Publication

Key challenges in normal tissue complication probability model development and validation: towards a comprehensive strategy

Van den Bosch, L., Schuit, E., van der Laan, H. P., Reitsma, J. B., Moons, K. G. M., Steenbakkers, R. J. H. M., Hoebers, F. J. P., Langendijk, J. A. & van der Schaaf, A., Jul-2020, In : Radiotherapy and Oncology. 148, p. 151-156 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Van den Bosch, L., Schuit, E., van der Laan, H. P., Reitsma, J. B., Moons, K. G. M., Steenbakkers, R. J. H. M., ... van der Schaaf, A. (2020). Key challenges in normal tissue complication probability model development and validation: towards a comprehensive strategy. Radiotherapy and Oncology, 148, 151-156. https://doi.org/10.1016/j.radonc.2020.04.012

Author

Van den Bosch, Lisa ; Schuit, Ewoud ; van der Laan, Hans Paul ; Reitsma, Johannes B ; Moons, Karel G M ; Steenbakkers, Roel J H M ; Hoebers, Frank J P ; Langendijk, Johannes A ; van der Schaaf, Arjen. / Key challenges in normal tissue complication probability model development and validation : towards a comprehensive strategy. In: Radiotherapy and Oncology. 2020 ; Vol. 148. pp. 151-156.

Harvard

Van den Bosch, L, Schuit, E, van der Laan, HP, Reitsma, JB, Moons, KGM, Steenbakkers, RJHM, Hoebers, FJP, Langendijk, JA & van der Schaaf, A 2020, 'Key challenges in normal tissue complication probability model development and validation: towards a comprehensive strategy', Radiotherapy and Oncology, vol. 148, pp. 151-156. https://doi.org/10.1016/j.radonc.2020.04.012

Standard

Key challenges in normal tissue complication probability model development and validation : towards a comprehensive strategy. / Van den Bosch, Lisa; Schuit, Ewoud; van der Laan, Hans Paul; Reitsma, Johannes B; Moons, Karel G M; Steenbakkers, Roel J H M; Hoebers, Frank J P; Langendijk, Johannes A; van der Schaaf, Arjen.

In: Radiotherapy and Oncology, Vol. 148, 07.2020, p. 151-156.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Van den Bosch L, Schuit E, van der Laan HP, Reitsma JB, Moons KGM, Steenbakkers RJHM et al. Key challenges in normal tissue complication probability model development and validation: towards a comprehensive strategy. Radiotherapy and Oncology. 2020 Jul;148:151-156. https://doi.org/10.1016/j.radonc.2020.04.012


BibTeX

@article{8c0ce575d5604a0b983602187da3ee96,
title = "Key challenges in normal tissue complication probability model development and validation: towards a comprehensive strategy",
abstract = "Normal Tissue Complication Probability (NTCP) models can be used for treatment plan optimisation and patient selection for emerging treatment techniques. We discuss and suggest methodological approaches to address key challenges in NTCP model development and validation, including: missing data, non-linear response relationships, multicollinearity between predictors, overfitting, generalisability and the prediction of multiple complication grades at multiple time points. The methodological approaches chosen are aimed to improve the accuracy, transparency and robustness of future NTCP-models. We demonstrate our methodological approaches using clinical data.",
author = "{Van den Bosch}, Lisa and Ewoud Schuit and {van der Laan}, {Hans Paul} and Reitsma, {Johannes B} and Moons, {Karel G M} and Steenbakkers, {Roel J H M} and Hoebers, {Frank J P} and Langendijk, {Johannes A} and {van der Schaaf}, Arjen",
note = "Copyright {\circledC} 2020 The Authors. Published by Elsevier B.V. All rights reserved.",
year = "2020",
month = "7",
doi = "10.1016/j.radonc.2020.04.012",
language = "English",
volume = "148",
pages = "151--156",
journal = "Radiotherapy and Oncology",
issn = "0167-8140",
publisher = "ELSEVIER IRELAND LTD",

}

RIS

TY - JOUR

T1 - Key challenges in normal tissue complication probability model development and validation

T2 - towards a comprehensive strategy

AU - Van den Bosch, Lisa

AU - Schuit, Ewoud

AU - van der Laan, Hans Paul

AU - Reitsma, Johannes B

AU - Moons, Karel G M

AU - Steenbakkers, Roel J H M

AU - Hoebers, Frank J P

AU - Langendijk, Johannes A

AU - van der Schaaf, Arjen

N1 - Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

PY - 2020/7

Y1 - 2020/7

N2 - Normal Tissue Complication Probability (NTCP) models can be used for treatment plan optimisation and patient selection for emerging treatment techniques. We discuss and suggest methodological approaches to address key challenges in NTCP model development and validation, including: missing data, non-linear response relationships, multicollinearity between predictors, overfitting, generalisability and the prediction of multiple complication grades at multiple time points. The methodological approaches chosen are aimed to improve the accuracy, transparency and robustness of future NTCP-models. We demonstrate our methodological approaches using clinical data.

AB - Normal Tissue Complication Probability (NTCP) models can be used for treatment plan optimisation and patient selection for emerging treatment techniques. We discuss and suggest methodological approaches to address key challenges in NTCP model development and validation, including: missing data, non-linear response relationships, multicollinearity between predictors, overfitting, generalisability and the prediction of multiple complication grades at multiple time points. The methodological approaches chosen are aimed to improve the accuracy, transparency and robustness of future NTCP-models. We demonstrate our methodological approaches using clinical data.

U2 - 10.1016/j.radonc.2020.04.012

DO - 10.1016/j.radonc.2020.04.012

M3 - Article

C2 - 32388149

VL - 148

SP - 151

EP - 156

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

SN - 0167-8140

ER -

ID: 125536900