Publication

Interaction between host T cells and Reed-Sternberg cells in Hodgkin lymphomas

Poppema, S. & van den Berg, A. Oct-2000 In : Seminars in cancer biology. 10, 5, p. 345-350 6 p.

Research output: Contribution to journalArticle

Recent studies provide evidence that Reed-Sternberg (R-S) cells produce factors that may explain the characteristic inflammatory infiltrate in the affected tissues of Hodgkin lymphoma. The various chemokines and cytokines that are produced lead to a preferential influx of Th2-type T cells and suppress Th1-type immune responses. Overall, the immunophenotype of the lymphocytes surrounding the R-S cells is consistent with anergic and/or Th2-type T cells. Therefore, these cells do not support a cytotoxic anti-tumor response. Since the R-S cells are neoplastic B cells, the cytokines produced by these T cells may in fact help their growth and/or survival. The production and induction of various other cytokines may also explain the influx of eosinophils (IL-5, eotaxin) and plasma cells (IL-6). Differences in chemokine and cytokine production may be responible for the differences between the histological subtypes.

Original languageEnglish
Pages (from-to)345-350
Number of pages6
JournalSeminars in cancer biology
Volume10
Issue number5
StatePublished - Oct-2000

    Keywords

  • Hodgkin, chemokine, cytokine, TARC, TGF beta, CC-CHEMOKINE TARC, KAPPA-B-ALPHA, IN-VIVO, DISEASE, EXPRESSION, LYMPHOCYTES, TUMOR, INTERLEUKIN-10, MUTATIONS, INVOLVEMENT

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