Interferon AnalogsPoelstra, K., Prakash, J., Beljaars, E. & Bansal, R., 14-Mar-2013, (Submitted) IPC No. A61K38/21, Patent No. US2013064791A1, Priority date 31-Dec-2099, Priority No. US201013519808 20101230
Research output: Patent › Professional
The invention relates to the field of medicine. Among others, it relates to biologically active analogs of interferons (IFNs) which show less unwanted side-effects and to the therapeutic uses thereof. Provided is an IFN analog, wherein the moiety mediating binding to its natural receptor is at least functionally disrupted and wherein the analog comprises a signaling moiety capable of mediating intracellular IFN activity, said signaling moiety being provided at its N-terminus, optionally via a linker, with at least one targeting domain capable of binding to a cell surface receptor other than the IFN receptor.
|Publication status||Submitted - 14-Mar-2013|