Publication

Intrinsic mesocorticolimbic connectivity is negatively associated with social amotivation in people with schizophrenia

Xu, P., Klaasen, N. G., Opmeer, E. M., Pijnenborg, G. H. M., van Tol, M-J., Liemburg, E. J. & Aleman, A., Jun-2019, In : Schizophrenia Research. 208, p. 353-359 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Xu, P., Klaasen, N. G., Opmeer, E. M., Pijnenborg, G. H. M., van Tol, M-J., Liemburg, E. J., & Aleman, A. (2019). Intrinsic mesocorticolimbic connectivity is negatively associated with social amotivation in people with schizophrenia. Schizophrenia Research, 208, 353-359. https://doi.org/10.1016/j.schres.2019.01.023

Author

Xu, Pengfei ; Klaasen, Nicky G ; Opmeer, Esther M ; Pijnenborg, Gerdina H M ; van Tol, Marie-José ; Liemburg, Edith J ; Aleman, André. / Intrinsic mesocorticolimbic connectivity is negatively associated with social amotivation in people with schizophrenia. In: Schizophrenia Research. 2019 ; Vol. 208. pp. 353-359.

Harvard

Xu, P, Klaasen, NG, Opmeer, EM, Pijnenborg, GHM, van Tol, M-J, Liemburg, EJ & Aleman, A 2019, 'Intrinsic mesocorticolimbic connectivity is negatively associated with social amotivation in people with schizophrenia' Schizophrenia Research, vol. 208, pp. 353-359. https://doi.org/10.1016/j.schres.2019.01.023

Standard

Intrinsic mesocorticolimbic connectivity is negatively associated with social amotivation in people with schizophrenia. / Xu, Pengfei; Klaasen, Nicky G; Opmeer, Esther M; Pijnenborg, Gerdina H M; van Tol, Marie-José; Liemburg, Edith J; Aleman, André.

In: Schizophrenia Research, Vol. 208, 06.2019, p. 353-359.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Xu P, Klaasen NG, Opmeer EM, Pijnenborg GHM, van Tol M-J, Liemburg EJ et al. Intrinsic mesocorticolimbic connectivity is negatively associated with social amotivation in people with schizophrenia. Schizophrenia Research. 2019 Jun;208:353-359. https://doi.org/10.1016/j.schres.2019.01.023


BibTeX

@article{79be15bcc9e149a0b75f4bc547853a54,
title = "Intrinsic mesocorticolimbic connectivity is negatively associated with social amotivation in people with schizophrenia",
abstract = "Background: Social amotivation is a core element of the negative symptoms of schizophrenia. However, it is still largely unknown which neural substrates underpin social amotivation in people with schizophrenia, though deficiencies in the mesocorticolimbic dopamine system have been proposed.Methods: We examined the association between social amotivation and substantia nigra/ventral tegmental area-seeded intrinsic connectivity in 84 people with schizophrenia using resting state functional magnetic resonance imaging.Results: Spontaneous fluctuations of midbrain dopaminergic regions were positively associated with striatal and prefrontal fluctuations in people with schizophrenia. Most importantly, social amotivation was negatively associated with functional connectivity between the midbrain's substantia nigra/ventral tegmental area and medial-and lateral prefrontal cortex, the temporoparietal junction, and dorsal and ventral striatum. These associations were observed independently of depressive and positive symptoms.Conclusions: Our findings suggest that social amotivation in people with schizophrenia is associated with altered intrinsic connectivity of mesocorticolimbic pathways linked to cognitive control and reward processing. Dysconnectivity of dopaminergic neuronal ensembles that are fundamental to approach behavior and motivation may help explain the lack of initiative social behavior in people with social amotivation. (C) 2019 Elsevier B.V. All rights reserved.",
keywords = "Social amotivation, Resting state functional connectivity, Schizophrenia, Ventral tegmental area, Mesocorticolimbic pathways, FUNCTIONAL CONNECTIVITY, COGNITIVE CONTROL, DOPAMINE, SYMPTOMS, APATHY, DEFICITS, ACTIVATION, PREDICTION, MOTIVATION, NETWORKS",
author = "Pengfei Xu and Klaasen, {Nicky G} and Opmeer, {Esther M} and Pijnenborg, {Gerdina H M} and {van Tol}, Marie-Jos{\'e} and Liemburg, {Edith J} and Andr{\'e} Aleman",
note = "Copyright {\circledC} 2019. Published by Elsevier B.V.",
year = "2019",
month = "6",
doi = "10.1016/j.schres.2019.01.023",
language = "English",
volume = "208",
pages = "353--359",
journal = "Schizophrenia Research",
issn = "0920-9964",
publisher = "ELSEVIER SCIENCE BV",

