Isoprenoid biosynthesis in Archaea - Biochemical and evolutionary implicationsMatsumi, R., Atomi, H., Driessen, A. J. M. & van der Oost, J., Jan-2011, In : Research in Microbiology. 162, 1, p. 39-52 14 p.
Research output: Contribution to journal › Article › Academic › peer-review
Isoprenoids are indispensable for all types of cellular life in the Archaea, Bacteria, and Eucarya. These membrane-associated molecules are involved in a wide variety of vital biological functions, ranging from compartmentalization and stability, to protection and energy-transduction. In Archaea, isoprenoid compounds constitute the hydrophobic moiety of the typical ether-linked membrane lipids. With respect to stereochemistry and composition, these archaeal lipids are very different from the ester-linked, fatty acid-based phospholipids in bacterial and eukaryotic membranes. This review provides an update on isoprenoid biosynthesis pathways, with a focus on the archaeal enzymes. The black-and-white distribution of fundamentally distinct membrane lipids in Archaea on the one hand, and Bacteria and Eucarya on the other, has previously been used as a basis for hypothetical evolutionary scenarios, a selection of which will be discussed here. (C) 2010 Published by Elsevier Masson SAS on behalf of Institut Pasteur.
|Number of pages||14|
|Journal||Research in Microbiology|
|Publication status||Published - Jan-2011|
- Archaea, Membrane, Lipids, Isoprenoids, Glycerol phosphate, Evolution, GERANYLGERANYL-DIPHOSPHATE SYNTHASE, ENANTIOMERIC GLYCEROPHOSPHATE BACKBONE, AEROBIC HYPERTHERMOPHILIC ARCHAEON, ISOPENTENYL PHOSPHATE KINASE, CHAIN-LENGTH DETERMINATION, BIPOLAR TETRAETHER LIPIDS, NON-MEVALONATE PATHWAY, AEROPYRUM-PERNIX K1, ETHER POLAR LIPIDS, THERMOACIDOPHILIC ARCHAEON