Publication

Isocaloric substitution of carbohydrates with protein: the association with weight change and mortality among patients with type 2 diabetes

Campmans-Kuijpers, M. J., Sluijs, I., Nöthlings, U., Freisling, H., Overvad, K., Weiderpass, E., Fagherazzi, G., Kühn, T., Katzke, V. A., Mattiello, A., Sonestedt, E., Masala, G., Agnoli, C., Tumino, R., Spijkerman, A. M. W., Barricarte, A., Ricceri, F., Chamosa, S., Johansson, I., Winkvist, A., Tjønneland, A., Sluik, D., Boeing, H. & Beulens, J. W. J., 18-Apr-2015, In : Cardiovascular Diabetology. 14, 10 p., 39.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Campmans-Kuijpers, M. J., Sluijs, I., Nöthlings, U., Freisling, H., Overvad, K., Weiderpass, E., Fagherazzi, G., Kühn, T., Katzke, V. A., Mattiello, A., Sonestedt, E., Masala, G., Agnoli, C., Tumino, R., Spijkerman, A. M. W., Barricarte, A., Ricceri, F., Chamosa, S., Johansson, I., ... Beulens, J. W. J. (2015). Isocaloric substitution of carbohydrates with protein: the association with weight change and mortality among patients with type 2 diabetes. Cardiovascular Diabetology, 14, [39]. https://doi.org/10.1186/s12933-015-0202-7

Author

Campmans-Kuijpers, Marjo Je ; Sluijs, Ivonne ; Nöthlings, Ute ; Freisling, Heinz ; Overvad, Kim ; Weiderpass, Elisabete ; Fagherazzi, Guy ; Kühn, Tilman ; Katzke, Verena A ; Mattiello, Amalia ; Sonestedt, Emily ; Masala, Giovanna ; Agnoli, Claudia ; Tumino, Rosario ; Spijkerman, Annemieke M W ; Barricarte, Aurelio ; Ricceri, Fulvio ; Chamosa, Saioa ; Johansson, Ingegerd ; Winkvist, Anna ; Tjønneland, Anne ; Sluik, Diewertje ; Boeing, Heiner ; Beulens, Joline W J. / Isocaloric substitution of carbohydrates with protein : the association with weight change and mortality among patients with type 2 diabetes. In: Cardiovascular Diabetology. 2015 ; Vol. 14.

Harvard

Campmans-Kuijpers, MJ, Sluijs, I, Nöthlings, U, Freisling, H, Overvad, K, Weiderpass, E, Fagherazzi, G, Kühn, T, Katzke, VA, Mattiello, A, Sonestedt, E, Masala, G, Agnoli, C, Tumino, R, Spijkerman, AMW, Barricarte, A, Ricceri, F, Chamosa, S, Johansson, I, Winkvist, A, Tjønneland, A, Sluik, D, Boeing, H & Beulens, JWJ 2015, 'Isocaloric substitution of carbohydrates with protein: the association with weight change and mortality among patients with type 2 diabetes', Cardiovascular Diabetology, vol. 14, 39. https://doi.org/10.1186/s12933-015-0202-7

Standard

Isocaloric substitution of carbohydrates with protein : the association with weight change and mortality among patients with type 2 diabetes. / Campmans-Kuijpers, Marjo Je; Sluijs, Ivonne; Nöthlings, Ute; Freisling, Heinz; Overvad, Kim; Weiderpass, Elisabete; Fagherazzi, Guy; Kühn, Tilman; Katzke, Verena A; Mattiello, Amalia; Sonestedt, Emily; Masala, Giovanna; Agnoli, Claudia; Tumino, Rosario; Spijkerman, Annemieke M W; Barricarte, Aurelio; Ricceri, Fulvio; Chamosa, Saioa; Johansson, Ingegerd; Winkvist, Anna; Tjønneland, Anne; Sluik, Diewertje; Boeing, Heiner; Beulens, Joline W J.

