Publication

Is human papillomavirus involved in laryngeal neuroendocrine carcinoma?

Halmos, G. B., van der Laan, T. P., van Hemel, B. M., Dikkers, F. G., Slagter-Menkema, L., van der Laan, B. F. A. M. & Schuuring, E., Feb-2013, In : European Archives of Oto-Rhino-Laryngology. 270, 2, p. 719-725 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Halmos, G. B., van der Laan, T. P., van Hemel, B. M., Dikkers, F. G., Slagter-Menkema, L., van der Laan, B. F. A. M., & Schuuring, E. (2013). Is human papillomavirus involved in laryngeal neuroendocrine carcinoma? European Archives of Oto-Rhino-Laryngology, 270(2), 719-725. https://doi.org/10.1007/s00405-012-2075-7

Author

Halmos, Gyorgy B ; van der Laan, Tom P ; van Hemel, Bettien M ; Dikkers, Frederik G ; Slagter-Menkema, Lorian ; van der Laan, Bernard F A M ; Schuuring, Ed. / Is human papillomavirus involved in laryngeal neuroendocrine carcinoma?. In: European Archives of Oto-Rhino-Laryngology. 2013 ; Vol. 270, No. 2. pp. 719-725.

Harvard

Halmos, GB, van der Laan, TP, van Hemel, BM, Dikkers, FG, Slagter-Menkema, L, van der Laan, BFAM & Schuuring, E 2013, 'Is human papillomavirus involved in laryngeal neuroendocrine carcinoma?', European Archives of Oto-Rhino-Laryngology, vol. 270, no. 2, pp. 719-725. https://doi.org/10.1007/s00405-012-2075-7

Standard

Is human papillomavirus involved in laryngeal neuroendocrine carcinoma? / Halmos, Gyorgy B; van der Laan, Tom P; van Hemel, Bettien M; Dikkers, Frederik G; Slagter-Menkema, Lorian; van der Laan, Bernard F A M; Schuuring, Ed.

In: European Archives of Oto-Rhino-Laryngology, Vol. 270, No. 2, 02.2013, p. 719-725.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Halmos GB, van der Laan TP, van Hemel BM, Dikkers FG, Slagter-Menkema L, van der Laan BFAM et al. Is human papillomavirus involved in laryngeal neuroendocrine carcinoma? European Archives of Oto-Rhino-Laryngology. 2013 Feb;270(2):719-725. https://doi.org/10.1007/s00405-012-2075-7


BibTeX

@article{7bbc2b910e5e4dcd89a9eb8341a10945,
title = "Is human papillomavirus involved in laryngeal neuroendocrine carcinoma?",
abstract = "The purpose of this study was to detect human papillomavirus (HPV) infection in laryngeal neuroendocrine carcinoma (LNEC) and to explore the possible relationship between HPV-induced malignant transformation and prognosis in LNEC. Ten cases of LNEC from a tertiary referral hospital were retrospectively analyzed. Clinical data were subtracted from patients' files. Pretreatment biopsy material was tested for the presence of HPV6, 11, 16, and 18 using a PCR-based detection method. Immunohistochemical staining was performed for Ki-67, p16(INK4A), and p53 expression. All cases were negative for the low-risk HPV types HPV6 and HPV11 that are associated with laryngeal papillomatosis. High-risk HPV was detected in two cases; an atypical carcinoid was positive for HPV16 and a large-cell neuroendocrine carcinoma for HPV18. Both HPV-positive tumors had a high Ki-67 labeling index. Two of the four cases with a good response to therapy were hrHPV-positive (both HPV DNA positive) compared with none of the five poor responders. Our findings show that HPV may play a role in the pathogenesis of LNEC. The relationship between HPV, improved prognosis and good response to therapy for squamous cell carcinoma of the head and neck may also be true for a subset of LNEC.",
keywords = "Aged, Carcinoma, Neuroendocrine, DNA, Viral, Female, Human papillomavirus 16, Human papillomavirus 18, Humans, Ki-67 Antigen, Laryngeal Neoplasms, Male, Middle Aged, Prognosis, Tumor Suppressor Protein p53",
author = "Halmos, {Gyorgy B} and {van der Laan}, {Tom P} and {van Hemel}, {Bettien M} and Dikkers, {Frederik G} and Lorian Slagter-Menkema and {van der Laan}, {Bernard F A M} and Ed Schuuring",
year = "2013",
month = "2",
doi = "10.1007/s00405-012-2075-7",
language = "English",
volume = "270",
pages = "719--725",
journal = "European Archives of Oto-Rhino-Laryngology",
issn = "0937-4477",
publisher = "SPRINGER",
number = "2",

