayari, M. M., Winkle, M., Kortman, G., Sietzema, J., de Jong, D., Terpstra, M., ... Kluiver, J. (2016). Long Noncoding RNA Expression Profiling in Normal B-Cell Subsets and Hodgkin Lymphoma Reveals Hodgkin and Reed-Sternberg Cell Specific Long Noncoding RNAs. The American Journal of Pathology, 186(9), 2462-2472. https://doi.org/10.1016/j.ajpath.2016.05.011

Author

Tayari, Mina Masoumeh ; Winkle, Melanie ; Kortman, Gertrud ; Sietzema, Jantine ; de Jong, Debora ; Terpstra, Martijn ; Mestdagh, Pieter ; Kroese, Frans G. M. ; Visser, Lydia ; Diepstra, Arjan ; Kok, Klaas ; van den Berg, Anke ; Kluiver, Joost. / Long Noncoding RNA Expression Profiling in Normal B-Cell Subsets and Hodgkin Lymphoma Reveals Hodgkin and Reed-Sternberg Cell Specific Long Noncoding RNAs. In: The American Journal of Pathology. 2016 ; Vol. 186, No. 9. pp. 2462-2472.

Harvard

Tayari, MM, Winkle, M, Kortman, G, Sietzema, J, de Jong, D, Terpstra, M, Mestdagh, P, Kroese, FGM, Visser, L, Diepstra, A, Kok, K, van den Berg, A & Kluiver, J 2016, 'Long Noncoding RNA Expression Profiling in Normal B-Cell Subsets and Hodgkin Lymphoma Reveals Hodgkin and Reed-Sternberg Cell Specific Long Noncoding RNAs' The American Journal of Pathology, vol. 186, no. 9, pp. 2462-2472. https://doi.org/10.1016/j.ajpath.2016.05.011

Standard

Long Noncoding RNA Expression Profiling in Normal B-Cell Subsets and Hodgkin Lymphoma Reveals Hodgkin and Reed-Sternberg Cell Specific Long Noncoding RNAs. / Tayari, Mina Masoumeh; Winkle, Melanie; Kortman, Gertrud; Sietzema, Jantine; de Jong, Debora; Terpstra, Martijn; Mestdagh, Pieter; Kroese, Frans G. M.; Visser, Lydia; Diepstra, Arjan; Kok, Klaas; van den Berg, Anke; Kluiver, Joost.

In: The American Journal of Pathology, Vol. 186, No. 9, 09.2016, p. 2462-2472.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Tayari MM, Winkle M, Kortman G, Sietzema J, de Jong D, Terpstra M et al. Long Noncoding RNA Expression Profiling in Normal B-Cell Subsets and Hodgkin Lymphoma Reveals Hodgkin and Reed-Sternberg Cell Specific Long Noncoding RNAs. The American Journal of Pathology. 2016 Sep;186(9):2462-2472. https://doi.org/10.1016/j.ajpath.2016.05.011


BibTeX

@article{3c05f835077a4b45926b60af0a37d19c,
title = "Long Noncoding RNA Expression Profiling in Normal B-Cell Subsets and Hodgkin Lymphoma Reveals Hodgkin and Reed-Sternberg Cell Specific Long Noncoding RNAs",
abstract = "Hodgkin lymphoma (HL) is a malignancy of germinal center (GC) B-cell origin. To explore the role of long noncoding RNAs (lncRNAs) in HL, we studied LncRNA expression patterns in normal B-cell subsets, HL cell lines, and tissues. Naive and memory B cells showed a highly similar lncRNA expression pattern, distinct from GC-B cells. Significant differential expression between I-IL and normal GC-B cells was observed for 475 lncRNA loci. For two validated lncRNAs, an enhanced expression was observed in HL, diffuse large 6-cell lymphoma, and lymphoblastoid cell lines. For a third lncRNA, increased expression levels were observed in HL and part of Burkitt lymphoma cell lines. RNA fluorescence in situ hybridization on primary HL tissues revealed a tumor cell specific expression pattern for all three lncRNAs. A potential cis-regulatory role was observed for 107 differentially expressed lncRNA-mRNA pairs localizing within a 60-kb region. Consistent with a cis-acting role, we showed a preferential nuclear localization for two selected candidates. Thus, we showed dynamic lncRNA expression changes during the transit of normal B cells through the pC reaction and widely deregulated lncRNA expression patterns in HL. Three lncRNAs showed a tumor cell specific expression pattern in HL tissues and might therefore be of value as a biomarker.",
keywords = "TRANSCRIPTION, DIFFERENTIATION, PATHOGENESIS, CHROMATIN, MEF2C",
author = "Tayari, {Mina Masoumeh} and Melanie Winkle and Gertrud Kortman and Jantine Sietzema and {de Jong}, Debora and Martijn Terpstra and Pieter Mestdagh and Kroese, {Frans G. M.} and Lydia Visser and Arjan Diepstra and Klaas Kok and {van den Berg}, Anke and Joost Kluiver",
note = "Copyright {\circledC} 2016 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.",
year = "2016",
month = "9",
doi = "10.1016/j.ajpath.2016.05.011",
language = "English",
volume = "186",
pages = "2462--2472",
journal = "The American Journal of Pathology",
issn = "0002-9440",
publisher = "ELSEVIER SCIENCE INC",
number = "9",

