INFLUENCE OF AGING ON ANTIBODY-FORMATION INVIVO AFTER IMMUNIZATION WITH THE PRIMARY T-CELL DEPENDENT ANTIGEN HELIX-POMATIA HEMOCYANINDEGREEF, GE., KALLENBERG, CGM., VANSTAALDUINEN, GJ., REMARQUE, EJ., TJANDRA, YI. & HIJMANS, W., Oct-1992, In : Mechanisms of Ageing and Development. 66, 1, p. 15 - 28 14 p.
Research output: Contribution to journal › Article › Academic › peer-review
The in vivo antibody response to the primary T-cell dependent antigen Helix pomatia Haemocyanin (HPH) was studied, in order to detect the possible presence of a humoral immune deficiency in ageing. The IgG subclass distribution of the specific antibodies was also determined. In order to define a dose of HPH which could be used to discriminate between the responsiveness of healthy and immunocompromised individuals, we first established a dose-response curve for this antigen in 60 healthy young volunteers. Their responses were compared with the responses of a group of patients suffering from end stage renal failure. The patients who were treated with haemodialysis showed a significantly lower IgM, IgG and IgA anti-HPH antibody response after immunisation with a dose of 30 mug HPH, which could be restored by increasing the antigen dose. Patients treated with continuous ambulant peritoneal dialysis and a group of elderly persons, selected according to the Senieur protocol, showed no impairment of antibody formation after immunisation with 30 mug HPH, but in the non-Senieur elderly the anti-HPH antibody response was significantly lower. Furthermore, Senieur and non-Senieur elderly persons showed a diminished IgG2 anti-HPH antibody formation, whereas in the elderly non-Senieur individuals and in the patients with renal insufficiency, IgG1 and IgG3 anti-HPH antibodies were also diminished. This study clearly shows that the so-called age-associated immune deficiency can be the result of disease and is not necessarily due to the ageing process itself.
|Pages (from-to)||15 - 28|
|Number of pages||14|
|Journal||Mechanisms of Ageing and Development|
|Publication status||Published - Oct-1992|
- AGING, SENIEUR, HELIX-POMATIA HEMOCYANIN, ANTIBODIES, CAPD, HEMODIALYSIS, HEPATITIS-B VACCINE, KEYHOLE LIMPET HEMOCYANIN, IMMUNE-RESPONSE, IGG SUBCLASSES, HEMODIALYSIS-PATIENTS, IMMUNIZATION, INVITRO, SERUM, GLOMERULONEPHRITIS, IMMUNOGENICITY