Publication

Large normal-range TBP and ATXN7 CAG repeat lengths are associated with increased lifetime risk of depression

Gardiner, S. L., van Belzen, M. J., Boogaard, M. W., van Roon-Mom, W. M. C., Rozing, P. M., van Hemert, A. M., Smit, J. H., Beekman, A. T. F., van Grootheest, G., Schoevers, R. A., Voshaar, R. C. O., Comijs, H. C., Penninx, B. W. J. H., van der Mast, R. C., Roos, R. A. C. & Aziz, N. A., 6-Jun-2017, In : Translational Psychiatry. 7, 7 p., e1143.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Gardiner, S. L., van Belzen, M. J., Boogaard, M. W., van Roon-Mom, W. M. C., Rozing, P. M., van Hemert, A. M., ... Aziz, N. A. (2017). Large normal-range TBP and ATXN7 CAG repeat lengths are associated with increased lifetime risk of depression. Translational Psychiatry, 7, [e1143]. https://doi.org/10.1038/tp.2017.116

Author

Gardiner, S. L. ; van Belzen, M. J. ; Boogaard, M. W. ; van Roon-Mom, W. M. C. ; Rozing, P.M. ; van Hemert, A. M. ; Smit, J. H. ; Beekman, A. T. F. ; van Grootheest, Gerard ; Schoevers, R. A. ; Voshaar, R. C. Oude ; Comijs, H. C. ; Penninx, B. W. J. H. ; van der Mast, R. C. ; Roos, R. A. C. ; Aziz, N. A. / Large normal-range TBP and ATXN7 CAG repeat lengths are associated with increased lifetime risk of depression. In: Translational Psychiatry. 2017 ; Vol. 7.

Harvard

Gardiner, SL, van Belzen, MJ, Boogaard, MW, van Roon-Mom, WMC, Rozing, PM, van Hemert, AM, Smit, JH, Beekman, ATF, van Grootheest, G, Schoevers, RA, Voshaar, RCO, Comijs, HC, Penninx, BWJH, van der Mast, RC, Roos, RAC & Aziz, NA 2017, 'Large normal-range TBP and ATXN7 CAG repeat lengths are associated with increased lifetime risk of depression', Translational Psychiatry, vol. 7, e1143. https://doi.org/10.1038/tp.2017.116

Standard

Large normal-range TBP and ATXN7 CAG repeat lengths are associated with increased lifetime risk of depression. / Gardiner, S. L.; van Belzen, M. J.; Boogaard, M. W.; van Roon-Mom, W. M. C.; Rozing, P.M.; van Hemert, A. M.; Smit, J. H.; Beekman, A. T. F.; van Grootheest, Gerard; Schoevers, R. A.; Voshaar, R. C. Oude; Comijs, H. C.; Penninx, B. W. J. H.; van der Mast, R. C.; Roos, R. A. C.; Aziz, N. A.

In: Translational Psychiatry, Vol. 7, e1143, 06.06.2017.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Gardiner SL, van Belzen MJ, Boogaard MW, van Roon-Mom WMC, Rozing PM, van Hemert AM et al. Large normal-range TBP and ATXN7 CAG repeat lengths are associated with increased lifetime risk of depression. Translational Psychiatry. 2017 Jun 6;7. e1143. https://doi.org/10.1038/tp.2017.116


