Publication

Isoprenoid biosynthesis in Archaea - Biochemical and evolutionary implications

Matsumi, R., Atomi, H., Driessen, A. J. M. & van der Oost, J., Jan-2011, In : Research in Microbiology. 162, 1, p. 39-52 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Copy link to clipboard

Documents

  • Isoprenoid biosynthesis in Archaea - Biochemical and evolutionary implications

    Final publisher's version, 404 KB, PDF document

    Request copy

DOI

Isoprenoids are indispensable for all types of cellular life in the Archaea, Bacteria, and Eucarya. These membrane-associated molecules are involved in a wide variety of vital biological functions, ranging from compartmentalization and stability, to protection and energy-transduction. In Archaea, isoprenoid compounds constitute the hydrophobic moiety of the typical ether-linked membrane lipids. With respect to stereochemistry and composition, these archaeal lipids are very different from the ester-linked, fatty acid-based phospholipids in bacterial and eukaryotic membranes. This review provides an update on isoprenoid biosynthesis pathways, with a focus on the archaeal enzymes. The black-and-white distribution of fundamentally distinct membrane lipids in Archaea on the one hand, and Bacteria and Eucarya on the other, has previously been used as a basis for hypothetical evolutionary scenarios, a selection of which will be discussed here. (C) 2010 Published by Elsevier Masson SAS on behalf of Institut Pasteur.

Original languageEnglish
Pages (from-to)39-52
Number of pages14
JournalResearch in Microbiology
Volume162
Issue number1
Publication statusPublished - Jan-2011

    Keywords

  • Archaea, Membrane, Lipids, Isoprenoids, Glycerol phosphate, Evolution, GERANYLGERANYL-DIPHOSPHATE SYNTHASE, ENANTIOMERIC GLYCEROPHOSPHATE BACKBONE, AEROBIC HYPERTHERMOPHILIC ARCHAEON, ISOPENTENYL PHOSPHATE KINASE, CHAIN-LENGTH DETERMINATION, BIPOLAR TETRAETHER LIPIDS, NON-MEVALONATE PATHWAY, AEROPYRUM-PERNIX K1, ETHER POLAR LIPIDS, THERMOACIDOPHILIC ARCHAEON

ID: 5313915