Publication

Intraoperative cell salvage during cardiac surgery is associated with reduced postoperative lung injury

Engels, G. E., van Klarenbosch, J., Gu, Y. J., van Oeveren, W. & de Vries, A. J., Mar-2016, In : Interactive Cardiovascular and Thoracic Surgery. 22, 3, p. 298-304 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Engels, G. E., van Klarenbosch, J., Gu, Y. J., van Oeveren, W., & de Vries, A. J. (2016). Intraoperative cell salvage during cardiac surgery is associated with reduced postoperative lung injury. Interactive Cardiovascular and Thoracic Surgery, 22(3), 298-304. https://doi.org/10.1093/icvts/ivv355

Author

Engels, Gerwin E. ; van Klarenbosch, Jan ; Gu, Y. John ; van Oeveren, Willem ; de Vries, Adrianus J. / Intraoperative cell salvage during cardiac surgery is associated with reduced postoperative lung injury. In: Interactive Cardiovascular and Thoracic Surgery. 2016 ; Vol. 22, No. 3. pp. 298-304.

Harvard

Engels, GE, van Klarenbosch, J, Gu, YJ, van Oeveren, W & de Vries, AJ 2016, 'Intraoperative cell salvage during cardiac surgery is associated with reduced postoperative lung injury', Interactive Cardiovascular and Thoracic Surgery, vol. 22, no. 3, pp. 298-304. https://doi.org/10.1093/icvts/ivv355

Standard

Intraoperative cell salvage during cardiac surgery is associated with reduced postoperative lung injury. / Engels, Gerwin E.; van Klarenbosch, Jan; Gu, Y. John; van Oeveren, Willem; de Vries, Adrianus J.

In: Interactive Cardiovascular and Thoracic Surgery, Vol. 22, No. 3, 03.2016, p. 298-304.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Engels GE, van Klarenbosch J, Gu YJ, van Oeveren W, de Vries AJ. Intraoperative cell salvage during cardiac surgery is associated with reduced postoperative lung injury. Interactive Cardiovascular and Thoracic Surgery. 2016 Mar;22(3):298-304. https://doi.org/10.1093/icvts/ivv355


BibTeX

@article{9329a432e0294dabb506ea86cd37813e,
title = "Intraoperative cell salvage during cardiac surgery is associated with reduced postoperative lung injury",
abstract = "OBJECTIVES: In addition to its blood-sparing effects, intraoperative cell salvage may reduce lung injury following cardiac surgery by removing cytokines, neutrophilic proteases and lipids that are present in cardiotomy suction blood. To test this hypothesis, we performed serial measurements of biomarkers of the integrity of the alveolar-capillary membrane, leucocyte activation and general inflammation. We assessed lung injury clinically by the duration of postoperative mechanical ventilation and the alveolar arterial oxygen gradient.METHODS: Serial measurements of systemic plasma concentrations of interleukin-6 (IL-6), myeloperoxidase, elastase, surfactant protein D (SP-D), Clara cell 16 kD protein (CC16) and soluble receptor for advanced glycation endproducts (sRAGEs) were performed on blood samples from 195 patients who underwent cardiac surgery with the use of a cell salvage (CS) device (CS, n = 99) or without (CONTROL, n = 96).RESULTS: Postoperative mechanical ventilation time was shorter in the CS group than in the CONTROL group [10 (8-15) vs 12 (9-18) h, respectively, P = 0.047]. The postoperative alveolar arterial oxygen gradient, however, was not different between groups. After surgery, the lung injury biomarkers CC16 and sRAGEs were lower in the CS group than in the CONTROL group. Biomarkers of systemic inflammation (IL-6, myeloperoxidase and elastase) were also lower in the CS group. Finally, mechanical ventilation time correlated with CC16 plasma concentrations.CONCLUSIONS: The intraoperative use of a cell salvage device resulted in less lung injury in patients after cardiac surgery as assessed by lower concentrations of lung injury markers and shorter mechanical ventilation times.",
keywords = "Lung, Extracorporeal circulation, CARDIOPULMONARY BYPASS, INFLAMMATORY RESPONSE, PROTEIN CC16, BLOOD, AUTOTRANSFUSION, EXPRESSION, SUCTION",
author = "Engels, {Gerwin E.} and {van Klarenbosch}, Jan and Gu, {Y. John} and {van Oeveren}, Willem and {de Vries}, {Adrianus J.}",
year = "2016",
month = "3",
doi = "10.1093/icvts/ivv355",
language = "English",
volume = "22",
pages = "298--304",
journal = "Interactive Cardiovascular and Thoracic Surgery",
issn = "1569-9293",
publisher = "Oxford University Press",
number = "3",

}

RIS

TY - JOUR

T1 - Intraoperative cell salvage during cardiac surgery is associated with reduced postoperative lung injury

AU - Engels, Gerwin E.

