Is Fatigue a Disease-Specific or Generic Symptom in Chronic Medical Conditions?Menting, J., Tack, C. J., Bleijenberg, G., Donders, R., Droogleever Fortuyn, H. A., Fransen, J., Goedendorp, M. M., Kalkman, J. S., Strik-Albers, R., van Alfen, N., van der Werf, S. P., Voermans, N. C., van Engelen, B. G. & Knoop, H., Jun-2018, In : Health Psychology. 37, 6, p. 530-543 14 p.
Research output: Contribution to journal › Article › Academic › peer-review
OBJECTIVE: Severe fatigue is highly prevalent in various chronic diseases. Disease-specific fatigue models have been developed, but it is possible that fatigue-related factors in these models are similar across diseases. The purpose of the current study was to determine the amount of variance in fatigue severity explained by: (a) the specific disease, (b) factors associated with fatigue across different chronic diseases (transdiagnostic factors), and (c) the interactions between these factors and specific diseases.
METHOD: Data from 15 studies that included 1696 patients with common chronic diseases and disorders that cause long-term disabilities were analyzed. Linear regression analysis with the generalized least-squares technique was used to determine fatigue-related factors associated with fatigue severity, that is, demographic variables, health-related symptoms and psychosocial variables.
RESULTS: Type of chronic disease explained 11% of the variance noted in fatigue severity. The explained variance increased to 55% when the transdiagnostic factors were added to the model. These factors were female sex, age, motivational and concentration problems, pain, sleep disturbances, physical functioning, reduced activity and lower self-efficacy concerning fatigue. The predicted variance increased to 61% when interaction terms were added. Analysis of the interactions revealed that the relationship between fatigue severity and relevant predictors mainly differed in strength, not in direction.
CONCLUSIONS: Fatigue severity can largely be explained by transdiagnostic factors; the associations vary between chronic diseases in strength and significance. This suggests that severely fatigued patients with different chronic diseases can probably benefit from a transdiagnostic fatigue-approach which focuses on individual patient needs rather than a specific disease. (PsycINFO Database Record
|Number of pages||14|
|Publication status||Published - Jun-2018|
- chronic disease, fatigue, health-related factors, psychosocial factors, transdiagnostic approach, RANDOMIZED CONTROLLED-TRIAL, COGNITIVE-BEHAVIORAL THERAPY, MULTIPLE-SCLEROSIS FATIGUE, RHEUMATOID-ARTHRITIS, HIGHLY PREVALENT, MODEL, PREDICTORS, DISABILITY, DISORDERS, STROKE