Publication

Intramolecular photostabilization via triplet-state quenching: design principles to make organic fluorophores "self-healing"

van der Velde, J. H. M., Uusitalo, J. J., Ugen, L-J., Warszawik, E. M., Herrmann, A., Marrink, S. J. & Cordes, T., 2015, In : Faraday Discussions.

Research output: Contribution to journalArticleAcademicpeer-review

APA

van der Velde, J. H. M., Uusitalo, J. J., Ugen, L-J., Warszawik, E. M., Herrmann, A., Marrink, S. J., & Cordes, T. (2015). Intramolecular photostabilization via triplet-state quenching: design principles to make organic fluorophores "self-healing". Faraday Discussions. https://doi.org/10.1039/c5fd00114e

Author

van der Velde, Jasper H M ; Uusitalo, Jaakko J ; Ugen, Lourens-Jan ; Warszawik, Eliza M ; Herrmann, Andreas ; Marrink, Siewert J ; Cordes, Thorben. / Intramolecular photostabilization via triplet-state quenching : design principles to make organic fluorophores "self-healing". In: Faraday Discussions. 2015.

Harvard

van der Velde, JHM, Uusitalo, JJ, Ugen, L-J, Warszawik, EM, Herrmann, A, Marrink, SJ & Cordes, T 2015, 'Intramolecular photostabilization via triplet-state quenching: design principles to make organic fluorophores "self-healing"', Faraday Discussions. https://doi.org/10.1039/c5fd00114e

Standard

Intramolecular photostabilization via triplet-state quenching : design principles to make organic fluorophores "self-healing". / van der Velde, Jasper H M; Uusitalo, Jaakko J; Ugen, Lourens-Jan; Warszawik, Eliza M; Herrmann, Andreas; Marrink, Siewert J; Cordes, Thorben.

In: Faraday Discussions, 2015.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

van der Velde JHM, Uusitalo JJ, Ugen L-J, Warszawik EM, Herrmann A, Marrink SJ et al. Intramolecular photostabilization via triplet-state quenching: design principles to make organic fluorophores "self-healing". Faraday Discussions. 2015. https://doi.org/10.1039/c5fd00114e


BibTeX

@article{c9430b7bffba44158c021668641dfdda,
title = "Intramolecular photostabilization via triplet-state quenching: design principles to make organic fluorophores {"}self-healing{"}",
abstract = "Covalent linkage of fluorophores and photostabilizers was recently revived as a strategy to make organic fluorophores {"}self-healing{"} via triplet-state quenching. Although L{\"u}ttke and co-workers pioneered this strategy already in the 1980s, the general design principles still remain elusive. In this contribution, we combine experiments and theory to understand what determines the photostabilization efficiency in dye-photostabilizer conjugates. Our results from single-molecule microscopy and molecular dynamics simulations of different Cy5-derivatives suggest that the distance and relative geometry between the fluorophore and photostabilizer are more important than the chemical nature of the photostabilizer, e.g. its redox potential, which is known to influence electron-transfer rates. We hypothesize that the efficiency of photostabilization scales directly with the contact rate of the fluorophore and photostabilizer. This study represents an important step in the understanding of the molecular mechanism of intramolecular photostabilization and can pave the way for further development of stable emitters for various applications.",
keywords = "HYDRATION, DYNAMICS, MOLECULE FLUORESCENCE SPECTROSCOPY, LASER-DYES, CYANINE FLUOROPHORES, OXIDIZING SYSTEM, ENERGY-TRANSFER, PHOTOPHYSICS, MICROSCOPY, MECHANISM",
author = "{van der Velde}, {Jasper H M} and Uusitalo, {Jaakko J} and Lourens-Jan Ugen and Warszawik, {Eliza M} and Andreas Herrmann and Marrink, {Siewert J} and Thorben Cordes",
year = "2015",
doi = "10.1039/c5fd00114e",
language = "English",
journal = "Faraday Discussions",
issn = "1364-5498",
publisher = "ROYAL SOC CHEMISTRY",

}

RIS

TY - JOUR

T1 - Intramolecular photostabilization via triplet-state quenching

T2 - design principles to make organic fluorophores "self-healing"

AU - van der Velde, Jasper H M

AU - Uusitalo, Jaakko J

AU - Ugen, Lourens-Jan

AU - Warszawik, Eliza M

AU - Herrmann, Andreas

AU - Marrink, Siewert J

AU - Cordes, Thorben

PY - 2015

Y1 - 2015

N2 - Covalent linkage of fluorophores and photostabilizers was recently revived as a strategy to make organic fluorophores "self-healing" via triplet-state quenching. Although Lüttke and co-workers pioneered this strategy already in the 1980s, the general design principles still remain elusive. In this contribution, we combine experiments and theory to understand what determines the photostabilization efficiency in dye-photostabilizer conjugates. Our results from single-molecule microscopy and molecular dynamics simulations of different Cy5-derivatives suggest that the distance and relative geometry between the fluorophore and photostabilizer are more important than the chemical nature of the photostabilizer, e.g. its redox potential, which is known to influence electron-transfer rates. We hypothesize that the efficiency of photostabilization scales directly with the contact rate of the fluorophore and photostabilizer. This study represents an important step in the understanding of the molecular mechanism of intramolecular photostabilization and can pave the way for further development of stable emitters for various applications.

AB - Covalent linkage of fluorophores and photostabilizers was recently revived as a strategy to make organic fluorophores "self-healing" via triplet-state quenching. Although Lüttke and co-workers pioneered this strategy already in the 1980s, the general design principles still remain elusive. In this contribution, we combine experiments and theory to understand what determines the photostabilization efficiency in dye-photostabilizer conjugates. Our results from single-molecule microscopy and molecular dynamics simulations of different Cy5-derivatives suggest that the distance and relative geometry between the fluorophore and photostabilizer are more important than the chemical nature of the photostabilizer, e.g. its redox potential, which is known to influence electron-transfer rates. We hypothesize that the efficiency of photostabilization scales directly with the contact rate of the fluorophore and photostabilizer. This study represents an important step in the understanding of the molecular mechanism of intramolecular photostabilization and can pave the way for further development of stable emitters for various applications.

KW - HYDRATION

KW - DYNAMICS

KW - MOLECULE FLUORESCENCE SPECTROSCOPY

KW - LASER-DYES

KW - CYANINE FLUOROPHORES

KW - OXIDIZING SYSTEM

KW - ENERGY-TRANSFER

KW - PHOTOPHYSICS

KW - MICROSCOPY

KW - MECHANISM

U2 - 10.1039/c5fd00114e

DO - 10.1039/c5fd00114e

M3 - Article

JO - Faraday Discussions

JF - Faraday Discussions

SN - 1364-5498

ER -

ID: 25190582