Publication

Large-scale electron microscopy database for human type 1 diabetes

de Boer, P., Pirozzi, N. M., Wolters, A. H. G., Kuipers, J., Kusmartseva, I., Atkinson, M. A., Campbell-Thompson, M. & Giepmans, B. N. G., 18-May-2020, In : Nature Communications. 11, 1, 9 p., 2475.

Research output: Contribution to journalArticleAcademicpeer-review

APA

de Boer, P., Pirozzi, N. M., Wolters, A. H. G., Kuipers, J., Kusmartseva, I., Atkinson, M. A., ... Giepmans, B. N. G. (2020). Large-scale electron microscopy database for human type 1 diabetes. Nature Communications, 11(1), [2475]. https://doi.org/10.1038/s41467-020-16287-5

Author

de Boer, Pascal ; Pirozzi, Nicole M ; Wolters, Anouk H G ; Kuipers, Jeroen ; Kusmartseva, Irina ; Atkinson, Mark A ; Campbell-Thompson, Martha ; Giepmans, Ben N G. / Large-scale electron microscopy database for human type 1 diabetes. In: Nature Communications. 2020 ; Vol. 11, No. 1.

Harvard

de Boer, P, Pirozzi, NM, Wolters, AHG, Kuipers, J, Kusmartseva, I, Atkinson, MA, Campbell-Thompson, M & Giepmans, BNG 2020, 'Large-scale electron microscopy database for human type 1 diabetes', Nature Communications, vol. 11, no. 1, 2475. https://doi.org/10.1038/s41467-020-16287-5

Standard

Large-scale electron microscopy database for human type 1 diabetes. / de Boer, Pascal; Pirozzi, Nicole M; Wolters, Anouk H G; Kuipers, Jeroen; Kusmartseva, Irina; Atkinson, Mark A; Campbell-Thompson, Martha; Giepmans, Ben N G.

In: Nature Communications, Vol. 11, No. 1, 2475, 18.05.2020.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

de Boer P, Pirozzi NM, Wolters AHG, Kuipers J, Kusmartseva I, Atkinson MA et al. Large-scale electron microscopy database for human type 1 diabetes. Nature Communications. 2020 May 18;11(1). 2475. https://doi.org/10.1038/s41467-020-16287-5


BibTeX

@article{f895edbd514b439e81d5ed242051e87c,
title = "Large-scale electron microscopy database for human type 1 diabetes",
abstract = "Autoimmune β-cell destruction leads to type 1 diabetes, but the pathophysiological mechanisms remain unclear. To help address this void, we created an open-access online repository, unprecedented in its size, composed of large-scale electron microscopy images ('nanotomy') of human pancreas tissue obtained from the Network for Pancreatic Organ donors with Diabetes (nPOD; www.nanotomy.org). Nanotomy allows analyses of complete donor islets with up to macromolecular resolution. Anomalies we found in type 1 diabetes included (i) an increase of 'intermediate cells' containing granules resembling those of exocrine zymogen and endocrine hormone secreting cells; and (ii) elevated presence of innate immune cells. These are our first results of mining the database and support recent findings that suggest that type 1 diabetes includes abnormalities in the exocrine pancreas that may induce endocrine cellular stress as a trigger for autoimmunity.",
author = "{de Boer}, Pascal and Pirozzi, {Nicole M} and Wolters, {Anouk H G} and Jeroen Kuipers and Irina Kusmartseva and Atkinson, {Mark A} and Martha Campbell-Thompson and Giepmans, {Ben N G}",
year = "2020",
month = "5",
day = "18",
doi = "10.1038/s41467-020-16287-5",
language = "English",
volume = "11",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Large-scale electron microscopy database for human type 1 diabetes

AU - de Boer, Pascal

AU - Pirozzi, Nicole M

AU - Wolters, Anouk H G

AU - Kuipers, Jeroen

AU - Kusmartseva, Irina

AU - Atkinson, Mark A

AU - Campbell-Thompson, Martha

AU - Giepmans, Ben N G

PY - 2020/5/18

Y1 - 2020/5/18

N2 - Autoimmune β-cell destruction leads to type 1 diabetes, but the pathophysiological mechanisms remain unclear. To help address this void, we created an open-access online repository, unprecedented in its size, composed of large-scale electron microscopy images ('nanotomy') of human pancreas tissue obtained from the Network for Pancreatic Organ donors with Diabetes (nPOD; www.nanotomy.org). Nanotomy allows analyses of complete donor islets with up to macromolecular resolution. Anomalies we found in type 1 diabetes included (i) an increase of 'intermediate cells' containing granules resembling those of exocrine zymogen and endocrine hormone secreting cells; and (ii) elevated presence of innate immune cells. These are our first results of mining the database and support recent findings that suggest that type 1 diabetes includes abnormalities in the exocrine pancreas that may induce endocrine cellular stress as a trigger for autoimmunity.

AB - Autoimmune β-cell destruction leads to type 1 diabetes, but the pathophysiological mechanisms remain unclear. To help address this void, we created an open-access online repository, unprecedented in its size, composed of large-scale electron microscopy images ('nanotomy') of human pancreas tissue obtained from the Network for Pancreatic Organ donors with Diabetes (nPOD; www.nanotomy.org). Nanotomy allows analyses of complete donor islets with up to macromolecular resolution. Anomalies we found in type 1 diabetes included (i) an increase of 'intermediate cells' containing granules resembling those of exocrine zymogen and endocrine hormone secreting cells; and (ii) elevated presence of innate immune cells. These are our first results of mining the database and support recent findings that suggest that type 1 diabetes includes abnormalities in the exocrine pancreas that may induce endocrine cellular stress as a trigger for autoimmunity.

U2 - 10.1038/s41467-020-16287-5

DO - 10.1038/s41467-020-16287-5

M3 - Article

C2 - 32424134

VL - 11

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 2475

ER -

ID: 126332706