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Is aortoiliac calcification linked to colorectal anastomotic leakage? A case-control study

Boersema, G. S. A., Vakalopoulos, K. A., Kock, M. C. J. M., van Ooijen, P. M. A., Havenga, K., Kleinrensink, G. J., Jeekel, J. & Lange, J. F., Jan-2016, In : International Journal of Surgery. 25, p. 123-127 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Background: Anastomotic leakage in bowel surgery remains a devastating complication. Various risk factors have been uncovered, however, high anastomotic leakage rates are still being reported. This study describes the use of calcification markers of the central abdominal arteries as a prognostic factor for colorectal anastomotic leakage.

Methods: This case-control study includes clinical data from three different hospitals. Calcium volume and calcium score of the aortoiliac tract were determined by CT-scan analysis. Cases were all patients with anastomotic leakage after a left-sided anastomosis (n = 30). Three controls were randomly matched for each case. Only patients with a contrast-enhanced pre-operative CT-scan were included.

Results: The measurements of the calcium score and calcium volume of the different trajectories showed that there was one significant difference with regard to the right external iliac artery. Multiple regression analysis showed a significant different negative odds ratio of the presence of calcium in the right external iliac artery.

Conclusion: This study demonstrates that calcium volume and calcium score of the aortoiliac trajectory does not correlate with the risk of colorectal anastomotic leakage after a left-sided anastomosis. (C) 2015 IJS Publishing Group Limited. Published by Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)123-127
Number of pages5
JournalInternational Journal of Surgery
Volume25
Publication statusPublished - Jan-2016

    Keywords

  • Calcium volume, Calcium score, Anastomotic leakage, Prognostic factor, Colorectal surgery, ISCHEMIA-REPERFUSION INJURY, TOTAL MESORECTAL EXCISION, LOW ANTERIOR RESECTION, RISK-FACTORS, RECTAL-CANCER, COLONIC ANASTOMOSES, OXYGEN-TENSION, SURGERY, DISEASE, HYPERCHOLESTEROLEMIA

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