Lifelines NEXT: a prospective birth cohort adding the next generation to the three-generation Lifelines cohort studyWarmink-Perdijk, W. D. B., Peters, L. L., Tigchelaar, E. F., Dekens, J. A. M., Jankipersadsing, S. A., Zhernakova, A., Bossers, W. J. R., Sikkema, J., de Jonge, A., Reijneveld, S. A., Verkade, H. J., Koppelman, G. H., Wijmenga, C., Kuipers, F. & Scherjon, S. A., 25-Feb-2020, In : European Journal of Epidemiology. 35, 2, p. 157-168 12 p.
Research output: Contribution to journal › Article › Academic › peer-review
- Translational Immunology Groningen (TRIGR)
- Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI)
- Public Health Research (PHR)
- Lifestyle Medicine (LM)
- Center for Liver, Digestive and Metabolic Diseases (CLDM)
- Groningen Research Institute for Asthma and COPD (GRIAC)
- Department of Health and Life Sciences
- Reproductive Origins of Adult Health and Disease (ROAHD)
Epidemiological research has shown there to be a strong relationship between preconceptional, prenatal, birth and early-life factors and lifelong health. The Lifelines NEXT is a birth cohort designed to study the effects of intrinsic and extrinsic determinants on health and disease in a four-generation design. It is embedded within the Lifelines cohort study, a prospective three-generation population-based cohort study recording the health and health-related aspects of 167,729 individuals living in Northern Netherlands. In Lifelines NEXT we aim to include 1500 pregnant Lifelines participants and intensively follow them, their partners and their children until at least 1 year after birth. Longer-term follow-up of physical and psychological health will then be embedded following Lifelines procedures. During the Lifelines NEXT study period biomaterials-including maternal and neonatal (cord) blood, placental tissue, feces, breast milk, nasal swabs and urine-will be collected from the mother and child at 10 time points. We will also collect data on medical, social, lifestyle and environmental factors via questionnaires at 14 different time points and continuous data via connected devices. The extensive collection of different (bio)materials from mother and child during pregnancy and afterwards will provide the means to relate environmental factors including maternal and neonatal microbiome composition) to (epi)genetics, health and developmental outcomes. The nesting of the study within Lifelines enables us to include preconceptional transgenerational data and can be used to identify other extended families within the cohort.
|Number of pages||12|
|Journal||European Journal of Epidemiology|
|Publication status||Published - 25-Feb-2020|
- Biobank, Birth cohort, Prospective study, Microbiome, Transgenerational effects, Developmental Origins of Health and Disease (DOHaD), THREATENING EXPERIENCES, METABOLIC DISEASE, DNA METHYLATION, LUNG-FUNCTION, VALIDATION, QUESTIONNAIRE, PREGNANCY, LIFE, CHOLESTASIS, NUTRITION