Publication

INTRACEREBROVENTRICULAR APPLICATION OF COMPETITIVE AND NONCOMPETITIVE NMDA ANTAGONISTS INDUCE SIMILAR EFFECTS UPON RAT HIPPOCAMPAL ELECTROENCEPHALOGRAM AND LOCAL CEREBRAL GLUCOSE-UTILIZATION

BODDEKE, HWGM., WIEDERHOLD, KH. & PALACIOS, JM., 10-Jul-1992, In : Brain Research. 585, 1-2, p. 177-183 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

BODDEKE, HWGM., WIEDERHOLD, KH., & PALACIOS, JM. (1992). INTRACEREBROVENTRICULAR APPLICATION OF COMPETITIVE AND NONCOMPETITIVE NMDA ANTAGONISTS INDUCE SIMILAR EFFECTS UPON RAT HIPPOCAMPAL ELECTROENCEPHALOGRAM AND LOCAL CEREBRAL GLUCOSE-UTILIZATION. Brain Research, 585(1-2), 177-183.

Author

BODDEKE, HWGM ; WIEDERHOLD, KH ; PALACIOS, JM. / INTRACEREBROVENTRICULAR APPLICATION OF COMPETITIVE AND NONCOMPETITIVE NMDA ANTAGONISTS INDUCE SIMILAR EFFECTS UPON RAT HIPPOCAMPAL ELECTROENCEPHALOGRAM AND LOCAL CEREBRAL GLUCOSE-UTILIZATION. In: Brain Research. 1992 ; Vol. 585, No. 1-2. pp. 177-183.

Harvard

BODDEKE, HWGM, WIEDERHOLD, KH & PALACIOS, JM 1992, 'INTRACEREBROVENTRICULAR APPLICATION OF COMPETITIVE AND NONCOMPETITIVE NMDA ANTAGONISTS INDUCE SIMILAR EFFECTS UPON RAT HIPPOCAMPAL ELECTROENCEPHALOGRAM AND LOCAL CEREBRAL GLUCOSE-UTILIZATION', Brain Research, vol. 585, no. 1-2, pp. 177-183.

Standard

INTRACEREBROVENTRICULAR APPLICATION OF COMPETITIVE AND NONCOMPETITIVE NMDA ANTAGONISTS INDUCE SIMILAR EFFECTS UPON RAT HIPPOCAMPAL ELECTROENCEPHALOGRAM AND LOCAL CEREBRAL GLUCOSE-UTILIZATION. / BODDEKE, HWGM; WIEDERHOLD, KH; PALACIOS, JM.

In: Brain Research, Vol. 585, No. 1-2, 10.07.1992, p. 177-183.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

BODDEKE HWGM, WIEDERHOLD KH, PALACIOS JM. INTRACEREBROVENTRICULAR APPLICATION OF COMPETITIVE AND NONCOMPETITIVE NMDA ANTAGONISTS INDUCE SIMILAR EFFECTS UPON RAT HIPPOCAMPAL ELECTROENCEPHALOGRAM AND LOCAL CEREBRAL GLUCOSE-UTILIZATION. Brain Research. 1992 Jul 10;585(1-2):177-183.


BibTeX

@article{54790b44498943c294268ee41a650479,
title = "INTRACEREBROVENTRICULAR APPLICATION OF COMPETITIVE AND NONCOMPETITIVE NMDA ANTAGONISTS INDUCE SIMILAR EFFECTS UPON RAT HIPPOCAMPAL ELECTROENCEPHALOGRAM AND LOCAL CEREBRAL GLUCOSE-UTILIZATION",
abstract = "In this study we have used electrophysiological and metabolic markers to investigate the effects of competitive and non-competitive NMDA antagonists in rats after central or peripheral administration. The non-competitive antagonist, MK-801, induced dose-dependent suppression of rat hippocampal EEG energy both after intraperitoneal (i.p.) and intracerebroventricular (i.c.v.) application. Similar effects were observed after i.p. and i.c.v. application of the competitive antagonist, DL-CPP-ene. Whereas the MK-801 was more potent after i.p. application, DL-CPP-ene was more potent after i.c.v. administration. Intracerebroventricular administration of MK-801 and DL-CPP-ene resulted in similar changes in the pattern of local cerebral glucose utilization in the olfactory tubercle and regions of the limbic system such as the anteroventral thalamus, hippocampus and entorhinal cortex. Intravenous (i.v.) administration of MK-801 induced increases in glucose metabolism similar to those observed after i.c.v. application. In contrast, i.v. administration of DL-CPP-ene induced only small decreases of glucose utilization in several regions of the central sensory system. Thus the blockade of glutamatergic (NMDA) transmission results in decreased hippocampal EEG activity which is paralleled by increased metabolic activity in this area. We conclude from EEG recordings and [C-14]2-deoxyglucose uptake experiments that both non-competitive and competitive NMDA antagonists produce the same pattern of alterations after i.c.v. administration. Apparent differences in efficacy after peripheral administration may be largely due to differences in bioavaliability.",
keywords = "HIPPOCAMPAL ELECTROENCEPHALOGRAM, 2-DEOXYGLUCOSE UTILIZATION, COMPETITIVE NONCOMPETITIVE ANTAGONIST, ASPARTATE RECEPTOR ANTAGONIST, GLUTAMATE RECEPTOR, MK-801, EXPRESSION, BRAIN, AGONISTS, BLOCKADE, PROTECT, FAMILY, CPP",
author = "HWGM BODDEKE and KH WIEDERHOLD and JM PALACIOS",
year = "1992",
month = "7",
day = "10",
language = "English",
volume = "585",
pages = "177--183",
journal = "Brain Research",
issn = "0006-8993",
publisher = "ELSEVIER SCIENCE BV",
number = "1-2",

