Lewis acid promoted dearomatization of naphthols

Harutyunyan, S. R., Kulish, K., Boldrini, C., Castiñeira Reis, M. & Pérez, J., 22-Sep-2020, In : Chemistry. 68, p. 15843-15846

Research output: Contribution to journalArticleAcademicpeer-review

Here we report two-step dearomative functionalization of naphthols promoted by Lewis acids and copper(I) catalysis. Initially, Lewis acid complexation inverses the electronic properties of the ring and establishes an equilibrium with the dearomatized counterpart. Subsequent trapping of the dearomatized intermediate with organometallics as well as organophosphines is demonstrated and provides the corresponding dearomatized products.

Original languageEnglish
Pages (from-to)15843-15846
Issue number68
Publication statusE-pub ahead of print - 22-Sep-2020

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