Publication

Insulin-like growth factor-I receptors in normal appearing white matter and chronic plaques in multiple sclerosis

Wilczak, N. & DeKeyser, J., 24-Oct-1997, In : Brain Research. 772, 1-2, p. 243-246 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Preclinical studies suggest that insulin-like growth factor-I (IGF-I) plays an important role in oligodendrocyte survival and myelination. We used human recombinant [I-125]IGF-I to study IGF-I receptors in post-mortem brain tissue from patients with multiple sclerosis (MS). In normal appearing white matter, we found that IGF-I receptor densities and binding characteristics were not different between MS patients and controls. In chronic plaques, histologically characterized by astrogliosis, we found densities of IGF-I receptors which were in the same range as those measured in the normal appearing white matter. In vitro studies have shown that IGF-I also acts as a mitogenic factor for astrocytes. Since MS lesions are rapidly invaded by reactive astrocytes, IGF-I may not only protect oligodendrocytes and stimulate remyelination but also enhance the astrogliosis that limits repair. (C) 1997 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)243-246
Number of pages4
JournalBrain Research
Volume772
Issue number1-2
Publication statusPublished - 24-Oct-1997

    Keywords

  • multiple sclerosis, insulin-like growth factor-I, insulin-like growth factor-I receptor, myelination, astrogliosis, CENTRAL-NERVOUS-SYSTEM, OLIGODENDROCYTE DEVELOPMENT, IGF-I, BRAIN, RAT, MYELINATION, ENCEPHALOMYELITIS, PROTEINS

ID: 6533980