BibTeX

@article{446829af7fd2410eab4339e5895ca6dc,
title = "Large normal-range TBP and ATXN7 CAG repeat lengths are associated with increased lifetime risk of depression",
abstract = "Depression is one of the most prevalent and debilitating psychiatric disorders worldwide. Recently, we showed that both relatively short and relatively long cytosine-adenine-guanine (CAG) repeats in the huntingtin gene (HTT) are associated with an increased risk of lifetime depression. However, to what extent the variations in CAG repeat length in the other eight polyglutamine disease-associated genes (PDAGs) are associated with depression is still unknown. We determined the CAG repeat sizes of ATXN1, ATXN2, ATXN3, CACNA1A, ATXN7, TBP, ATN1 and AR in two well-characterized Dutch cohorts-the Netherlands Study of Depression and Anxiety and the Netherlands Study of Depression in Older Persons-including 2165 depressed and 1058 non-depressed individuals-aged 18-93 years. The association between PDAG CAG repeat size and the risk for depression was assessed via binary logistic regression. We found that the odds ratio (OR) for lifetime depression was significantly higher for individuals with >10, compared with subjects with",
keywords = "DOMINANT CEREBELLAR-ATAXIA, MACHADO-JOSEPH-DISEASE, TATA-BINDING PROTEIN, RNA-POLYMERASE-II, SIMPLE SEQUENCE REPEATS, SPINOCEREBELLAR ATAXIA, TRINUCLEOTIDE REPEAT, MAJOR DEPRESSION, POLYGLUTAMINE EXPANSIONS, CLINICAL-MANIFESTATION",
author = "Gardiner, {S. L.} and {van Belzen}, {M. J.} and Boogaard, {M. W.} and {van Roon-Mom}, {W. M. C.} and P.M. Rozing and {van Hemert}, {A. M.} and Smit, {J. H.} and Beekman, {A. T. F.} and {van Grootheest}, Gerard and Schoevers, {R. A.} and Voshaar, {R. C. Oude} and Comijs, {H. C.} and Penninx, {B. W. J. H.} and {van der Mast}, {R. C.} and Roos, {R. A. C.} and Aziz, {N. A.}",
year = "2017",
month = "6",
day = "6",
doi = "10.1038/tp.2017.116",
language = "English",
volume = "7",
journal = "Translational Psychiatry",
issn = "2158-3188",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Large normal-range TBP and ATXN7 CAG repeat lengths are associated with increased lifetime risk of depression

AU - Gardiner, S. L.

AU - van Belzen, M. J.

AU - Boogaard, M. W.

AU - van Roon-Mom, W. M. C.

AU - Rozing, P.M.

AU - van Hemert, A. M.

AU - Smit, J. H.

AU - Beekman, A. T. F.

AU - van Grootheest, Gerard

AU - Schoevers, R. A.

AU - Voshaar, R. C. Oude

AU - Comijs, H. C.

AU - Penninx, B. W. J. H.

AU - van der Mast, R. C.

AU - Roos, R. A. C.

AU - Aziz, N. A.

PY - 2017/6/6

Y1 - 2017/6/6

N2 - Depression is one of the most prevalent and debilitating psychiatric disorders worldwide. Recently, we showed that both relatively short and relatively long cytosine-adenine-guanine (CAG) repeats in the huntingtin gene (HTT) are associated with an increased risk of lifetime depression. However, to what extent the variations in CAG repeat length in the other eight polyglutamine disease-associated genes (PDAGs) are associated with depression is still unknown. We determined the CAG repeat sizes of ATXN1, ATXN2, ATXN3, CACNA1A, ATXN7, TBP, ATN1 and AR in two well-characterized Dutch cohorts-the Netherlands Study of Depression and Anxiety and the Netherlands Study of Depression in Older Persons-including 2165 depressed and 1058 non-depressed individuals-aged 18-93 years. The association between PDAG CAG repeat size and the risk for depression was assessed via binary logistic regression. We found that the odds ratio (OR) for lifetime depression was significantly higher for individuals with >10, compared with subjects with

AB - Depression is one of the most prevalent and debilitating psychiatric disorders worldwide. Recently, we showed that both relatively short and relatively long cytosine-adenine-guanine (CAG) repeats in the huntingtin gene (HTT) are associated with an increased risk of lifetime depression. However, to what extent the variations in CAG repeat length in the other eight polyglutamine disease-associated genes (PDAGs) are associated with depression is still unknown. We determined the CAG repeat sizes of ATXN1, ATXN2, ATXN3, CACNA1A, ATXN7, TBP, ATN1 and AR in two well-characterized Dutch cohorts-the Netherlands Study of Depression and Anxiety and the Netherlands Study of Depression in Older Persons-including 2165 depressed and 1058 non-depressed individuals-aged 18-93 years. The association between PDAG CAG repeat size and the risk for depression was assessed via binary logistic regression. We found that the odds ratio (OR) for lifetime depression was significantly higher for individuals with >10, compared with subjects with

KW - DOMINANT CEREBELLAR-ATAXIA

KW - MACHADO-JOSEPH-DISEASE

KW - TATA-BINDING PROTEIN

KW - RNA-POLYMERASE-II

KW - SIMPLE SEQUENCE REPEATS

KW - SPINOCEREBELLAR ATAXIA

KW - TRINUCLEOTIDE REPEAT

KW - MAJOR DEPRESSION

KW - POLYGLUTAMINE EXPANSIONS

KW - CLINICAL-MANIFESTATION

U2 - 10.1038/tp.2017.116

DO - 10.1038/tp.2017.116

M3 - Article

VL - 7

JO - Translational Psychiatry

JF - Translational Psychiatry

SN - 2158-3188

M1 - e1143

ER -

ID: 43927277