Learning from Parkinson's patients: Usability of the Cyclops dry powder inhaler

Luinstra, M., Isufi, V., de Jong, L., Rutgers, A. W. F., Hagedoorn, P., Puttenstein, J., van Laar, T. & Frijlink, H. W., 15-Aug-2019, In : International Journal of Pharmaceutics. 567, p. 118493 5 p., 118493.

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  • Learning from Parkinson’s patients: Usability of the Cyclops dry powderinhaler

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Effective inhaler therapy requires correct handling of the inhaler, including being able to prepare the inhaler for use. Motor function impairment and cognitive disabilities, may impose problems on patients with Parkinson's disease when they have to prepare medication, such as inhalers, for use. The aim of the present study was to examine whether Parkinson's patients are able to correctly prepare the Cyclops inhaler for use. At first, 12 patients, 6 in an off state and 6 in an on state, were asked to open 5 inhalers with ascending peel resistance of the cover foil. It was investigated up to which peel resistance they were able to successfully pull the foil from the inhaler. For the second part of the study, 48 participants, 24 on and 24 off, were asked to open 2 pouches and the 2 inhalers selected in part 1. For pouch 1, 70.8% of the patients in an on state and 58.3% in an off state were able to open the pouch correctly. For pouch 2, this was 79.2% and 75.0%, respectively. Both Cyclops inhalers were opened correctly by 95.8% of the participants in the on state and 91.7% of the participants in the off state.

Original languageEnglish
Article number118493
Pages (from-to)118493
Number of pages5
JournalInternational Journal of Pharmaceutics
Early online date3-Jul-2019
Publication statusPublished - 15-Aug-2019


  • Parkinson's disease, Usability, Inhaler, Patient satisfaction, DESIGN, FOOD

ID: 90643908