Publication

Interplay between dietary fibers and gut microbiota for promoting metabolic health

Mistry, R., 2019, [Groningen]: University of Groningen. 145 p.

Research output: ThesisThesis fully internal (DIV)Academic

APA

Mistry, R. (2019). Interplay between dietary fibers and gut microbiota for promoting metabolic health. [Groningen]: University of Groningen.

Author

Mistry, Rima. / Interplay between dietary fibers and gut microbiota for promoting metabolic health. [Groningen] : University of Groningen, 2019. 145 p.

Harvard

Mistry, R 2019, 'Interplay between dietary fibers and gut microbiota for promoting metabolic health', Doctor of Philosophy, University of Groningen, [Groningen].

Standard

Interplay between dietary fibers and gut microbiota for promoting metabolic health. / Mistry, Rima.

[Groningen] : University of Groningen, 2019. 145 p.

Research output: ThesisThesis fully internal (DIV)Academic

Vancouver

Mistry R. Interplay between dietary fibers and gut microbiota for promoting metabolic health. [Groningen]: University of Groningen, 2019. 145 p.


BibTeX

@phdthesis{96906816213d49438ffdf317e59a44a6,
title = "Interplay between dietary fibers and gut microbiota for promoting metabolic health",
abstract = "Metabolic syndrome is a cluster of several metabolic disorders such as insulin resistance, obesity, type 2 diabetes, dyslipidemia, non-alcoholic fatty liver disease and hypertension, whose prevalence has rapidly increased over the last decades. Unhealthy dietary and lifestyle changes have contributed considerably to this rise. Gastrointestinal microbiota has received increasing interest as a preventive or therapeutic target particularly for its impact on the host metabolism. Dietary fibers are substrates for growth of specific beneficial bacterial species and as a result can shift the microbial population towards a (more) healthy composition. Bacterial fermentation products of dietary fibers are bioactive metabolites such as short-chain fatty acids (SCFA) which can regulate various metabolic processes in the mammalian host. Despite the potential impact of dietary fibers on intestinal microbiota and host metabolism, the underlying mechanism of action has not been elucidated in great depth. In this thesis, we aimed to explore the role of different dietary fibers in manipulating gastrointestinal microbiota and subsequently its impact on metabolic health in mouse models. In the first part of the thesis (chapter 2 and 3) we focused on in-depth investigation of dietary fibers and its potential impact on various metabolic parameters. In chapter 4 and 5, we investigated the importance of gastrointestinal microbiota in atheroprotective pathways and whether dietary fiber such β-cyclodextrin could enhance the pathway, using germ-free mice. In chapter 6 we assessed the long-term metabolic health effects of supplementing galacto-oligosaccharide to Western-type diet.",
author = "Rima Mistry",
year = "2019",
language = "English",
isbn = "978-94-034-1503-1",
publisher = "University of Groningen",
school = "University of Groningen",

}

RIS

TY - THES

T1 - Interplay between dietary fibers and gut microbiota for promoting metabolic health

AU - Mistry, Rima

PY - 2019

Y1 - 2019

N2 - Metabolic syndrome is a cluster of several metabolic disorders such as insulin resistance, obesity, type 2 diabetes, dyslipidemia, non-alcoholic fatty liver disease and hypertension, whose prevalence has rapidly increased over the last decades. Unhealthy dietary and lifestyle changes have contributed considerably to this rise. Gastrointestinal microbiota has received increasing interest as a preventive or therapeutic target particularly for its impact on the host metabolism. Dietary fibers are substrates for growth of specific beneficial bacterial species and as a result can shift the microbial population towards a (more) healthy composition. Bacterial fermentation products of dietary fibers are bioactive metabolites such as short-chain fatty acids (SCFA) which can regulate various metabolic processes in the mammalian host. Despite the potential impact of dietary fibers on intestinal microbiota and host metabolism, the underlying mechanism of action has not been elucidated in great depth. In this thesis, we aimed to explore the role of different dietary fibers in manipulating gastrointestinal microbiota and subsequently its impact on metabolic health in mouse models. In the first part of the thesis (chapter 2 and 3) we focused on in-depth investigation of dietary fibers and its potential impact on various metabolic parameters. In chapter 4 and 5, we investigated the importance of gastrointestinal microbiota in atheroprotective pathways and whether dietary fiber such β-cyclodextrin could enhance the pathway, using germ-free mice. In chapter 6 we assessed the long-term metabolic health effects of supplementing galacto-oligosaccharide to Western-type diet.

AB - Metabolic syndrome is a cluster of several metabolic disorders such as insulin resistance, obesity, type 2 diabetes, dyslipidemia, non-alcoholic fatty liver disease and hypertension, whose prevalence has rapidly increased over the last decades. Unhealthy dietary and lifestyle changes have contributed considerably to this rise. Gastrointestinal microbiota has received increasing interest as a preventive or therapeutic target particularly for its impact on the host metabolism. Dietary fibers are substrates for growth of specific beneficial bacterial species and as a result can shift the microbial population towards a (more) healthy composition. Bacterial fermentation products of dietary fibers are bioactive metabolites such as short-chain fatty acids (SCFA) which can regulate various metabolic processes in the mammalian host. Despite the potential impact of dietary fibers on intestinal microbiota and host metabolism, the underlying mechanism of action has not been elucidated in great depth. In this thesis, we aimed to explore the role of different dietary fibers in manipulating gastrointestinal microbiota and subsequently its impact on metabolic health in mouse models. In the first part of the thesis (chapter 2 and 3) we focused on in-depth investigation of dietary fibers and its potential impact on various metabolic parameters. In chapter 4 and 5, we investigated the importance of gastrointestinal microbiota in atheroprotective pathways and whether dietary fiber such β-cyclodextrin could enhance the pathway, using germ-free mice. In chapter 6 we assessed the long-term metabolic health effects of supplementing galacto-oligosaccharide to Western-type diet.

M3 - Thesis fully internal (DIV)

SN - 978-94-034-1503-1

PB - University of Groningen

CY - [Groningen]

ER -

ID: 77592085