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Leveraging European European infrastructures to access 1 million human genomes by 2022

Saunders, G., Baudis, M., Becker, R., Beltran, S., Béroud, C., Birney, E., Brooksbank, C., Brunak, S., Van den Bulcke, M., Drysdale, R., Capella-Gutierrez, S., Flicek, P., Florindi, F., Goodhand, P., Gut, I., Heringa, J., Holub, P., Hooyberghs, J., Juty, N., Keane, T. M., Korbel, J. O., Lappalainen, I., Leskosek, B., Matthijs, G., Mayrhofer, M. T., Metspalu, A., Navarro, A., Newhouse, S., Nyrönen, T., Page, A., Persson, B., Palotie, A., Parkinson, H., Rambla, J., Salgado, D., Steinfelder, E., Swertz, M. A., Valencia, A., Varma, S., Blomberg, N. & Scollen, S., Nov-2019, In : Nature Reviews Genetics. 20, 11, p. 692-701 9 p.

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  • Leveraging European infrastructures

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DOI

  • Gary Saunders
  • Michael Baudis
  • Regina Becker
  • Sergi Beltran
  • Christophe Béroud
  • Ewan Birney
  • Cath Brooksbank
  • Søren Brunak
  • Marc Van den Bulcke
  • Rachel Drysdale
  • Salvador Capella-Gutierrez
  • Paul Flicek
  • Francesco Florindi
  • Peter Goodhand
  • Ivo Gut
  • Jaap Heringa
  • Petr Holub
  • Jef Hooyberghs
  • Nick Juty
  • Thomas M Keane
  • Jan O Korbel
  • Ilkka Lappalainen
  • Brane Leskosek
  • Gert Matthijs
  • Michaela Th Mayrhofer
  • Andres Metspalu
  • Arcadi Navarro
  • Steven Newhouse
  • Tommi Nyrönen
  • Angela Page
  • Bengt Persson
  • Aarno Palotie
  • Helen Parkinson
  • Jordi Rambla
  • David Salgado
  • Erik Steinfelder
  • Morris A Swertz
  • Alfonso Valencia
  • Susheel Varma
  • Niklas Blomberg
  • Serena Scollen

Human genomics is undergoing a step change from being a predominantly research-driven activity to one driven through health care as many countries in Europe now have nascent precision medicine programmes. To maximize the value of the genomic data generated, these data will need to be shared between institutions and across countries. In recognition of this challenge, 21 European countries recently signed a declaration to transnationally share data on at least 1 million human genomes by 2022. In this Roadmap, we identify the challenges of data sharing across borders and demonstrate that European research infrastructures are well-positioned to support the rapid implementation of widespread genomic data access.

Original languageEnglish
Pages (from-to)692-701
Number of pages9
JournalNature Reviews Genetics
Volume20
Issue number11
Early online date27-Aug-2019
Publication statusPublished - Nov-2019

    Keywords

  • BIG DATA

ID: 95169019