Publication

Linking genetic variants of the mineralocorticoid receptor and negative memory bias: Interaction with prior life adversity

Vogel, S., Gerritsen, L., van Oostrom, I., Arias-Vasquez, A., Rijpkema, M., Joels, M., Franke, B., Tendolkar, I. & Fernandez, G., Feb-2014, In : Psychoneuroendocrinology. 40, p. 181-190 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Vogel, S., Gerritsen, L., van Oostrom, I., Arias-Vasquez, A., Rijpkema, M., Joels, M., Franke, B., Tendolkar, I., & Fernandez, G. (2014). Linking genetic variants of the mineralocorticoid receptor and negative memory bias: Interaction with prior life adversity. Psychoneuroendocrinology, 40, 181-190. https://doi.org/10.1016/j.psyneuen.2013.11.010

Author

Vogel, Susanne ; Gerritsen, Lotte ; van Oostrom, Iris ; Arias-Vasquez, Alejandro ; Rijpkema, Mark ; Joels, Marian ; Franke, Barbara ; Tendolkar, Indira ; Fernandez, Guillen. / Linking genetic variants of the mineralocorticoid receptor and negative memory bias : Interaction with prior life adversity. In: Psychoneuroendocrinology. 2014 ; Vol. 40. pp. 181-190.

Harvard

Vogel, S, Gerritsen, L, van Oostrom, I, Arias-Vasquez, A, Rijpkema, M, Joels, M, Franke, B, Tendolkar, I & Fernandez, G 2014, 'Linking genetic variants of the mineralocorticoid receptor and negative memory bias: Interaction with prior life adversity', Psychoneuroendocrinology, vol. 40, pp. 181-190. https://doi.org/10.1016/j.psyneuen.2013.11.010

Standard

Linking genetic variants of the mineralocorticoid receptor and negative memory bias : Interaction with prior life adversity. / Vogel, Susanne; Gerritsen, Lotte; van Oostrom, Iris; Arias-Vasquez, Alejandro; Rijpkema, Mark; Joels, Marian; Franke, Barbara; Tendolkar, Indira; Fernandez, Guillen.

In: Psychoneuroendocrinology, Vol. 40, 02.2014, p. 181-190.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Vogel S, Gerritsen L, van Oostrom I, Arias-Vasquez A, Rijpkema M, Joels M et al. Linking genetic variants of the mineralocorticoid receptor and negative memory bias: Interaction with prior life adversity. Psychoneuroendocrinology. 2014 Feb;40:181-190. https://doi.org/10.1016/j.psyneuen.2013.11.010


BibTeX

@article{4a4092a54bbf4d3eb1b4d45f2bc9f051,
title = "Linking genetic variants of the mineralocorticoid receptor and negative memory bias: Interaction with prior life adversity",
abstract = "Substantial research has been conducted investigating the association between life adversity and genetic vulnerability for depression, but clear mechanistic links are rarely identified and investigation often focused on single genetic variants. Complex phenotypes like depression, however, are likely determined by multiple variants in interaction with environmental factors. As variations in the mineralocorticoid receptor gene (NR3C2) have been related to a higher risk for depression, we investigated whether NR3C2 variance is related to negative memory bias, an established endophenotype for depression, in healthy participants. Furthermore, we explored the influence of life adversity on this association.We used a set-based analysis to simultaneously test all measured variation in NR3C2 for an association with negative memory bias in 483 participants and an interaction with life adversity. To further specify this interaction, we split the sample into low and high live adversity groups and repeated the analyses in both groups separately.NR3C2 variance was associated with negative memory bias, especially in the high life adversity group. Additionally, we identified a functional polymorphism (rs5534) related to negative memory bias and demonstrating a gene x life adversity interaction.Variations in NR3C2 are associated with negative memory bias and this relationship appears to be influenced by life adversity. As negative memory bias is implicated in the susceptibility to depression, our findings provide mechanistic support for the notion that variations in NR3C2 - which could compromise the proper function of this receptor - are a risk factor for the development of mood disorders. (C) 2013 Elsevier Ltd. All rights reserved.",
keywords = "Mineralocorticoid receptor, NR3C2, Memory bias, Gene x life adversity interaction, MAJOR DEPRESSIVE DISORDER, DOMINANT PSEUDOHYPOALDOSTERONISM TYPE-1, GLUCOCORTICOID-RECEPTORS, THREATENING EXPERIENCES, HIPPOCAMPAL VOLUME, ASSOCIATION, VULNERABILITY, INFORMATION, STRESS, POLYMORPHISMS",
author = "Susanne Vogel and Lotte Gerritsen and {van Oostrom}, Iris and Alejandro Arias-Vasquez and Mark Rijpkema and Marian Joels and Barbara Franke and Indira Tendolkar and Guillen Fernandez",
year = "2014",
month = feb,
doi = "10.1016/j.psyneuen.2013.11.010",
language = "English",
volume = "40",
pages = "181--190",
journal = "Psychoneuroendocrinology",
issn = "0306-4530",
publisher = "PERGAMON-ELSEVIER SCIENCE LTD",

