Publication

Inhibition of high-mobility group box 1 as therapeutic option in autoimmune disease: lessons from animal models

Schaper, F., Heeringa, P., Bijl, M. & Westra, J., Mar-2013, In : CURRENT OPINION IN RHEUMATOLOGY. 25, 2, p. 254-259 6 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Purpose of review

High-mobility group box 1 (HMGB1) is a molecule that has gained much attention in the last couple of years as an important player in innate immune responses and modulating factor in several (auto) immune diseases. Furthermore, advancements have been made in identifying the diverse functions that HMGB1 can play in the body by studying its receptors, pathways and effects. This review will focus on the modulation of HMGB1 in animal models of (auto) immune diseases.

Recent findings

In different disease models like sepsis, ischemia-reperfusion and arthritis, HMGB1-blocking therapies have been tested and the disease course was shown to be ameliorated.

Summary

These findings indicate that HMGB1 is an important mediator in innate immunity, inflammation and sterile injury. Furthermore, HMGB1 might be a new therapeutic target in inflammation and autoimmune diseases, which may be translated to the clinic.

Original languageEnglish
Pages (from-to)254-259
Number of pages6
JournalCURRENT OPINION IN RHEUMATOLOGY
Volume25
Issue number2
Publication statusPublished - Mar-2013

    Keywords

  • animal models, anti-HMGB1, autoimmune diseases, HMGB1, intervention, CHROMOSOMAL-PROTEIN 1, SYSTEMIC-LUPUS-ERYTHEMATOSUS, ISCHEMIA-REPERFUSION INJURY, RECEPTOR 4, HIGH-MOBILITY-GROUP-BOX-1 PROTEIN, HMGB1 TRANSLOCATION, INDUCED ARTHRITIS, CELL RECRUITMENT, CYTOKINE RELEASE, HUMAN MONOCYTES

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