L1CAM expression in uterine carcinosarcoma is limited to the epithelial component and may be involved in epithelial-mesenchymal transition

Versluis, M., Plat, A., de Bruyn, M., Matias-Guiu, X., Trovic, J., Krakstad, C., Nijman, H. W., Bosse, T., de Bock, G. H. & Hollema, H., Nov-2018, In : Virchows Archiv : an International Journal of Pathology. 473, 5, p. 591-598 8 p.

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Uterine carcinosarcoma (UCS) has been proposed as a model for epithelial-mesenchymal transition (EMT), a process characterized by a functional change facilitating migration and metastasis in many types of cancer. L1CAM is an adhesion molecule that has been involved in EMT as a marker for mesenchymal phenotype. We examined expression of L1CAM in UCS in a cohort of 90 cases from four different centers. Slides were immunohistochemically stained for L1CAM and scored in four categories (0%, 50%). A score of more than 10% was considered positive for L1CAM. The median age at presentation was 68.6years, and half of the patients (53.3%) presented with FIGO stage 1 disease. Membranous L1CAM expression was positive in the epithelial component in 65.4% of cases. Remarkably, expression was negative in the mesenchymal component. In cases where both components were intermingled, expression limited to the epithelial component was confirmed by a double stain for L1CAM and keratin. Expression of L1CAM did not relate to overall or disease-free survival. Our findings suggest L1CAM is either not a marker for the mesenchymal phenotype in EMT, or UCS is not a good model for EMT.

Original languageEnglish
Pages (from-to)591-598
Number of pages8
JournalVirchows Archiv : an International Journal of Pathology
Issue number5
Early online date23-Aug-2018
Publication statusPublished - Nov-2018


  • Endometrial neoplasm, Neural cell adhesion molecule L1, L1CAM, Epithelial-mesenchymal transition, Histology, ENDOMETRIAL CANCER, ADHESION MOLECULE, UP-REGULATION, CARCINOMAS, SURVIVAL, PROGRESSION, PREDICTOR, EMT, PATHOLOGY, TUMORS

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