}

RIS

TY - JOUR

T1 - Intrinsic mesocorticolimbic connectivity is negatively associated with social amotivation in people with schizophrenia

AU - Xu, Pengfei

AU - Klaasen, Nicky G

AU - Opmeer, Esther M

AU - Pijnenborg, Gerdina H M

AU - van Tol, Marie-José

AU - Liemburg, Edith J

AU - Aleman, André

N1 - Copyright © 2019. Published by Elsevier B.V.

PY - 2019/6

Y1 - 2019/6

N2 - Background: Social amotivation is a core element of the negative symptoms of schizophrenia. However, it is still largely unknown which neural substrates underpin social amotivation in people with schizophrenia, though deficiencies in the mesocorticolimbic dopamine system have been proposed.Methods: We examined the association between social amotivation and substantia nigra/ventral tegmental area-seeded intrinsic connectivity in 84 people with schizophrenia using resting state functional magnetic resonance imaging.Results: Spontaneous fluctuations of midbrain dopaminergic regions were positively associated with striatal and prefrontal fluctuations in people with schizophrenia. Most importantly, social amotivation was negatively associated with functional connectivity between the midbrain's substantia nigra/ventral tegmental area and medial-and lateral prefrontal cortex, the temporoparietal junction, and dorsal and ventral striatum. These associations were observed independently of depressive and positive symptoms.Conclusions: Our findings suggest that social amotivation in people with schizophrenia is associated with altered intrinsic connectivity of mesocorticolimbic pathways linked to cognitive control and reward processing. Dysconnectivity of dopaminergic neuronal ensembles that are fundamental to approach behavior and motivation may help explain the lack of initiative social behavior in people with social amotivation. (C) 2019 Elsevier B.V. All rights reserved.

AB - Background: Social amotivation is a core element of the negative symptoms of schizophrenia. However, it is still largely unknown which neural substrates underpin social amotivation in people with schizophrenia, though deficiencies in the mesocorticolimbic dopamine system have been proposed.Methods: We examined the association between social amotivation and substantia nigra/ventral tegmental area-seeded intrinsic connectivity in 84 people with schizophrenia using resting state functional magnetic resonance imaging.Results: Spontaneous fluctuations of midbrain dopaminergic regions were positively associated with striatal and prefrontal fluctuations in people with schizophrenia. Most importantly, social amotivation was negatively associated with functional connectivity between the midbrain's substantia nigra/ventral tegmental area and medial-and lateral prefrontal cortex, the temporoparietal junction, and dorsal and ventral striatum. These associations were observed independently of depressive and positive symptoms.Conclusions: Our findings suggest that social amotivation in people with schizophrenia is associated with altered intrinsic connectivity of mesocorticolimbic pathways linked to cognitive control and reward processing. Dysconnectivity of dopaminergic neuronal ensembles that are fundamental to approach behavior and motivation may help explain the lack of initiative social behavior in people with social amotivation. (C) 2019 Elsevier B.V. All rights reserved.

KW - Social amotivation

KW - Resting state functional connectivity

KW - Schizophrenia

KW - Ventral tegmental area

KW - Mesocorticolimbic pathways

KW - FUNCTIONAL CONNECTIVITY

KW - COGNITIVE CONTROL

KW - DOPAMINE

KW - SYMPTOMS

KW - APATHY

KW - DEFICITS

KW - ACTIVATION

KW - PREDICTION

KW - MOTIVATION

KW - NETWORKS

U2 - 10.1016/j.schres.2019.01.023

DO - 10.1016/j.schres.2019.01.023

M3 - Article

VL - 208

SP - 353

EP - 359

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

ER -

ID: 83121450