Localized Template-Driven Functionalization of Nanoparticles by Dynamic Combinatorial Chemistry

Nowak, P., Saggiomo, V., Salehian, F., Colomb-Delsuc, M., Han, Y. & Otto, S., 27-Mar-2015, In : Angewandte Chemie - International Edition. 54, 14, p. 4192-4197 6 p.

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  • Localized Template-Driven Functionalization of Nanoparticles by Dynamic

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  • Piotr Nowak
  • Vittorio Saggiomo
  • Fatemeh Salehian
  • Mathieu Colomb-Delsuc
  • Yang Han
  • Sijbren Otto

We have developed a method for the localized functionalization of gold nanoparticles using imine-based dynamic combinatorial chemistry. By using DNA templates, amines were grafted on the aldehyde-functionalized nanoparticles only if and where the nanoparticles interacted with the template molecules. Functionalization of the nanoparticles was controlled solely by the DNA template; only amines capable of interacting with DNA were bound to the surface. Interestingly, even though our libraries contained only a handful of simple amines, the DNA sequence influenced their attachment to the surface. Our method opens up new opportunities for the synthesis of multivalent, nanoparticle-based receptors for biomacromolecules.

Original languageEnglish
Pages (from-to)4192-4197
Number of pages6
JournalAngewandte Chemie - International Edition
Issue number14
Publication statusPublished - 27-Mar-2015


  • dynamic combinatorial chemistry, gold nanoparticles, multivalent interactions, surface functionalization, systems chemistry, GOLD NANOPARTICLES, COVALENT CHEMISTRY, SMALL-MOLECULE, LIBRARIES, RECOGNITION, EQUILIBRATION, SURFACE, WATER, MACROCYCLES, INHIBITORS

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