}

RIS

TY - JOUR

T1 - Is human papillomavirus involved in laryngeal neuroendocrine carcinoma?

AU - Halmos, Gyorgy B

AU - van der Laan, Tom P

AU - van Hemel, Bettien M

AU - Dikkers, Frederik G

AU - Slagter-Menkema, Lorian

AU - van der Laan, Bernard F A M

AU - Schuuring, Ed

PY - 2013/2

Y1 - 2013/2

N2 - The purpose of this study was to detect human papillomavirus (HPV) infection in laryngeal neuroendocrine carcinoma (LNEC) and to explore the possible relationship between HPV-induced malignant transformation and prognosis in LNEC. Ten cases of LNEC from a tertiary referral hospital were retrospectively analyzed. Clinical data were subtracted from patients' files. Pretreatment biopsy material was tested for the presence of HPV6, 11, 16, and 18 using a PCR-based detection method. Immunohistochemical staining was performed for Ki-67, p16(INK4A), and p53 expression. All cases were negative for the low-risk HPV types HPV6 and HPV11 that are associated with laryngeal papillomatosis. High-risk HPV was detected in two cases; an atypical carcinoid was positive for HPV16 and a large-cell neuroendocrine carcinoma for HPV18. Both HPV-positive tumors had a high Ki-67 labeling index. Two of the four cases with a good response to therapy were hrHPV-positive (both HPV DNA positive) compared with none of the five poor responders. Our findings show that HPV may play a role in the pathogenesis of LNEC. The relationship between HPV, improved prognosis and good response to therapy for squamous cell carcinoma of the head and neck may also be true for a subset of LNEC.

AB - The purpose of this study was to detect human papillomavirus (HPV) infection in laryngeal neuroendocrine carcinoma (LNEC) and to explore the possible relationship between HPV-induced malignant transformation and prognosis in LNEC. Ten cases of LNEC from a tertiary referral hospital were retrospectively analyzed. Clinical data were subtracted from patients' files. Pretreatment biopsy material was tested for the presence of HPV6, 11, 16, and 18 using a PCR-based detection method. Immunohistochemical staining was performed for Ki-67, p16(INK4A), and p53 expression. All cases were negative for the low-risk HPV types HPV6 and HPV11 that are associated with laryngeal papillomatosis. High-risk HPV was detected in two cases; an atypical carcinoid was positive for HPV16 and a large-cell neuroendocrine carcinoma for HPV18. Both HPV-positive tumors had a high Ki-67 labeling index. Two of the four cases with a good response to therapy were hrHPV-positive (both HPV DNA positive) compared with none of the five poor responders. Our findings show that HPV may play a role in the pathogenesis of LNEC. The relationship between HPV, improved prognosis and good response to therapy for squamous cell carcinoma of the head and neck may also be true for a subset of LNEC.

KW - Aged

KW - Carcinoma, Neuroendocrine

KW - DNA, Viral

KW - Female

KW - Human papillomavirus 16

KW - Human papillomavirus 18

KW - Humans

KW - Ki-67 Antigen

KW - Laryngeal Neoplasms

KW - Male

KW - Middle Aged

KW - Prognosis

KW - Tumor Suppressor Protein p53

U2 - 10.1007/s00405-012-2075-7

DO - 10.1007/s00405-012-2075-7

M3 - Article

VL - 270

SP - 719

EP - 725

JO - European Archives of Oto-Rhino-Laryngology

JF - European Archives of Oto-Rhino-Laryngology

SN - 0937-4477

IS - 2

ER -

ID: 5778427