}

RIS

TY - JOUR

T1 - Long Noncoding RNA Expression Profiling in Normal B-Cell Subsets and Hodgkin Lymphoma Reveals Hodgkin and Reed-Sternberg Cell Specific Long Noncoding RNAs

AU - Tayari, Mina Masoumeh

AU - Winkle, Melanie

AU - Kortman, Gertrud

AU - Sietzema, Jantine

AU - de Jong, Debora

AU - Terpstra, Martijn

AU - Mestdagh, Pieter

AU - Kroese, Frans G. M.

AU - Visser, Lydia

AU - Diepstra, Arjan

AU - Kok, Klaas

AU - van den Berg, Anke

AU - Kluiver, Joost

N1 - Copyright © 2016 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

PY - 2016/9

Y1 - 2016/9

N2 - Hodgkin lymphoma (HL) is a malignancy of germinal center (GC) B-cell origin. To explore the role of long noncoding RNAs (lncRNAs) in HL, we studied LncRNA expression patterns in normal B-cell subsets, HL cell lines, and tissues. Naive and memory B cells showed a highly similar lncRNA expression pattern, distinct from GC-B cells. Significant differential expression between I-IL and normal GC-B cells was observed for 475 lncRNA loci. For two validated lncRNAs, an enhanced expression was observed in HL, diffuse large 6-cell lymphoma, and lymphoblastoid cell lines. For a third lncRNA, increased expression levels were observed in HL and part of Burkitt lymphoma cell lines. RNA fluorescence in situ hybridization on primary HL tissues revealed a tumor cell specific expression pattern for all three lncRNAs. A potential cis-regulatory role was observed for 107 differentially expressed lncRNA-mRNA pairs localizing within a 60-kb region. Consistent with a cis-acting role, we showed a preferential nuclear localization for two selected candidates. Thus, we showed dynamic lncRNA expression changes during the transit of normal B cells through the pC reaction and widely deregulated lncRNA expression patterns in HL. Three lncRNAs showed a tumor cell specific expression pattern in HL tissues and might therefore be of value as a biomarker.

AB - Hodgkin lymphoma (HL) is a malignancy of germinal center (GC) B-cell origin. To explore the role of long noncoding RNAs (lncRNAs) in HL, we studied LncRNA expression patterns in normal B-cell subsets, HL cell lines, and tissues. Naive and memory B cells showed a highly similar lncRNA expression pattern, distinct from GC-B cells. Significant differential expression between I-IL and normal GC-B cells was observed for 475 lncRNA loci. For two validated lncRNAs, an enhanced expression was observed in HL, diffuse large 6-cell lymphoma, and lymphoblastoid cell lines. For a third lncRNA, increased expression levels were observed in HL and part of Burkitt lymphoma cell lines. RNA fluorescence in situ hybridization on primary HL tissues revealed a tumor cell specific expression pattern for all three lncRNAs. A potential cis-regulatory role was observed for 107 differentially expressed lncRNA-mRNA pairs localizing within a 60-kb region. Consistent with a cis-acting role, we showed a preferential nuclear localization for two selected candidates. Thus, we showed dynamic lncRNA expression changes during the transit of normal B cells through the pC reaction and widely deregulated lncRNA expression patterns in HL. Three lncRNAs showed a tumor cell specific expression pattern in HL tissues and might therefore be of value as a biomarker.

KW - TRANSCRIPTION

KW - DIFFERENTIATION

KW - PATHOGENESIS

KW - CHROMATIN

KW - MEF2C

U2 - 10.1016/j.ajpath.2016.05.011

DO - 10.1016/j.ajpath.2016.05.011

M3 - Article

VL - 186

SP - 2462

EP - 2472

JO - The American Journal of Pathology

JF - The American Journal of Pathology

SN - 0002-9440

IS - 9

ER -

ID: 33860768