Isocyanide-Based Multicomponent Reactions of Free Phenylboronic Acids

Neochoritis, C. G., Zarganes-Tzitzikas, T., Novotna, M., Mitrikova, T., Wang, Z., Kurpiewska, K., Kalinowska-Tluscik, J. & Domling, A., 22-Sep-2019, In : European Journal of Organic Chemistry. 2019, 35, p. 6132-6137 6 p.

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  • Isocyanide-Based Multicomponent Reactions of Free Phenylboronic Acids

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  • Constantinos G. Neochoritis
  • Tryfon Zarganes-Tzitzikas
  • Michaela Novotna
  • Tatiana Mitrikova
  • Zefeng Wang
  • Katarzyna Kurpiewska
  • Justyna Kalinowska-Tluscik
  • Alexander Domling

Boronic acids are amongst the most useful synthetic intermediates, frequently used by modern drug design. However, their access and fast synthesis of libraries are often problematic. We present a methodology on the synthesis of drug-like scaffolds via IMCRs with unprotected phenylboronic acids. To demonstrate an application of our approach, we also performed one-pot Suzuki couplings on the primary MCR scaffolds. Moreover, we performed a thorough data-mining of the Cambridge Structural Database, revealing interesting geometrical features.

Original languageEnglish
Pages (from-to)6132-6137
Number of pages6
JournalEuropean Journal of Organic Chemistry
Issue number35
Publication statusPublished - 22-Sep-2019


  • Multicomponent reactions, Boron, Ugi reaction, C-C coupling, Structure elucidation, BORONIC ACIDS, PYRAZINES, PLATFORM, ANALOGS

ID: 118401962