Publication

Left ventricular dilatation after myocardial infarction: ACE inhibitors, beta-blockers or both

Anthonio, RL., van Veldhuisen, DJ. & van Gilst, WH., 1998, In : Journal of Cardiovascular Pharmacology. 32, p. S1-S8 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Left ventricular (LV) dilatation after myocardial infarction (MI) is a major predictor of prognosis and identifies which patients will develop heart failure. Left dilatation or remodeling starts immediately after MI and progresses in the chronic phase of heart failure. Factors influencing remodeling, such as infarct size and neurohumoral activation, including the sympathetic and renin-angiotensin system, are discussed. Remodeling can be affected by reduction of infarct size and inhibition of neurohumoral activation. The effect of thrombolysis, beta-blockade, and angiotensin-converting enzyme (ACE) inhibition in the acute phase after MI and in the chronic phase of heart failure on remodeling are discussed. On the basis of beneficial effects of ACE inhibition and beta-blockade in acute MI and in chronic heart failure, a treatment strategy is proposed in which both ACE inhibition and beta-blockade are started early after MI. Depending on infarct size and ventricular function, continued treatment in the chronic phase of heart failure must be considered.

Original languageEnglish
Pages (from-to)S1-S8
Number of pages8
JournalJournal of Cardiovascular Pharmacology
Volume32
Publication statusPublished - 1998
EventSymposium on Treatment of Heart Failure - Current Insights and New Treatment Options - , Netherlands
Duration: 31-May-1997 → …

Event

Symposium on Treatment of Heart Failure - Current Insights and New Treatment Options

31/05/1997 → …

Netherlands

Event: Other

    Keywords

  • left ventricular dilatation, remodeling, myocardial infarction, neurohumoral activation, chronic heart failure, beta-blockade, ACE inhibition, beta-blocker treatment, ACE inhibitor treatment, ANGIOTENSIN-CONVERTING-ENZYME, TWO-DIMENSIONAL ECHOCARDIOGRAPHY, CONGESTIVE-HEART-FAILURE, FAILING HUMAN HEART, DELETION POLYMORPHISM, THROMBOLYTIC THERAPY, REPERFUSION INJURY, RAT-HEART, FOLLOW-UP, CAPTOPRIL

ID: 3745386