Publication

Localized Template-Driven Functionalization of Nanoparticles by Dynamic Combinatorial Chemistry

Nowak, P., Saggiomo, V., Salehian, F., Colomb-Delsuc, M., Han, Y. & Otto, S., 27-Mar-2015, In : Angewandte Chemie - International Edition. 54, 14, p. 4192-4197 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Nowak, P., Saggiomo, V., Salehian, F., Colomb-Delsuc, M., Han, Y., & Otto, S. (2015). Localized Template-Driven Functionalization of Nanoparticles by Dynamic Combinatorial Chemistry. Angewandte Chemie - International Edition, 54(14), 4192-4197. https://doi.org/10.1002/anie.201409667

Author

Nowak, Piotr ; Saggiomo, Vittorio ; Salehian, Fatemeh ; Colomb-Delsuc, Mathieu ; Han, Yang ; Otto, Sijbren. / Localized Template-Driven Functionalization of Nanoparticles by Dynamic Combinatorial Chemistry. In: Angewandte Chemie - International Edition. 2015 ; Vol. 54, No. 14. pp. 4192-4197.

Harvard

Nowak, P, Saggiomo, V, Salehian, F, Colomb-Delsuc, M, Han, Y & Otto, S 2015, 'Localized Template-Driven Functionalization of Nanoparticles by Dynamic Combinatorial Chemistry', Angewandte Chemie - International Edition, vol. 54, no. 14, pp. 4192-4197. https://doi.org/10.1002/anie.201409667

Standard

Localized Template-Driven Functionalization of Nanoparticles by Dynamic Combinatorial Chemistry. / Nowak, Piotr; Saggiomo, Vittorio; Salehian, Fatemeh; Colomb-Delsuc, Mathieu; Han, Yang; Otto, Sijbren.

In: Angewandte Chemie - International Edition, Vol. 54, No. 14, 27.03.2015, p. 4192-4197.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Nowak P, Saggiomo V, Salehian F, Colomb-Delsuc M, Han Y, Otto S. Localized Template-Driven Functionalization of Nanoparticles by Dynamic Combinatorial Chemistry. Angewandte Chemie - International Edition. 2015 Mar 27;54(14):4192-4197. https://doi.org/10.1002/anie.201409667


BibTeX

@article{f9a71976ca7646128043d4b0881a3f31,
title = "Localized Template-Driven Functionalization of Nanoparticles by Dynamic Combinatorial Chemistry",
abstract = "We have developed a method for the localized functionalization of gold nanoparticles using imine-based dynamic combinatorial chemistry. By using DNA templates, amines were grafted on the aldehyde-functionalized nanoparticles only if and where the nanoparticles interacted with the template molecules. Functionalization of the nanoparticles was controlled solely by the DNA template; only amines capable of interacting with DNA were bound to the surface. Interestingly, even though our libraries contained only a handful of simple amines, the DNA sequence influenced their attachment to the surface. Our method opens up new opportunities for the synthesis of multivalent, nanoparticle-based receptors for biomacromolecules.",
keywords = "dynamic combinatorial chemistry, gold nanoparticles, multivalent interactions, surface functionalization, systems chemistry, GOLD NANOPARTICLES, COVALENT CHEMISTRY, SMALL-MOLECULE, LIBRARIES, RECOGNITION, EQUILIBRATION, SURFACE, WATER, MACROCYCLES, INHIBITORS",
author = "Piotr Nowak and Vittorio Saggiomo and Fatemeh Salehian and Mathieu Colomb-Delsuc and Yang Han and Sijbren Otto",
year = "2015",
month = "3",
day = "27",
doi = "10.1002/anie.201409667",
language = "English",
volume = "54",
pages = "4192--4197",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "WILEY-V C H VERLAG GMBH",
number = "14",

}

RIS

TY - JOUR

T1 - Localized Template-Driven Functionalization of Nanoparticles by Dynamic Combinatorial Chemistry

AU - Nowak, Piotr

AU - Saggiomo, Vittorio

AU - Salehian, Fatemeh

AU - Colomb-Delsuc, Mathieu

AU - Han, Yang

AU - Otto, Sijbren

PY - 2015/3/27

Y1 - 2015/3/27

N2 - We have developed a method for the localized functionalization of gold nanoparticles using imine-based dynamic combinatorial chemistry. By using DNA templates, amines were grafted on the aldehyde-functionalized nanoparticles only if and where the nanoparticles interacted with the template molecules. Functionalization of the nanoparticles was controlled solely by the DNA template; only amines capable of interacting with DNA were bound to the surface. Interestingly, even though our libraries contained only a handful of simple amines, the DNA sequence influenced their attachment to the surface. Our method opens up new opportunities for the synthesis of multivalent, nanoparticle-based receptors for biomacromolecules.

AB - We have developed a method for the localized functionalization of gold nanoparticles using imine-based dynamic combinatorial chemistry. By using DNA templates, amines were grafted on the aldehyde-functionalized nanoparticles only if and where the nanoparticles interacted with the template molecules. Functionalization of the nanoparticles was controlled solely by the DNA template; only amines capable of interacting with DNA were bound to the surface. Interestingly, even though our libraries contained only a handful of simple amines, the DNA sequence influenced their attachment to the surface. Our method opens up new opportunities for the synthesis of multivalent, nanoparticle-based receptors for biomacromolecules.

KW - dynamic combinatorial chemistry

KW - gold nanoparticles

KW - multivalent interactions

KW - surface functionalization

KW - systems chemistry

KW - GOLD NANOPARTICLES

KW - COVALENT CHEMISTRY

KW - SMALL-MOLECULE

KW - LIBRARIES

KW - RECOGNITION

KW - EQUILIBRATION

KW - SURFACE

KW - WATER

KW - MACROCYCLES

KW - INHIBITORS

U2 - 10.1002/anie.201409667

DO - 10.1002/anie.201409667

M3 - Article

VL - 54

SP - 4192

EP - 4197

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 14

ER -

ID: 20849400