Lewis acid promoted dearomatization of naphtholsHarutyunyan, S. R., Kulish, K., Boldrini, C., Castiñeira Reis, M. & Pérez, J., 22-Sep-2020, In : Chemistry. 68, p. 15843-15846
Research output: Contribution to journal › Article › Academic › peer-review
Here we report two-step dearomative functionalization of naphthols promoted by Lewis acids and copper(I) catalysis. Initially, Lewis acid complexation inverses the electronic properties of the ring and establishes an equilibrium with the dearomatized counterpart. Subsequent trapping of the dearomatized intermediate with organometallics as well as organophosphines is demonstrated and provides the corresponding dearomatized products.
|Publication status||E-pub ahead of print - 22-Sep-2020|