Publication

Interactions between noradrenaline and corticosteroids in the brain: From electrical activity to cognitive performance

Krugers, H. J., Karst, H. & Joels, M., 9-Apr-2012, In : Frontiers in cellular neuroscience. 6, 10 p., 15.

Research output: Contribution to journalReview articleAcademicpeer-review

One of the core reactions in response to a stressful situation is the activation of the hypothalamus -pituitary-adrenal axis which increases the release of glucocorticoid hormones from the adrenal glands. In concert with other neuro-modulators, such as (nor)adrenaline, these hormones enable and promote cognitive adaptation to stressful events. Recent studies have demonstrated that glucocorticoid hormones and noradrenaline, via their receptors, can both rapidly and persistently regulate the function of excitatory synapses which are critical for storage of information. Here we will review how glucocorticoids and noradrenaline alone and in synergy dynamically tune these synapses in the hippocampus and amygdala, and discuss how these hormones interact to promote behavioral adaptation to stressful situations.

Original languageEnglish
Article number15
Number of pages10
JournalFrontiers in cellular neuroscience
Volume6
Publication statusPublished - 9-Apr-2012
Externally publishedYes

    Keywords

  • hippocampus, amygdala, mouse, electrophysiology, glutamate, AMPA-RECEPTOR TRAFFICKING, LONG-TERM POTENTIATION, STRESS HORMONE CORTICOSTERONE, BETA-ADRENERGIC MODULATION, POST-TRAINING INJECTIONS, HIPPOCAMPAL CA1 REGION, BASOLATERAL AMYGDALA, SYNAPTIC PLASTICITY, EMOTIONAL MEMORY, GLUCOCORTICOID-RECEPTORS

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