Publication

Intrastriatal gradient analyses of 18F-FDOPA PET scans for differentiation of Parkinsonian disorders

Stormezand, G. N., Chaves, L. T., Garcia, D. V., Doorduin, J., De Jong, B. M., Leenders, K. L., Kremer, B. P. H. & Dierckx, R. A. J. O., 2020, In : NeuroImage. Clinical. 25, 5 p., 102161.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Stormezand, G. N., Chaves, L. T., Garcia, D. V., Doorduin, J., De Jong, B. M., Leenders, K. L., ... Dierckx, R. A. J. O. (2020). Intrastriatal gradient analyses of 18F-FDOPA PET scans for differentiation of Parkinsonian disorders. NeuroImage. Clinical, 25, [102161]. https://doi.org/10.1016/j.nicl.2019.102161

Author

Stormezand, Gilles N. ; Chaves, Lumi T. ; Garcia, David Vallez ; Doorduin, Janine ; De Jong, Bauke M. ; Leenders, Klaus L. ; Kremer, Berry P. H. ; Dierckx, Rudi A. J. O. / Intrastriatal gradient analyses of 18F-FDOPA PET scans for differentiation of Parkinsonian disorders. In: NeuroImage. Clinical. 2020 ; Vol. 25.

Harvard

Stormezand, GN, Chaves, LT, Garcia, DV, Doorduin, J, De Jong, BM, Leenders, KL, Kremer, BPH & Dierckx, RAJO 2020, 'Intrastriatal gradient analyses of 18F-FDOPA PET scans for differentiation of Parkinsonian disorders', NeuroImage. Clinical, vol. 25, 102161. https://doi.org/10.1016/j.nicl.2019.102161

Standard

Intrastriatal gradient analyses of 18F-FDOPA PET scans for differentiation of Parkinsonian disorders. / Stormezand, Gilles N.; Chaves, Lumi T.; Garcia, David Vallez; Doorduin, Janine; De Jong, Bauke M.; Leenders, Klaus L.; Kremer, Berry P. H.; Dierckx, Rudi A. J. O.

In: NeuroImage. Clinical, Vol. 25, 102161, 2020.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Stormezand GN, Chaves LT, Garcia DV, Doorduin J, De Jong BM, Leenders KL et al. Intrastriatal gradient analyses of 18F-FDOPA PET scans for differentiation of Parkinsonian disorders. NeuroImage. Clinical. 2020;25. 102161. https://doi.org/10.1016/j.nicl.2019.102161


BibTeX

@article{55349a864ce0469393a45681da2900db,
title = "Intrastriatal gradient analyses of 18F-FDOPA PET scans for differentiation of Parkinsonian disorders",
abstract = "Aim: L -3,4-dihydroxy-6-18F-fluorophenylalanine (18F-DOPA PET may be used to distinguish subjects with Parkinsonism from those with symptoms not originating from impaired dopaminergic transmission. However, it is not routinely utilized to discriminate Idiopathic Parkinson's disease (IPD) from Atypical Parkinsonian Disorders (APD). We investigated the potential of FDOPA PET to discriminate between IPD and APD, with a focus on the anterior-to-posterior decline in he striatum, considered to be more specific for IPD.Materials and methods: 18F-DOPA PET data from a total of 58 subjects were retrospectively analyzed. 28 subjects had idiopathic Parkinson's disease (14 male, 14 female; age at scan 61 +- 11,5), 13 atypical Parkinsonian disease (7 male, 6 females; age at scan: 69,6 +- 6,4) and 17 were controls (6 male, 11 female; age at scan 65,3 + -8,6). Regional striatal-to-occipital ratio's (RSOR's) were calculated, as well as multiple in-line VOI's from the caudate nucleus to the posterior part of the putamen. The linearity of anteroposterior decline was determined by a linear regression fit and associated R squared values. ROC curves were calculated to assess the diagnostic performance of these measurements. Data contralateral to the clinically most affected side were used for analysis.Results: ROC curve analysis for differentiation between controls and Parkinsonism patients showed the highest AUC for the caudate nucleus-to-posterior putamen ratio (AUC = 0.930; p <0.00) and for the R squared value for the linear regression fit (AUC = 0.948; p = 0.006). For discrimating IPD from APD, the highest AUC was found for the caudate nucleus-to-anterior putamen ratio (0.824; p <0.001)Conclusions: Subregional analysis of the striatum in F-DOPA PET scans may provide additional diagnostic information in patients screened for a presynaptic dopaminergic deficit. A more linear decrease from the head of the caudate nucleus to the posterior putamen was present in patients with IPD, although this feature did not have additional diagnostic value over the RSOR analysis.",
keywords = "PET, Parkinson's disease, Atypical Parkinsonism, MULTIPLE SYSTEM ATROPHY, CLINICAL-DIAGNOSIS, DISEASE, FDOPA",
author = "Stormezand, {Gilles N.} and Chaves, {Lumi T.} and Garcia, {David Vallez} and Janine Doorduin and {De Jong}, {Bauke M.} and Leenders, {Klaus L.} and Kremer, {Berry P. H.} and Dierckx, {Rudi A. J. O.}",
note = "Copyright {\circledC} 2020 The Author(s). Published by Elsevier Inc. All rights reserved.",
year = "2020",
doi = "10.1016/j.nicl.2019.102161",
language = "English",
volume = "25",
journal = "NeuroImage. Clinical",
issn = "2213-1582",
publisher = "ELSEVIER SCI LTD",

}

RIS

TY - JOUR

T1 - Intrastriatal gradient analyses of 18F-FDOPA PET scans for differentiation of Parkinsonian disorders

AU - Stormezand, Gilles N.

