Lactic acid bacteria secrete toll like receptor 2 stimulating and macrophage immunomodulating bioactive factorsRen, C., Cheng, L., Sun, Y., Zhang, Q., de Haan, B. J., Zhang, H., Faas, M. M. & de Vos, P., Mar-2020, In : Journal of Functional Foods. 66, 10 p., 103783.
Research output: Contribution to journal › Article › Academic › peer-review
Lactic acid bacteria (LAB) can support host health and crosstalks between ligands on bacterial cells and Toll-like receptors (TLR) are known as key inducers of these health effects. LAB-secreted bioactive factors also possess health-promoting properties but the underlying mechanisms remain to be identified. Here, we report that secreted factors of different LAB strains induce cytokine (IL-10 and TNF-alpha) production by THP1-differentiated human macrophages in a species- and strain-dependent manner. LAB-secreted products also drive immune-stimulating and anti-pathogenic M1-macrophage polarization. Moreover, bacterial supernatants induce species- and strain-dependent TLR2 activation. Several bacterial strains such as L. casei CCFM9 and L. brevis CCFM498 cannot activate TLR signaling, but their secreted products strongly activate TLR2. This indicates that LAB-secreted components may further boost the functional effects of bacterial strains. Our results confirm direct interactions of LAB-secreted components with TLRs, and provide novel insights in how LABs may provide immunemodulation.
|Number of pages||10|
|Journal||Journal of Functional Foods|
|Publication status||Published - Mar-2020|
- Immunomodulation, Lactic acid bacteria, Secreted bioactive factor, Toll-like receptor, LACTOBACILLUS-RHAMNOSUS, SUPERNATANT, INFLAMMATION, MICE, RNA