Publication

Influence of bariatric surgery on the use of medication

Yska, J. P., van der Meer, D. H., Dreijer, A. R., Eilander, W., Apers, J. A., Emous, M., Totte, E. R. E., Wilffert, B. & van Roon, E. N., Feb-2016, In : European Journal of Clinical Pharmacology. 72, 2, p. 203-209 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Yska, J. P., van der Meer, D. H., Dreijer, A. R., Eilander, W., Apers, J. A., Emous, M., ... van Roon, E. N. (2016). Influence of bariatric surgery on the use of medication. European Journal of Clinical Pharmacology, 72(2), 203-209. https://doi.org/10.1007/s00228-015-1971-3

Author

Yska, Jan Peter ; van der Meer, Douwe H. ; Dreijer, Albert R. ; Eilander, Willeke ; Apers, Jan A. ; Emous, Marloes ; Totte, Erik R. E. ; Wilffert, Bob ; van Roon, Eric N. / Influence of bariatric surgery on the use of medication. In: European Journal of Clinical Pharmacology. 2016 ; Vol. 72, No. 2. pp. 203-209.

Harvard

Yska, JP, van der Meer, DH, Dreijer, AR, Eilander, W, Apers, JA, Emous, M, Totte, ERE, Wilffert, B & van Roon, EN 2016, 'Influence of bariatric surgery on the use of medication', European Journal of Clinical Pharmacology, vol. 72, no. 2, pp. 203-209. https://doi.org/10.1007/s00228-015-1971-3

Standard

Influence of bariatric surgery on the use of medication. / Yska, Jan Peter; van der Meer, Douwe H.; Dreijer, Albert R.; Eilander, Willeke; Apers, Jan A.; Emous, Marloes; Totte, Erik R. E.; Wilffert, Bob; van Roon, Eric N.

In: European Journal of Clinical Pharmacology, Vol. 72, No. 2, 02.2016, p. 203-209.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Yska JP, van der Meer DH, Dreijer AR, Eilander W, Apers JA, Emous M et al. Influence of bariatric surgery on the use of medication. European Journal of Clinical Pharmacology. 2016 Feb;72(2):203-209. https://doi.org/10.1007/s00228-015-1971-3


BibTeX

@article{c5dfa3d13605429398e3a28799a87b86,
title = "Influence of bariatric surgery on the use of medication",
abstract = "PURPOSE: Bariatric surgery can influence the prevalence and incidence of comorbidities, as well as the pharmacokinetics of drugs. This might lead to changes in the use of drugs. This study aimed to assess the influence of bariatric surgery on the use of medication in patients before and after surgery, focusing on type, number of medications, and daily dosage.METHODS: In a retrospective and prospective observational study, drug dispensing data from pharmacies of patients undergoing their first bariatric surgery between January 2008 and September 2011 was collected. Dispensing data from 1 month before until 12 months after surgery was analyzed. Drugs were classified according to the WHO-ATC classification system. Dosages of drugs were compared using defined daily dose (DDD).RESULTS: Among 450 patients, 12 months after surgery, the mean number of drugs per patient for antidiabetics, drugs acting on the cardiovascular system, anti-inflammatory and antirheumatic drugs, and drugs for obstructed airway diseases decreased by, respectively, 71.3 {\%} (95 {\%} CI 57.2 to 85.4), 34.5 {\%} (95 {\%} CI 28.2 to 43.0), 45.5 {\%} (95 {\%} CI 13.3 to 72.6), and 33.1 {\%} (95 {\%} CI 15.3 to 53.2). Patients used lower median DDD of oral antidiabetics, beta-blocking agents, and lipid-modifying drugs.CONCLUSIONS: For some major drug classes 12 months after bariatric surgery, the use of drugs decreases in terms of mean number per patient. A reduction in dose intensity was observed for oral antidiabetics, beta-blocking agents, and lipid-modifying drugs. Dispensing data from pharmacies may provide detailed information on the use of medications by patients after bariatric surgery.",
keywords = "Bariatric surgery, Medication use, Dispensing data, Defined daily dose, GASTRIC BYPASS, OBESITY, GUIDELINES, PATIENT",
author = "Yska, {Jan Peter} and {van der Meer}, {Douwe H.} and Dreijer, {Albert R.} and Willeke Eilander and Apers, {Jan A.} and Marloes Emous and Totte, {Erik R. E.} and Bob Wilffert and {van Roon}, {Eric N.}",
year = "2016",
month = "2",
doi = "10.1007/s00228-015-1971-3",
language = "English",
volume = "72",
pages = "203--209",
journal = "European Journal of Clinical Pharmacology",
issn = "0031-6970",
publisher = "Springer Verlag",
number = "2",

}

RIS

TY - JOUR

T1 - Influence of bariatric surgery on the use of medication

AU - Yska, Jan Peter

AU - van der Meer, Douwe H.

