Publication

Liver retransplantation in adult recipients: analysis of a 38-year experience in the Netherlands

Takagi, K., Domagala, P., Porte, R. J., Alwayn, I., Metselaar, H. J., van den Berg, A. P., van Hoek, B., Ijzermans, J. N. M. & Polak, W. G., Jan-2020, In : Journal of hepato-Biliary-Pancreatic sciences. 27, 1, p. 26-33 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Background Liver retransplantation (re-LT) accounts for up to 22% after primary liver transplantation (LT), and using donor livers for retransplantation can only be justified by successful outcomes. Methods A total of 2,387 adult recipients with 2,778 LT, between 1979 and 2017, were analyzed to determine risk factors and outcome of re-LT in the Netherlands. Results Of 2,778 LT, 336 (12.1%) were first, 43 (1.5%) were second, and 12 (0.5%) were third or fourth re-LT. The 5-year patient survival for primary LT, and first, second, and third or fourth re-LT were 74.0%, 70.8%, 63.3%, and 57.1%, respectively (P = 0.10). Recipient age (9 h) (OR 1.42, P = 0.007) were significant risk factors for retransplantation after primary LT. Conclusions Recipient age, era, DCD, and prolonged CIT were identified as parameters for retransplantation. The outcome after the first re-LT was good, and comparable to those of primary transplants. Survival after multiple re-LT was not significantly different from the first retransplant group, legitimizing third and fourth re-LT to well-selected patients.

Original languageEnglish
Pages (from-to)26-33
Number of pages8
JournalJournal of hepato-Biliary-Pancreatic sciences
Volume27
Issue number1
Publication statusPublished - Jan-2020

    Keywords

  • Liver retransplantation, Outcome, LONG-TERM SURVIVAL, CIRCULATORY DEATH, SINGLE-CENTER, TRANSPLANTATION, DONATION, TIME, CRITERIA, OUTCOMES

ID: 118088419