Publication

Inter- and intrascanner variability of pulmonary nodule volumetry on low-dose 64-row CT: an anthropomorphic phantom study

Xie, X., Willemink, M. J., Zhao, Y., de Jong, P. A., van Ooijen, P. M. A., Oudkerk, M., Greuter, M. J. W. & Vliegenthart, R., Sep-2013, In : British journal of radiology. 86, 1029, 9 p., 20130160.

Research output: Contribution to journalArticleAcademicpeer-review

Objective: To assess inter- and intrascanner variability in volumetry of solid pulmonary nodules in an anthropomorphic thoracic phantom using low-dose CT.

Methods: Five spherical solid artificial nodules [diameters 3, 5, 8, 10 and 12mm; CT density 1100 Hounsfield units (HU)] were randomly placed inside an anthropomorphic thoracic phantom in different combinations. The phantom was examined on two 64-row multidetector CT (64-MDCT) systems (CT-A and CT-B) from different vendors with a low-dose protocol. Each CT examination was performed three times. The CT examinations were evaluated twice by independent blinded observers. Nodule volume was semi-automatically measured by dedicated software. Interscanner variability was evaluated by Bland-Altman analysis and expressed as 95% confidence interval (CI) of relative differences. Intrascanner variability was expressed as 95% CI of relative variation from the mean.

Results: No significant difference in CT-derived volume was found between CT-A and CT-B, except for the 3-mm nodules (p= 8mm nodules, respectively. The 95% CI of intrascanner variability was within +/- 28.6%, +/- 13.4% and +/- 2.6% for 3, 5 and >= 8 mm nodules, respectively.

Conclusion: Different 64-MDCT scanners in low-dose settings yield good agreement in volumetry of artificial pulmonary nodules between 5mm and 12mm in diameter. Inter- and intrascanner variability decreases at a larger nodule size to a maximum of 4.9% for >= 8 mm nodules.

Advances in knowledge: The commonly accepted cut-off of 25% to determine nodule growth has the potential to be reduced for >= 8 mm nodules. This offers the possibility of reducing the interval for repeated CT scans in lung cancer screenings.

Original languageEnglish
Article number20130160
Number of pages9
JournalBritish journal of radiology
Volume86
Issue number1029
Publication statusPublished - Sep-2013

    Keywords

  • COMPUTER-AIDED VOLUMETRY, VIVO PORCINE LUNGS, AUTOMATED VOLUMETRY, MULTIDETECTOR CT, QUANTITATIVE CT, MULTISLICE CT, FOLLOW-UP, CANCER, ACCURACY, SIZE

ID: 5951802