AU - Dreijer, Albert R.

AU - Eilander, Willeke

AU - Apers, Jan A.

AU - Emous, Marloes

AU - Totte, Erik R. E.

AU - Wilffert, Bob

AU - van Roon, Eric N.

PY - 2016/2

Y1 - 2016/2

N2 - PURPOSE: Bariatric surgery can influence the prevalence and incidence of comorbidities, as well as the pharmacokinetics of drugs. This might lead to changes in the use of drugs. This study aimed to assess the influence of bariatric surgery on the use of medication in patients before and after surgery, focusing on type, number of medications, and daily dosage.METHODS: In a retrospective and prospective observational study, drug dispensing data from pharmacies of patients undergoing their first bariatric surgery between January 2008 and September 2011 was collected. Dispensing data from 1 month before until 12 months after surgery was analyzed. Drugs were classified according to the WHO-ATC classification system. Dosages of drugs were compared using defined daily dose (DDD).RESULTS: Among 450 patients, 12 months after surgery, the mean number of drugs per patient for antidiabetics, drugs acting on the cardiovascular system, anti-inflammatory and antirheumatic drugs, and drugs for obstructed airway diseases decreased by, respectively, 71.3 % (95 % CI 57.2 to 85.4), 34.5 % (95 % CI 28.2 to 43.0), 45.5 % (95 % CI 13.3 to 72.6), and 33.1 % (95 % CI 15.3 to 53.2). Patients used lower median DDD of oral antidiabetics, beta-blocking agents, and lipid-modifying drugs.CONCLUSIONS: For some major drug classes 12 months after bariatric surgery, the use of drugs decreases in terms of mean number per patient. A reduction in dose intensity was observed for oral antidiabetics, beta-blocking agents, and lipid-modifying drugs. Dispensing data from pharmacies may provide detailed information on the use of medications by patients after bariatric surgery.

AB - PURPOSE: Bariatric surgery can influence the prevalence and incidence of comorbidities, as well as the pharmacokinetics of drugs. This might lead to changes in the use of drugs. This study aimed to assess the influence of bariatric surgery on the use of medication in patients before and after surgery, focusing on type, number of medications, and daily dosage.METHODS: In a retrospective and prospective observational study, drug dispensing data from pharmacies of patients undergoing their first bariatric surgery between January 2008 and September 2011 was collected. Dispensing data from 1 month before until 12 months after surgery was analyzed. Drugs were classified according to the WHO-ATC classification system. Dosages of drugs were compared using defined daily dose (DDD).RESULTS: Among 450 patients, 12 months after surgery, the mean number of drugs per patient for antidiabetics, drugs acting on the cardiovascular system, anti-inflammatory and antirheumatic drugs, and drugs for obstructed airway diseases decreased by, respectively, 71.3 % (95 % CI 57.2 to 85.4), 34.5 % (95 % CI 28.2 to 43.0), 45.5 % (95 % CI 13.3 to 72.6), and 33.1 % (95 % CI 15.3 to 53.2). Patients used lower median DDD of oral antidiabetics, beta-blocking agents, and lipid-modifying drugs.CONCLUSIONS: For some major drug classes 12 months after bariatric surgery, the use of drugs decreases in terms of mean number per patient. A reduction in dose intensity was observed for oral antidiabetics, beta-blocking agents, and lipid-modifying drugs. Dispensing data from pharmacies may provide detailed information on the use of medications by patients after bariatric surgery.

KW - Bariatric surgery

KW - Medication use

KW - Dispensing data

KW - Defined daily dose

KW - GASTRIC BYPASS

KW - OBESITY

KW - GUIDELINES

KW - PATIENT

U2 - 10.1007/s00228-015-1971-3

DO - 10.1007/s00228-015-1971-3

M3 - Article

VL - 72

SP - 203

EP - 209

JO - European Journal of Clinical Pharmacology

JF - European Journal of Clinical Pharmacology

SN - 0031-6970

IS - 2

ER -

ID: 25751843