Publication

Insm1 Induces Neural Progenitor Delamination in Developing Neocortex via Downregulation of the Adherens Junction Belt-Specific Protein Plekha7

Tavano, S., Taverna, E., Kalebic, N., Haffner, C., Namba, T., Dahl, A., Wilsch-Braeuninger, M., Paridaen, J. T. M. L. & Huttner, W. B., 21-Mar-2018, In : Neuron. 97, 6, p. 1299-1344 25 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Tavano, S., Taverna, E., Kalebic, N., Haffner, C., Namba, T., Dahl, A., ... Huttner, W. B. (2018). Insm1 Induces Neural Progenitor Delamination in Developing Neocortex via Downregulation of the Adherens Junction Belt-Specific Protein Plekha7. Neuron, 97(6), 1299-1344. https://doi.org/10.1016/j.neuron.2018.01.052

Author

Tavano, Stefania ; Taverna, Elena ; Kalebic, Nereo ; Haffner, Christiane ; Namba, Takashi ; Dahl, Andreas ; Wilsch-Braeuninger, Michaela ; Paridaen, Judith T. M. L. ; Huttner, Wieland B. / Insm1 Induces Neural Progenitor Delamination in Developing Neocortex via Downregulation of the Adherens Junction Belt-Specific Protein Plekha7. In: Neuron. 2018 ; Vol. 97, No. 6. pp. 1299-1344.

Harvard

Tavano, S, Taverna, E, Kalebic, N, Haffner, C, Namba, T, Dahl, A, Wilsch-Braeuninger, M, Paridaen, JTML & Huttner, WB 2018, 'Insm1 Induces Neural Progenitor Delamination in Developing Neocortex via Downregulation of the Adherens Junction Belt-Specific Protein Plekha7', Neuron, vol. 97, no. 6, pp. 1299-1344. https://doi.org/10.1016/j.neuron.2018.01.052

Standard

Insm1 Induces Neural Progenitor Delamination in Developing Neocortex via Downregulation of the Adherens Junction Belt-Specific Protein Plekha7. / Tavano, Stefania; Taverna, Elena; Kalebic, Nereo; Haffner, Christiane; Namba, Takashi; Dahl, Andreas; Wilsch-Braeuninger, Michaela; Paridaen, Judith T. M. L.; Huttner, Wieland B.

In: Neuron, Vol. 97, No. 6, 21.03.2018, p. 1299-1344.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Tavano S, Taverna E, Kalebic N, Haffner C, Namba T, Dahl A et al. Insm1 Induces Neural Progenitor Delamination in Developing Neocortex via Downregulation of the Adherens Junction Belt-Specific Protein Plekha7. Neuron. 2018 Mar 21;97(6):1299-1344. https://doi.org/10.1016/j.neuron.2018.01.052


BibTeX

@article{711d1c28f9124b10a3d4f92afe4c8156,
title = "Insm1 Induces Neural Progenitor Delamination in Developing Neocortex via Downregulation of the Adherens Junction Belt-Specific Protein Plekha7",
abstract = "Delamination of neural progenitor cells (NPCs) from the ventricular surface is a crucial prerequisite to form the subventricular zone, the germinal layer linked to the expansion of the mammalian neocortex in development and evolution. Here, we dissect the molecular mechanismby which the transcription factor Insm1 promotes the generation of basal progenitors (BPs). Insm1 protein is most highly expressed in newborn BPs in mouse and human developing neocortex. Forced Insm1 expression in embryonic mouse neocortex causes NPC delamination, converting apical to basal radial glia. Insm1 represses the expression of the apical adherens junction belt-specific protein Plekha7. CRISPR/Cas9-mediated disruption of Plekha7 expression suffices to cause NPC delamination. Plekha7 overexpression impedes the intrinsic and counteracts the Insm1-induced, NPC delamination. Our findings uncover a novel molecular mechanism underlying NPC delamination in which a BP-genic transcription factor specifically targets the integrity of the apical adherens junction belt, rather than adherens junction components as such.",
keywords = "PRIMARY CILIUM, CELL BIOLOGY, RADIAL GLIA, STEM-CELLS, EVOLUTION, NEUROGENESIS, EXPANSION, PROMOTES, AJUBA, MAINTENANCE",
author = "Stefania Tavano and Elena Taverna and Nereo Kalebic and Christiane Haffner and Takashi Namba and Andreas Dahl and Michaela Wilsch-Braeuninger and Paridaen, {Judith T. M. L.} and Huttner, {Wieland B.}",
year = "2018",
month = "3",
day = "21",
doi = "10.1016/j.neuron.2018.01.052",
language = "English",
volume = "97",
pages = "1299--1344",
journal = "Neuron",
issn = "0896-6273",
publisher = "CELL PRESS",
number = "6",

