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Integrating molecular nuclear imaging in clinical research to improve anticancer therapy

de Vries, E. G. E., Kist de Ruijter, L., Lub-de Hooge, M. N., Dierckx, R. A., Elias, S. G. & Oosting, S. F., Apr-2019, In : Nature Reviews Clinical Oncology. 16, 4, p. 241-255 15 p.

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  • Integrating molecular nuclear imaging in clinical research to improve anticancer therapy

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DOI

Effective patient selection before or early during treatment is important to increasing the therapeutic benefits of anticancer treatments. This selection process is often predicated on biomarkers, predominantly biospecimen biomarkers derived from blood or tumour tissue; however, such biomarkers provide limited information about the true extent of disease or about the characteristics of different, potentially heterogeneous tumours present in an individual patient. Molecular imaging can also produce quantitative outputs; such imaging biomarkers can help to fill these knowledge gaps by providing complementary information on tumour characteristics, including heterogeneity and the microenvironment, as well as on pharmacokinetic parameters, drug- target engagement and responses to treatment. This integrative approach could therefore streamline biomarker and drug development, although a range of issues need to be overcome in order to enable a broader use of molecular imaging in clinical trials. In this Perspective article, we outline the multistage process of developing novel molecular imaging biomarkers. We discuss the challenges that have restricted the use of molecular imaging in clinical oncology research to date and outline future opportunities in this area.

Original languageEnglish
Pages (from-to)241-255
Number of pages15
JournalNature Reviews Clinical Oncology
Volume16
Issue number4
Early online date27-Nov-2018
Publication statusPublished - Apr-2019

    Keywords

  • POSITRON-EMISSION-TOMOGRAPHY, MACROPHAGE MANNOSE RECEPTOR, METASTATIC BREAST-CANCER, LOCALLY ADVANCED HEAD, NECK-CANCER, TUMOR HYPOXIA, F-18-FLUOROMISONIDAZOLE PET, IN-VIVO, COMPARATIVE BIODISTRIBUTION, ZR-89-BEVACIZUMAB PET

ID: 71885973