Publication

Interethnic analyses of blood pressure loci in populations of East Asian and European descent

Int Genomics Blood Pressure & van der Harst, P., 28-Nov-2018, In : Nature Communications. 9, 16 p., 5052.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Int Genomics Blood Pressure, & van der Harst, P. (2018). Interethnic analyses of blood pressure loci in populations of East Asian and European descent. Nature Communications, 9, [5052]. https://doi.org/10.1038/s41467-018-07345-0

Author

Int Genomics Blood Pressure ; van der Harst, Pim. / Interethnic analyses of blood pressure loci in populations of East Asian and European descent. In: Nature Communications. 2018 ; Vol. 9.

Harvard

Int Genomics Blood Pressure & van der Harst, P 2018, 'Interethnic analyses of blood pressure loci in populations of East Asian and European descent' Nature Communications, vol. 9, 5052. https://doi.org/10.1038/s41467-018-07345-0

Standard

Interethnic analyses of blood pressure loci in populations of East Asian and European descent. / Int Genomics Blood Pressure ; van der Harst, Pim.

In: Nature Communications, Vol. 9, 5052, 28.11.2018.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Int Genomics Blood Pressure, van der Harst P. Interethnic analyses of blood pressure loci in populations of East Asian and European descent. Nature Communications. 2018 Nov 28;9. 5052. https://doi.org/10.1038/s41467-018-07345-0


BibTeX

@article{19d8f5f5898e4d05bd8097d2633f8c86,
title = "Interethnic analyses of blood pressure loci in populations of East Asian and European descent",
abstract = "Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP ( max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.",
keywords = "GENOME-WIDE ASSOCIATION, BODY-MASS INDEX, LINKAGE DISEQUILIBRIUM, CARDIOVASCULAR-DISEASE, FUNCTIONAL ANNOTATION, RARE VARIANTS, COMMON, METAANALYSIS, HERITABILITY, ARCHITECTURE",
author = "{Int Genomics Blood Pressure} and Fumihiko Takeuchi and Masato Akiyama and Nana Matoba and Tomohiro Katsuya and Masahiro Nakatochi and Yasuharu Tabara and Akira Narita and Woei-Yuh Saw and Sanghoon Moon and Spracklen, {Cassandra N.} and Jin-Fang Chai and Young-Jin Kim and Liang Zhang and Chaolong Wang and Huaixing Li and Honglan Li and Jer-Yuarn Wu and Rajkumar Dorajoo and Nierenberg, {Jovia L.} and Wang, {Ya Xing} and Jing He and Bennett, {Derrick A.} and Atsushi Takahashi and Yukihide Momozawa and Makoto Hirata and Koichi Matsuda and Hiromi Rakugi and Eitaro Nakashima and Masato Isono and Matsuyuki Shirota and Atsushi Hozawa and Sahoko Ichihara and Tatsuaki Matsubara and Ken Yamamoto and Katsuhiko Kohara and Michiya Igase and Sohee Han and Penny Gordon-Larsen and Wei Huang and Lee, {Nanette R.} and Adair, {Linda S.} and Hwang, {Mi Yeong} and Juyoung Lee and Chee, {Miao Li} and Charumathi Sabanayagam and Wanting Zhao and Jianjun Liu and Reilly, {Dermot F.} and Liang Xu and {van der Harst}, Pim",
year = "2018",
month = "11",
day = "28",
doi = "10.1038/s41467-018-07345-0",
language = "English",
volume = "9",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Interethnic analyses of blood pressure loci in populations of East Asian and European descent

AU - Int Genomics Blood Pressure

AU - Takeuchi, Fumihiko

AU - Akiyama, Masato

AU - Matoba, Nana

AU - Katsuya, Tomohiro

AU - Nakatochi, Masahiro

AU - Tabara, Yasuharu

AU - Narita, Akira

AU - Saw, Woei-Yuh

AU - Moon, Sanghoon

AU - Spracklen, Cassandra N.

AU - Chai, Jin-Fang

AU - Kim, Young-Jin

AU - Zhang, Liang

AU - Wang, Chaolong

AU - Li, Huaixing

AU - Li, Honglan

AU - Wu, Jer-Yuarn

AU - Dorajoo, Rajkumar

AU - Nierenberg, Jovia L.

AU - Wang, Ya Xing

AU - He, Jing

AU - Bennett, Derrick A.

AU - Takahashi, Atsushi

AU - Momozawa, Yukihide

AU - Hirata, Makoto

AU - Matsuda, Koichi

AU - Rakugi, Hiromi

AU - Nakashima, Eitaro

AU - Isono, Masato

AU - Shirota, Matsuyuki

AU - Hozawa, Atsushi

AU - Ichihara, Sahoko

AU - Matsubara, Tatsuaki

AU - Yamamoto, Ken

AU - Kohara, Katsuhiko

AU - Igase, Michiya

AU - Han, Sohee

AU - Gordon-Larsen, Penny

AU - Huang, Wei

AU - Lee, Nanette R.

AU - Adair, Linda S.

AU - Hwang, Mi Yeong

AU - Lee, Juyoung

AU - Chee, Miao Li

AU - Sabanayagam, Charumathi

AU - Zhao, Wanting

AU - Liu, Jianjun

AU - Reilly, Dermot F.

AU - Xu, Liang

AU - van der Harst, Pim

PY - 2018/11/28

Y1 - 2018/11/28

N2 - Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP ( max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.

AB - Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP ( max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.

KW - GENOME-WIDE ASSOCIATION

KW - BODY-MASS INDEX

KW - LINKAGE DISEQUILIBRIUM

KW - CARDIOVASCULAR-DISEASE

KW - FUNCTIONAL ANNOTATION

KW - RARE VARIANTS

KW - COMMON

KW - METAANALYSIS

KW - HERITABILITY

KW - ARCHITECTURE

U2 - 10.1038/s41467-018-07345-0

DO - 10.1038/s41467-018-07345-0

M3 - Article

VL - 9

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 5052

ER -

ID: 76699740