}

RIS

TY - JOUR

T1 - Insm1 Induces Neural Progenitor Delamination in Developing Neocortex via Downregulation of the Adherens Junction Belt-Specific Protein Plekha7

AU - Tavano, Stefania

AU - Taverna, Elena

AU - Kalebic, Nereo

AU - Haffner, Christiane

AU - Namba, Takashi

AU - Dahl, Andreas

AU - Wilsch-Braeuninger, Michaela

AU - Paridaen, Judith T. M. L.

AU - Huttner, Wieland B.

PY - 2018/3/21

Y1 - 2018/3/21

N2 - Delamination of neural progenitor cells (NPCs) from the ventricular surface is a crucial prerequisite to form the subventricular zone, the germinal layer linked to the expansion of the mammalian neocortex in development and evolution. Here, we dissect the molecular mechanismby which the transcription factor Insm1 promotes the generation of basal progenitors (BPs). Insm1 protein is most highly expressed in newborn BPs in mouse and human developing neocortex. Forced Insm1 expression in embryonic mouse neocortex causes NPC delamination, converting apical to basal radial glia. Insm1 represses the expression of the apical adherens junction belt-specific protein Plekha7. CRISPR/Cas9-mediated disruption of Plekha7 expression suffices to cause NPC delamination. Plekha7 overexpression impedes the intrinsic and counteracts the Insm1-induced, NPC delamination. Our findings uncover a novel molecular mechanism underlying NPC delamination in which a BP-genic transcription factor specifically targets the integrity of the apical adherens junction belt, rather than adherens junction components as such.

AB - Delamination of neural progenitor cells (NPCs) from the ventricular surface is a crucial prerequisite to form the subventricular zone, the germinal layer linked to the expansion of the mammalian neocortex in development and evolution. Here, we dissect the molecular mechanismby which the transcription factor Insm1 promotes the generation of basal progenitors (BPs). Insm1 protein is most highly expressed in newborn BPs in mouse and human developing neocortex. Forced Insm1 expression in embryonic mouse neocortex causes NPC delamination, converting apical to basal radial glia. Insm1 represses the expression of the apical adherens junction belt-specific protein Plekha7. CRISPR/Cas9-mediated disruption of Plekha7 expression suffices to cause NPC delamination. Plekha7 overexpression impedes the intrinsic and counteracts the Insm1-induced, NPC delamination. Our findings uncover a novel molecular mechanism underlying NPC delamination in which a BP-genic transcription factor specifically targets the integrity of the apical adherens junction belt, rather than adherens junction components as such.

KW - PRIMARY CILIUM

KW - CELL BIOLOGY

KW - RADIAL GLIA

KW - STEM-CELLS

KW - EVOLUTION

KW - NEUROGENESIS

KW - EXPANSION

KW - PROMOTES

KW - AJUBA

KW - MAINTENANCE

U2 - 10.1016/j.neuron.2018.01.052

DO - 10.1016/j.neuron.2018.01.052

M3 - Article

VL - 97

SP - 1299

EP - 1344

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 6

ER -

ID: 65099493