}

RIS

TY - JOUR

T1 - INTRACEREBROVENTRICULAR APPLICATION OF COMPETITIVE AND NONCOMPETITIVE NMDA ANTAGONISTS INDUCE SIMILAR EFFECTS UPON RAT HIPPOCAMPAL ELECTROENCEPHALOGRAM AND LOCAL CEREBRAL GLUCOSE-UTILIZATION

AU - BODDEKE, HWGM

AU - WIEDERHOLD, KH

AU - PALACIOS, JM

PY - 1992/7/10

Y1 - 1992/7/10

N2 - In this study we have used electrophysiological and metabolic markers to investigate the effects of competitive and non-competitive NMDA antagonists in rats after central or peripheral administration. The non-competitive antagonist, MK-801, induced dose-dependent suppression of rat hippocampal EEG energy both after intraperitoneal (i.p.) and intracerebroventricular (i.c.v.) application. Similar effects were observed after i.p. and i.c.v. application of the competitive antagonist, DL-CPP-ene. Whereas the MK-801 was more potent after i.p. application, DL-CPP-ene was more potent after i.c.v. administration. Intracerebroventricular administration of MK-801 and DL-CPP-ene resulted in similar changes in the pattern of local cerebral glucose utilization in the olfactory tubercle and regions of the limbic system such as the anteroventral thalamus, hippocampus and entorhinal cortex. Intravenous (i.v.) administration of MK-801 induced increases in glucose metabolism similar to those observed after i.c.v. application. In contrast, i.v. administration of DL-CPP-ene induced only small decreases of glucose utilization in several regions of the central sensory system. Thus the blockade of glutamatergic (NMDA) transmission results in decreased hippocampal EEG activity which is paralleled by increased metabolic activity in this area. We conclude from EEG recordings and [C-14]2-deoxyglucose uptake experiments that both non-competitive and competitive NMDA antagonists produce the same pattern of alterations after i.c.v. administration. Apparent differences in efficacy after peripheral administration may be largely due to differences in bioavaliability.

AB - In this study we have used electrophysiological and metabolic markers to investigate the effects of competitive and non-competitive NMDA antagonists in rats after central or peripheral administration. The non-competitive antagonist, MK-801, induced dose-dependent suppression of rat hippocampal EEG energy both after intraperitoneal (i.p.) and intracerebroventricular (i.c.v.) application. Similar effects were observed after i.p. and i.c.v. application of the competitive antagonist, DL-CPP-ene. Whereas the MK-801 was more potent after i.p. application, DL-CPP-ene was more potent after i.c.v. administration. Intracerebroventricular administration of MK-801 and DL-CPP-ene resulted in similar changes in the pattern of local cerebral glucose utilization in the olfactory tubercle and regions of the limbic system such as the anteroventral thalamus, hippocampus and entorhinal cortex. Intravenous (i.v.) administration of MK-801 induced increases in glucose metabolism similar to those observed after i.c.v. application. In contrast, i.v. administration of DL-CPP-ene induced only small decreases of glucose utilization in several regions of the central sensory system. Thus the blockade of glutamatergic (NMDA) transmission results in decreased hippocampal EEG activity which is paralleled by increased metabolic activity in this area. We conclude from EEG recordings and [C-14]2-deoxyglucose uptake experiments that both non-competitive and competitive NMDA antagonists produce the same pattern of alterations after i.c.v. administration. Apparent differences in efficacy after peripheral administration may be largely due to differences in bioavaliability.

KW - HIPPOCAMPAL ELECTROENCEPHALOGRAM

KW - 2-DEOXYGLUCOSE UTILIZATION

KW - COMPETITIVE NONCOMPETITIVE ANTAGONIST

KW - ASPARTATE RECEPTOR ANTAGONIST

KW - GLUTAMATE RECEPTOR

KW - MK-801

KW - EXPRESSION

KW - BRAIN

KW - AGONISTS

KW - BLOCKADE

KW - PROTECT

KW - FAMILY

KW - CPP

M3 - Article

VL - 585

SP - 177

EP - 183

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1-2

ER -

ID: 14149004