Publication

Integrin-growth factor interactions,as regulators of oligodendroglial development and function

Baron, W., Colognato, H. & Ffrench-Constant, C., Mar-2005, In : Glia. 49, 4, p. 467-479 13 p.

Research output: Contribution to journalReview articleAcademicpeer-review

  • W Baron
  • H Colognato
  • C Ffrench-Constant

Central nervous system (CNS) development requires mechanisms for the regulation of cell number. Although growth factors are essential determinants of the proliferation and apoptosis that determine final numbers, the long-range nature of signals from diffusible growth factors makes them insufficient for the provision of the precise and localized signals required. Integration of integrin and growth factor receptor signaling in controlling cell behavior has been an important theme of research over the past several years. The focus of this review is on the mechanisms by which integrin-growth factor interactions regulate the development of oligodendrocytes and provide a mechanism for controlling, both in space and in time, oligodendrocyte numbers in the developing CNS. (C) 2004 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)467-479
Number of pages13
JournalGlia
Volume49
Issue number4
Publication statusPublished - Mar-2005

    Keywords

  • platelet-derived growth factor, neuregulin, extracellular matrix, lipid raft, integrin activation, apoptosis, proliferation, laminin, vitronectin, MULTIPLE-SCLEROSIS LESIONS, CENTRAL-NERVOUS-SYSTEM, SCHWANN-CELL PROLIFERATION, RAT-BRAIN OLIGODENDROCYTES, NEU DIFFERENTIATION FACTOR, ERBB RECEPTOR EXPRESSION, ADHESION MOLECULE L1, ALPHA-V INTEGRINS, EXTRACELLULAR-MATRIX, PROGENITOR CELLS

ID: 4301898