}

RIS

TY - JOUR

T1 - Linking genetic variants of the mineralocorticoid receptor and negative memory bias

T2 - Interaction with prior life adversity

AU - Vogel, Susanne

AU - Gerritsen, Lotte

AU - van Oostrom, Iris

AU - Arias-Vasquez, Alejandro

AU - Rijpkema, Mark

AU - Joels, Marian

AU - Franke, Barbara

AU - Tendolkar, Indira

AU - Fernandez, Guillen

PY - 2014/2

Y1 - 2014/2

N2 - Substantial research has been conducted investigating the association between life adversity and genetic vulnerability for depression, but clear mechanistic links are rarely identified and investigation often focused on single genetic variants. Complex phenotypes like depression, however, are likely determined by multiple variants in interaction with environmental factors. As variations in the mineralocorticoid receptor gene (NR3C2) have been related to a higher risk for depression, we investigated whether NR3C2 variance is related to negative memory bias, an established endophenotype for depression, in healthy participants. Furthermore, we explored the influence of life adversity on this association.We used a set-based analysis to simultaneously test all measured variation in NR3C2 for an association with negative memory bias in 483 participants and an interaction with life adversity. To further specify this interaction, we split the sample into low and high live adversity groups and repeated the analyses in both groups separately.NR3C2 variance was associated with negative memory bias, especially in the high life adversity group. Additionally, we identified a functional polymorphism (rs5534) related to negative memory bias and demonstrating a gene x life adversity interaction.Variations in NR3C2 are associated with negative memory bias and this relationship appears to be influenced by life adversity. As negative memory bias is implicated in the susceptibility to depression, our findings provide mechanistic support for the notion that variations in NR3C2 - which could compromise the proper function of this receptor - are a risk factor for the development of mood disorders. (C) 2013 Elsevier Ltd. All rights reserved.

AB - Substantial research has been conducted investigating the association between life adversity and genetic vulnerability for depression, but clear mechanistic links are rarely identified and investigation often focused on single genetic variants. Complex phenotypes like depression, however, are likely determined by multiple variants in interaction with environmental factors. As variations in the mineralocorticoid receptor gene (NR3C2) have been related to a higher risk for depression, we investigated whether NR3C2 variance is related to negative memory bias, an established endophenotype for depression, in healthy participants. Furthermore, we explored the influence of life adversity on this association.We used a set-based analysis to simultaneously test all measured variation in NR3C2 for an association with negative memory bias in 483 participants and an interaction with life adversity. To further specify this interaction, we split the sample into low and high live adversity groups and repeated the analyses in both groups separately.NR3C2 variance was associated with negative memory bias, especially in the high life adversity group. Additionally, we identified a functional polymorphism (rs5534) related to negative memory bias and demonstrating a gene x life adversity interaction.Variations in NR3C2 are associated with negative memory bias and this relationship appears to be influenced by life adversity. As negative memory bias is implicated in the susceptibility to depression, our findings provide mechanistic support for the notion that variations in NR3C2 - which could compromise the proper function of this receptor - are a risk factor for the development of mood disorders. (C) 2013 Elsevier Ltd. All rights reserved.

KW - Mineralocorticoid receptor

KW - NR3C2

KW - Memory bias

KW - Gene x life adversity interaction

KW - MAJOR DEPRESSIVE DISORDER

KW - DOMINANT PSEUDOHYPOALDOSTERONISM TYPE-1

KW - GLUCOCORTICOID-RECEPTORS

KW - THREATENING EXPERIENCES

KW - HIPPOCAMPAL VOLUME

KW - ASSOCIATION

KW - VULNERABILITY

KW - INFORMATION

KW - STRESS

KW - POLYMORPHISMS

U2 - 10.1016/j.psyneuen.2013.11.010

DO - 10.1016/j.psyneuen.2013.11.010

M3 - Article

VL - 40

SP - 181

EP - 190

JO - Psychoneuroendocrinology

JF - Psychoneuroendocrinology

SN - 0306-4530

ER -

ID: 37891164