Publication

Intestinal microbiome composition and its relation to joint pain and inflammation

Boer, C. G., Radjabzadeh, D., Medina-Gomez, C., Garmaeva, S., Schiphof, D., Arp, P., Koet, T., Kurilshikov, A., Fu, J., Ikram, M. A., Bierma-Zeinstra, S., Uitterlinden, A. G., Kraaij, R., Zhernakova, A. & van Meurs, J. B. J., 25-Oct-2019, In : Nature Communications. 10, 9 p., 4881.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Boer, C. G., Radjabzadeh, D., Medina-Gomez, C., Garmaeva, S., Schiphof, D., Arp, P., ... van Meurs, J. B. J. (2019). Intestinal microbiome composition and its relation to joint pain and inflammation. Nature Communications, 10, [4881]. https://doi.org/10.1038/s41467-019-12873-4

Author

Boer, Cindy G. ; Radjabzadeh, Djawad ; Medina-Gomez, Carolina ; Garmaeva, Sanzhima ; Schiphof, Dieuwke ; Arp, Pascal ; Koet, Thomas ; Kurilshikov, Alexander ; Fu, Jingyuan ; Ikram, M. Arfan ; Bierma-Zeinstra, Sita ; Uitterlinden, Andre G. ; Kraaij, Robert ; Zhernakova, Alexandra ; van Meurs, Joyce B. J. / Intestinal microbiome composition and its relation to joint pain and inflammation. In: Nature Communications. 2019 ; Vol. 10.

Harvard

Boer, CG, Radjabzadeh, D, Medina-Gomez, C, Garmaeva, S, Schiphof, D, Arp, P, Koet, T, Kurilshikov, A, Fu, J, Ikram, MA, Bierma-Zeinstra, S, Uitterlinden, AG, Kraaij, R, Zhernakova, A & van Meurs, JBJ 2019, 'Intestinal microbiome composition and its relation to joint pain and inflammation', Nature Communications, vol. 10, 4881. https://doi.org/10.1038/s41467-019-12873-4

Standard

Intestinal microbiome composition and its relation to joint pain and inflammation. / Boer, Cindy G.; Radjabzadeh, Djawad; Medina-Gomez, Carolina; Garmaeva, Sanzhima; Schiphof, Dieuwke; Arp, Pascal; Koet, Thomas; Kurilshikov, Alexander; Fu, Jingyuan; Ikram, M. Arfan; Bierma-Zeinstra, Sita; Uitterlinden, Andre G.; Kraaij, Robert; Zhernakova, Alexandra; van Meurs, Joyce B. J.

In: Nature Communications, Vol. 10, 4881, 25.10.2019.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Boer CG, Radjabzadeh D, Medina-Gomez C, Garmaeva S, Schiphof D, Arp P et al. Intestinal microbiome composition and its relation to joint pain and inflammation. Nature Communications. 2019 Oct 25;10. 4881. https://doi.org/10.1038/s41467-019-12873-4


BibTeX

@article{4379b0b99d7f4adf81d74e657425dc98,
title = "Intestinal microbiome composition and its relation to joint pain and inflammation",
abstract = "Macrophage-mediated inflammation is thought to have a causal role in osteoarthritis-related pain and severity, and has been suggested to be triggered by endotoxins produced by the gastrointestinal microbiome. Here we investigate the relationship between joint pain and the gastrointestinal microbiome composition, and osteoarthritis-related knee pain in the Rotterdam Study; a large population based cohort study. We show that abundance of Streptococcus species is associated with increased knee pain, which we validate by absolute quantification of Streptococcus species. In addition, we replicate these results in 867 Caucasian adults of the Lifelines-DEEP study. Finally we show evidence that this association is driven by local inflammation in the knee joint. Our results indicate the microbiome is a possible therapeutic target for osteoarthritis-related knee pain.",
keywords = "GUT MICROBIOME, KNEE OSTEOARTHRITIS, RHEUMATIC-FEVER, UNITED-STATES, OBESE MICE, PATHOGENESIS, ASSOCIATION, MACROPHAGES, PREVALENCE, DISABILITY",
author = "Boer, {Cindy G.} and Djawad Radjabzadeh and Carolina Medina-Gomez and Sanzhima Garmaeva and Dieuwke Schiphof and Pascal Arp and Thomas Koet and Alexander Kurilshikov and Jingyuan Fu and Ikram, {M. Arfan} and Sita Bierma-Zeinstra and Uitterlinden, {Andre G.} and Robert Kraaij and Alexandra Zhernakova and {van Meurs}, {Joyce B. J.}",
year = "2019",
month = "10",
day = "25",
doi = "10.1038/s41467-019-12873-4",
language = "English",
volume = "10",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Intestinal microbiome composition and its relation to joint pain and inflammation

AU - Boer, Cindy G.

AU - Radjabzadeh, Djawad

AU - Medina-Gomez, Carolina

AU - Garmaeva, Sanzhima

AU - Schiphof, Dieuwke

AU - Arp, Pascal

AU - Koet, Thomas

AU - Kurilshikov, Alexander

AU - Fu, Jingyuan

AU - Ikram, M. Arfan

AU - Bierma-Zeinstra, Sita

AU - Uitterlinden, Andre G.

AU - Kraaij, Robert

AU - Zhernakova, Alexandra

AU - van Meurs, Joyce B. J.

PY - 2019/10/25

Y1 - 2019/10/25

N2 - Macrophage-mediated inflammation is thought to have a causal role in osteoarthritis-related pain and severity, and has been suggested to be triggered by endotoxins produced by the gastrointestinal microbiome. Here we investigate the relationship between joint pain and the gastrointestinal microbiome composition, and osteoarthritis-related knee pain in the Rotterdam Study; a large population based cohort study. We show that abundance of Streptococcus species is associated with increased knee pain, which we validate by absolute quantification of Streptococcus species. In addition, we replicate these results in 867 Caucasian adults of the Lifelines-DEEP study. Finally we show evidence that this association is driven by local inflammation in the knee joint. Our results indicate the microbiome is a possible therapeutic target for osteoarthritis-related knee pain.

AB - Macrophage-mediated inflammation is thought to have a causal role in osteoarthritis-related pain and severity, and has been suggested to be triggered by endotoxins produced by the gastrointestinal microbiome. Here we investigate the relationship between joint pain and the gastrointestinal microbiome composition, and osteoarthritis-related knee pain in the Rotterdam Study; a large population based cohort study. We show that abundance of Streptococcus species is associated with increased knee pain, which we validate by absolute quantification of Streptococcus species. In addition, we replicate these results in 867 Caucasian adults of the Lifelines-DEEP study. Finally we show evidence that this association is driven by local inflammation in the knee joint. Our results indicate the microbiome is a possible therapeutic target for osteoarthritis-related knee pain.

KW - GUT MICROBIOME

KW - KNEE OSTEOARTHRITIS

KW - RHEUMATIC-FEVER

KW - UNITED-STATES

KW - OBESE MICE

KW - PATHOGENESIS

KW - ASSOCIATION

KW - MACROPHAGES

KW - PREVALENCE

KW - DISABILITY

U2 - 10.1038/s41467-019-12873-4

DO - 10.1038/s41467-019-12873-4

M3 - Article

VL - 10

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 4881

ER -

ID: 118420567