AU - Chaves, Lumi T.

AU - Garcia, David Vallez

AU - Doorduin, Janine

AU - De Jong, Bauke M.

AU - Leenders, Klaus L.

AU - Kremer, Berry P. H.

AU - Dierckx, Rudi A. J. O.

N1 - Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.

PY - 2020

Y1 - 2020

N2 - Aim: L -3,4-dihydroxy-6-18F-fluorophenylalanine (18F-DOPA PET may be used to distinguish subjects with Parkinsonism from those with symptoms not originating from impaired dopaminergic transmission. However, it is not routinely utilized to discriminate Idiopathic Parkinson's disease (IPD) from Atypical Parkinsonian Disorders (APD). We investigated the potential of FDOPA PET to discriminate between IPD and APD, with a focus on the anterior-to-posterior decline in he striatum, considered to be more specific for IPD.Materials and methods: 18F-DOPA PET data from a total of 58 subjects were retrospectively analyzed. 28 subjects had idiopathic Parkinson's disease (14 male, 14 female; age at scan 61 +- 11,5), 13 atypical Parkinsonian disease (7 male, 6 females; age at scan: 69,6 +- 6,4) and 17 were controls (6 male, 11 female; age at scan 65,3 + -8,6). Regional striatal-to-occipital ratio's (RSOR's) were calculated, as well as multiple in-line VOI's from the caudate nucleus to the posterior part of the putamen. The linearity of anteroposterior decline was determined by a linear regression fit and associated R squared values. ROC curves were calculated to assess the diagnostic performance of these measurements. Data contralateral to the clinically most affected side were used for analysis.Results: ROC curve analysis for differentiation between controls and Parkinsonism patients showed the highest AUC for the caudate nucleus-to-posterior putamen ratio (AUC = 0.930; p <0.00) and for the R squared value for the linear regression fit (AUC = 0.948; p = 0.006). For discrimating IPD from APD, the highest AUC was found for the caudate nucleus-to-anterior putamen ratio (0.824; p <0.001)Conclusions: Subregional analysis of the striatum in F-DOPA PET scans may provide additional diagnostic information in patients screened for a presynaptic dopaminergic deficit. A more linear decrease from the head of the caudate nucleus to the posterior putamen was present in patients with IPD, although this feature did not have additional diagnostic value over the RSOR analysis.

AB - Aim: L -3,4-dihydroxy-6-18F-fluorophenylalanine (18F-DOPA PET may be used to distinguish subjects with Parkinsonism from those with symptoms not originating from impaired dopaminergic transmission. However, it is not routinely utilized to discriminate Idiopathic Parkinson's disease (IPD) from Atypical Parkinsonian Disorders (APD). We investigated the potential of FDOPA PET to discriminate between IPD and APD, with a focus on the anterior-to-posterior decline in he striatum, considered to be more specific for IPD.Materials and methods: 18F-DOPA PET data from a total of 58 subjects were retrospectively analyzed. 28 subjects had idiopathic Parkinson's disease (14 male, 14 female; age at scan 61 +- 11,5), 13 atypical Parkinsonian disease (7 male, 6 females; age at scan: 69,6 +- 6,4) and 17 were controls (6 male, 11 female; age at scan 65,3 + -8,6). Regional striatal-to-occipital ratio's (RSOR's) were calculated, as well as multiple in-line VOI's from the caudate nucleus to the posterior part of the putamen. The linearity of anteroposterior decline was determined by a linear regression fit and associated R squared values. ROC curves were calculated to assess the diagnostic performance of these measurements. Data contralateral to the clinically most affected side were used for analysis.Results: ROC curve analysis for differentiation between controls and Parkinsonism patients showed the highest AUC for the caudate nucleus-to-posterior putamen ratio (AUC = 0.930; p <0.00) and for the R squared value for the linear regression fit (AUC = 0.948; p = 0.006). For discrimating IPD from APD, the highest AUC was found for the caudate nucleus-to-anterior putamen ratio (0.824; p <0.001)Conclusions: Subregional analysis of the striatum in F-DOPA PET scans may provide additional diagnostic information in patients screened for a presynaptic dopaminergic deficit. A more linear decrease from the head of the caudate nucleus to the posterior putamen was present in patients with IPD, although this feature did not have additional diagnostic value over the RSOR analysis.

KW - PET

KW - Parkinson's disease

KW - Atypical Parkinsonism

KW - MULTIPLE SYSTEM ATROPHY

KW - CLINICAL-DIAGNOSIS

KW - DISEASE

KW - FDOPA

U2 - 10.1016/j.nicl.2019.102161

DO - 10.1016/j.nicl.2019.102161

M3 - Article

VL - 25

JO - NeuroImage. Clinical

JF - NeuroImage. Clinical

SN - 2213-1582

M1 - 102161

ER -

ID: 112966697