AU - van Klarenbosch, Jan

AU - Gu, Y. John

AU - van Oeveren, Willem

AU - de Vries, Adrianus J.

PY - 2016/3

Y1 - 2016/3

N2 - OBJECTIVES: In addition to its blood-sparing effects, intraoperative cell salvage may reduce lung injury following cardiac surgery by removing cytokines, neutrophilic proteases and lipids that are present in cardiotomy suction blood. To test this hypothesis, we performed serial measurements of biomarkers of the integrity of the alveolar-capillary membrane, leucocyte activation and general inflammation. We assessed lung injury clinically by the duration of postoperative mechanical ventilation and the alveolar arterial oxygen gradient.METHODS: Serial measurements of systemic plasma concentrations of interleukin-6 (IL-6), myeloperoxidase, elastase, surfactant protein D (SP-D), Clara cell 16 kD protein (CC16) and soluble receptor for advanced glycation endproducts (sRAGEs) were performed on blood samples from 195 patients who underwent cardiac surgery with the use of a cell salvage (CS) device (CS, n = 99) or without (CONTROL, n = 96).RESULTS: Postoperative mechanical ventilation time was shorter in the CS group than in the CONTROL group [10 (8-15) vs 12 (9-18) h, respectively, P = 0.047]. The postoperative alveolar arterial oxygen gradient, however, was not different between groups. After surgery, the lung injury biomarkers CC16 and sRAGEs were lower in the CS group than in the CONTROL group. Biomarkers of systemic inflammation (IL-6, myeloperoxidase and elastase) were also lower in the CS group. Finally, mechanical ventilation time correlated with CC16 plasma concentrations.CONCLUSIONS: The intraoperative use of a cell salvage device resulted in less lung injury in patients after cardiac surgery as assessed by lower concentrations of lung injury markers and shorter mechanical ventilation times.

AB - OBJECTIVES: In addition to its blood-sparing effects, intraoperative cell salvage may reduce lung injury following cardiac surgery by removing cytokines, neutrophilic proteases and lipids that are present in cardiotomy suction blood. To test this hypothesis, we performed serial measurements of biomarkers of the integrity of the alveolar-capillary membrane, leucocyte activation and general inflammation. We assessed lung injury clinically by the duration of postoperative mechanical ventilation and the alveolar arterial oxygen gradient.METHODS: Serial measurements of systemic plasma concentrations of interleukin-6 (IL-6), myeloperoxidase, elastase, surfactant protein D (SP-D), Clara cell 16 kD protein (CC16) and soluble receptor for advanced glycation endproducts (sRAGEs) were performed on blood samples from 195 patients who underwent cardiac surgery with the use of a cell salvage (CS) device (CS, n = 99) or without (CONTROL, n = 96).RESULTS: Postoperative mechanical ventilation time was shorter in the CS group than in the CONTROL group [10 (8-15) vs 12 (9-18) h, respectively, P = 0.047]. The postoperative alveolar arterial oxygen gradient, however, was not different between groups. After surgery, the lung injury biomarkers CC16 and sRAGEs were lower in the CS group than in the CONTROL group. Biomarkers of systemic inflammation (IL-6, myeloperoxidase and elastase) were also lower in the CS group. Finally, mechanical ventilation time correlated with CC16 plasma concentrations.CONCLUSIONS: The intraoperative use of a cell salvage device resulted in less lung injury in patients after cardiac surgery as assessed by lower concentrations of lung injury markers and shorter mechanical ventilation times.

KW - Lung

KW - Extracorporeal circulation

KW - CARDIOPULMONARY BYPASS

KW - INFLAMMATORY RESPONSE

KW - PROTEIN CC16

KW - BLOOD

KW - AUTOTRANSFUSION

KW - EXPRESSION

KW - SUCTION

U2 - 10.1093/icvts/ivv355

DO - 10.1093/icvts/ivv355

M3 - Article

VL - 22

SP - 298

EP - 304

JO - Interactive Cardiovascular and Thoracic Surgery

JF - Interactive Cardiovascular and Thoracic Surgery

SN - 1569-9293

IS - 3

ER -

ID: 41413714