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Influence of heart rate on coronary calcium scores: A multi-manufacturer phantom study

van der Werf, N. R., Willemink, M. J., Willems, T. P., Vliegenthart, R., Greuter, M. J. W. & Leiner, T., Jun-2018, In : International Journal Of Cardiovascular Imaging. 34, 6, p. 959-966 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

To evaluate the influence of heart rate on coronary calcium scores (CCS) using a dynamic phantom on four high-end computed tomography (CT) systems from different manufacturers. Artificial coronary arteries were moved in an anthropomorphic chest phantom at linear velocities, corresponding to < 60, 60-75 and > 75 beats per minute (bpm). Data was acquired with routinely used clinical protocols for CCS on four high-end CT systems (CT1-CT4). CCS, quantified as Agatston and mass scores were compared to reference scores at < 60 bpm. Influence of heart rate was assessed for each system with the cardiac motion susceptibility (CMS) Index. At increased heart rates (> 75 bpm), Agatston scores of the low mass calcification were similar to the reference score, while Agatston scores of the medium and high mass calcification increased significantly up to 50% for all CT systems. Threefold CMS increases at > 75 bpm in comparison with < 60 bpm were shown. For medium and high mass calcifications, significant differences in CMS between CT systems were found. Heart rate substantially influences CCS for high-end CT systems of four major manufacturers, but CT systems differ in motion susceptibility. Follow-up CCS CT scans should be acquired on the same CT system and protocol, and preferably with comparable heart rates.

Original languageEnglish
Pages (from-to)959-966
Number of pages8
JournalInternational Journal Of Cardiovascular Imaging
Volume34
Issue number6
Publication statusPublished - Jun-2018

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  • Journal Article

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