Isocyanide-Based Multicomponent Reactions of Free Phenylboronic AcidsNeochoritis, C. G., Zarganes-Tzitzikas, T., Novotna, M., Mitrikova, T., Wang, Z., Kurpiewska, K., Kalinowska-Tluscik, J. & Domling, A., 22-Sep-2019, In : European Journal of Organic Chemistry. 2019, 35, p. 6132-6137 6 p.
Research output: Contribution to journal › Article › Academic › peer-review
Boronic acids are amongst the most useful synthetic intermediates, frequently used by modern drug design. However, their access and fast synthesis of libraries are often problematic. We present a methodology on the synthesis of drug-like scaffolds via IMCRs with unprotected phenylboronic acids. To demonstrate an application of our approach, we also performed one-pot Suzuki couplings on the primary MCR scaffolds. Moreover, we performed a thorough data-mining of the Cambridge Structural Database, revealing interesting geometrical features.
|Number of pages||6|
|Journal||European Journal of Organic Chemistry|
|Publication status||Published - 22-Sep-2019|
- Multicomponent reactions, Boron, Ugi reaction, C-C coupling, Structure elucidation, BORONIC ACIDS, PYRAZINES, PLATFORM, ANALOGS