Left ventricular hypertrophy: virtuous intentions, malign consequences

Pokharel, S., Sharma, UC. & Pinto, YM., Jun-2003, In : International journal of biochemistry & cell biology. 35, 6, p. 802-806 5 p., PII S1357-2725(02)00344-8.

Research output: Contribution to journalArticleAcademicpeer-review

  • S Pokharel
  • UC Sharma
  • YM Pinto

Left ventricular hypertrophy (LVH) is currently the focus of intense cardiovascular research, with the resultant rapid evolution of novel concepts relating to its exceedingly complex pathophysiology. In addition to the alterations in signal transduction and disturbances in Ca2+ homeostasis, there are structural changes in myofilaments, disorganization of the cytoskeletal framework and increased collagen synthesis. LVH is associated with progressive left ventricular remodeling that culminates to heart failure. The modern treatment of left ventricular hypertrophy is now largely based on the hypothesis that neuroendocrine activation is important in the progression of the disease and inhibition of neurohormones is likely to have long-term benefit with regard to morbidity and mortality. Drugs specifically designed to unload the left ventricle, such as diuretics and vasodilators, appears to be less effective in reducing LV mass and improving prognosis. Thus, the evolution of treatment for LVH itself has provided much enlightenment for our understanding of the fundamental biology of the disorder. (C) 2003 Published by Elsevier Science Ltd.

Original languageEnglish
Article numberPII S1357-2725(02)00344-8
Pages (from-to)802-806
Number of pages5
JournalInternational journal of biochemistry & cell biology
Issue number6
Publication statusPublished - Jun-2003


  • hypertrophy, heart failures, neurohormone, CARDIAC-HYPERTROPHY, MECHANISMS, PRESSURE, FAILURE, MODELS, RAT

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