In: Cardiovascular Diabetology, Vol. 14, 39, 18.04.2015.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Campmans-Kuijpers MJ, Sluijs I, Nöthlings U, Freisling H, Overvad K, Weiderpass E et al. Isocaloric substitution of carbohydrates with protein: the association with weight change and mortality among patients with type 2 diabetes. Cardiovascular Diabetology. 2015 Apr 18;14. 39. https://doi.org/10.1186/s12933-015-0202-7


BibTeX

@article{c6aeda7a0f804b4598ca508a9a51d33b,
title = "Isocaloric substitution of carbohydrates with protein: the association with weight change and mortality among patients with type 2 diabetes",
abstract = "BACKGROUND: The health impact of dietary replacement of carbohydrates with protein for patients with type 2 diabetes is still debated. This study aimed to investigate the association between dietary substitution of carbohydrates with (animal and plant) protein and 5-year weight change, and all-cause and cardiovascular (CVD) mortality risk in patients with type 2 diabetes.METHODS: The study included 6,107 diabetes patients from 15 European cohorts. Patients with type 1 diabetes were excluded. At recruitment, validated country-specific food-frequency questionnaires were used to estimate dietary intake. Multivariable adjusted linear regression was used to examine the associations between dietary carbohydrate substitution with protein and 5-year weight change, and Cox regression to estimate hazard ratios (HRs) for (CVD) mortality.RESULTS: Annual weight loss of patients with type 2 diabetes was 0.17 (SD 1.24) kg. After a mean follow-up of 9.2 (SD 2.3)y, 787 (13%) participants had died, of which 266 (4%) deaths were due to CVD. Substitution of 10 gram dietary carbohydrate with total ({\ss} = 187 [75;299]g) and animal ({\ss} = 196 [137;254]g) protein was associated with mean 5-year weight gain. Substitution for plant protein was not significantly associated with weight change (β = 82 [-421;584]g). Substitution with plant protein was associated with lower all-cause mortality risk (HR = 0.79 [0.64;0.97]), whereas substitution with total or animal protein was not associated with (CVD) mortality risk.CONCLUSIONS: In diabetes patients, substitution with plant protein was beneficial with respect to weight change and all-cause mortality as opposed to substitution with animal protein. Therefore, future research is needed whether dietary guidelines should not actively promote substitution of carbohydrates by total protein, but rather focus on substitution of carbohydrates with plant protein.",
keywords = "Cohort Studies, Diabetes Mellitus, Type 2/diet therapy, Diet, Reducing/methods, Dietary Carbohydrates/administration & dosage, Dietary Proteins/administration & dosage, Energy Intake/physiology, Female, Follow-Up Studies, Humans, Male, Middle Aged, Mortality/trends, Plant Proteins, Dietary/administration & dosage, Prospective Studies, Risk Factors, Weight Gain/physiology, Weight Loss/physiology",
author = "Campmans-Kuijpers, {Marjo Je} and Ivonne Sluijs and Ute N{\"o}thlings and Heinz Freisling and Kim Overvad and Elisabete Weiderpass and Guy Fagherazzi and Tilman K{\"u}hn and Katzke, {Verena A} and Amalia Mattiello and Emily Sonestedt and Giovanna Masala and Claudia Agnoli and Rosario Tumino and Spijkerman, {Annemieke M W} and Aurelio Barricarte and Fulvio Ricceri and Saioa Chamosa and Ingegerd Johansson and Anna Winkvist and Anne Tj{\o}nneland and Diewertje Sluik and Heiner Boeing and Beulens, {Joline W J}",
year = "2015",
month = apr,
day = "18",
doi = "10.1186/s12933-015-0202-7",
language = "English",
volume = "14",
journal = "Cardiovascular Diabetology",
issn = "1475-2840",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Isocaloric substitution of carbohydrates with protein

T2 - the association with weight change and mortality among patients with type 2 diabetes

AU - Campmans-Kuijpers, Marjo Je

AU - Sluijs, Ivonne

AU - Nöthlings, Ute

AU - Freisling, Heinz

AU - Overvad, Kim

AU - Weiderpass, Elisabete

AU - Fagherazzi, Guy

AU - Kühn, Tilman

AU - Katzke, Verena A

AU - Mattiello, Amalia

AU - Sonestedt, Emily

AU - Masala, Giovanna

AU - Agnoli, Claudia

AU - Tumino, Rosario

AU - Spijkerman, Annemieke M W

AU - Barricarte, Aurelio

AU - Ricceri, Fulvio

AU - Chamosa, Saioa

AU - Johansson, Ingegerd

AU - Winkvist, Anna

AU - Tjønneland, Anne

AU - Sluik, Diewertje

AU - Boeing, Heiner

AU - Beulens, Joline W J

PY - 2015/4/18

Y1 - 2015/4/18

N2 - BACKGROUND: The health impact of dietary replacement of carbohydrates with protein for patients with type 2 diabetes is still debated. This study aimed to investigate the association between dietary substitution of carbohydrates with (animal and plant) protein and 5-year weight change, and all-cause and cardiovascular (CVD) mortality risk in patients with type 2 diabetes.METHODS: The study included 6,107 diabetes patients from 15 European cohorts. Patients with type 1 diabetes were excluded. At recruitment, validated country-specific food-frequency questionnaires were used to estimate dietary intake. Multivariable adjusted linear regression was used to examine the associations between dietary carbohydrate substitution with protein and 5-year weight change, and Cox regression to estimate hazard ratios (HRs) for (CVD) mortality.RESULTS: Annual weight loss of patients with type 2 diabetes was 0.17 (SD 1.24) kg. After a mean follow-up of 9.2 (SD 2.3)y, 787 (13%) participants had died, of which 266 (4%) deaths were due to CVD. Substitution of 10 gram dietary carbohydrate with total (ß = 187 [75;299]g) and animal (ß = 196 [137;254]g) protein was associated with mean 5-year weight gain. Substitution for plant protein was not significantly associated with weight change (β = 82 [-421;584]g). Substitution with plant protein was associated with lower all-cause mortality risk (HR = 0.79 [0.64;0.97]), whereas substitution with total or animal protein was not associated with (CVD) mortality risk.CONCLUSIONS: In diabetes patients, substitution with plant protein was beneficial with respect to weight change and all-cause mortality as opposed to substitution with animal protein. Therefore, future research is needed whether dietary guidelines should not actively promote substitution of carbohydrates by total protein, but rather focus on substitution of carbohydrates with plant protein.

AB - BACKGROUND: The health impact of dietary replacement of carbohydrates with protein for patients with type 2 diabetes is still debated. This study aimed to investigate the association between dietary substitution of carbohydrates with (animal and plant) protein and 5-year weight change, and all-cause and cardiovascular (CVD) mortality risk in patients with type 2 diabetes.METHODS: The study included 6,107 diabetes patients from 15 European cohorts. Patients with type 1 diabetes were excluded. At recruitment, validated country-specific food-frequency questionnaires were used to estimate dietary intake. Multivariable adjusted linear regression was used to examine the associations between dietary carbohydrate substitution with protein and 5-year weight change, and Cox regression to estimate hazard ratios (HRs) for (CVD) mortality.RESULTS: Annual weight loss of patients with type 2 diabetes was 0.17 (SD 1.24) kg. After a mean follow-up of 9.2 (SD 2.3)y, 787 (13%) participants had died, of which 266 (4%) deaths were due to CVD. Substitution of 10 gram dietary carbohydrate with total (ß = 187 [75;299]g) and animal (ß = 196 [137;254]g) protein was associated with mean 5-year weight gain. Substitution for plant protein was not significantly associated with weight change (β = 82 [-421;584]g). Substitution with plant protein was associated with lower all-cause mortality risk (HR = 0.79 [0.64;0.97]), whereas substitution with total or animal protein was not associated with (CVD) mortality risk.CONCLUSIONS: In diabetes patients, substitution with plant protein was beneficial with respect to weight change and all-cause mortality as opposed to substitution with animal protein. Therefore, future research is needed whether dietary guidelines should not actively promote substitution of carbohydrates by total protein, but rather focus on substitution of carbohydrates with plant protein.

KW - Cohort Studies

KW - Diabetes Mellitus, Type 2/diet therapy

KW - Diet, Reducing/methods

KW - Dietary Carbohydrates/administration & dosage

KW - Dietary Proteins/administration & dosage

KW - Energy Intake/physiology

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Middle Aged

KW - Mortality/trends

KW - Plant Proteins, Dietary/administration & dosage

KW - Prospective Studies

KW - Risk Factors

KW - Weight Gain/physiology

KW - Weight Loss/physiology

U2 - 10.1186/s12933-015-0202-7

DO - 10.1186/s12933-015-0202-7

M3 - Article

C2 - 25896172

VL - 14

JO - Cardiovascular Diabetology

JF - Cardiovascular Diabetology

SN - 1475-2840

M1 - 39

ER -

ID: 127978254